Minor alkaloid from Coscinium fenestratum

Malhotra, Sanjay V.; Taneja, Subhash C.; Dhar, K.L.

doi:10.1016/s0031-9422(00)97910-x

Cited by 28 publications

(28 citation statements)

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“…Specifically, C. fenestratum is a widely used medicinal plant in Southeast asia (27). the major constituents of the stem are protoberberine alkaloids such as berberine, palmatine and jatrorrhizine (26,(28)(29)(30). in folkloric medicine, people favor the use of the stems and roots of C. fenestratum rather than the leaves due to their greater alkaloid content.…”

Section: Discussionmentioning

confidence: 99%

In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells

Rojsanga

Sukhthankar²,

Krisanapun³

et al. 2010

Experimental and Therapeutic Medicine

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Abstract. Coscinium fenestratum (Gaertn.) colebr. is traditionally used for the treatment of cancer, arthritis and diabetes mellitus. the purpose of this study was to determine the molecular mechanisms by which this plant shows beneficial effects. an 80% ethanolic extract of C. fenestratum (80et) was separated by its polarity into dichloromethane (dcm) and aqueous fractions (WF), and the anti-proliferative effects of 80et, dcm and WF were investigated. Berberine, one of the major components of C. fenestratum, was used as a control. the 80et, dcm, WF and berberine showed anti-proliferative activity as assessed by cell growth assay. Subsequently, the pro-apoptotic proteins naG-1 and atF3 were increased and the cell cycle protein cyclin d1 was decreased by the extract and its fractions. interestingly, only the dcm fraction exhibited the induction of peroxisome proliferator-activated receptor γ (pparγ) binding activity, which represents a pro-apoptotic activity in colorectal cancer cells. the overall results of this study indicate that the extract from this plant has anti-proliferative activity through the activation of pro-apoptotic proteins and pparγ, and may have potential as a preventive regimen in the treatment of cancer.

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Section: Discussionmentioning

confidence: 99%

In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells

Rojsanga

Sukhthankar²,

Krisanapun³

et al. 2010

Experimental and Therapeutic Medicine

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show abstract

“…The stem yields a yellow dye, which is used either alone or in combination with turmeric and other colouring materials (The Wealth of India, 1950). The roots of Coscinium fenestratum contain alkaloids berlambine, dihydroberlambine, 12, 13-dihydro-8-oxo berberine, tetrahydroberberine, oxyberberine and noroxy hydrastinine (Datta et al, 1988;Malhotra et al, 1989).…”

Section: Introductionmentioning

confidence: 99%

Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats

Shirwaikar

Rajendran

Punitha

2005

Journal of Ethnopharmacology

124

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“…Typical HPLC chromatograms of the extracts are shown in Figs. [3][4][5]. The identification of BE was based on comparison of retention times and UV spectra of peak of BE standard with the corresponding peak in the sample chromatogram.…”

Section: Hplc Analysismentioning

confidence: 99%

“…In the Siddha system of medicine, the powdered stem is dissolved in milk and given to the diabetic patients [3]. The rural people of Kanyakumarl District, Tamilnadu, India, use the decoction of the stem for treatment of diabetes [4]. Berberine (BE), a natural isoquinoline alkaloid, has been reported as the major bioactive chemical component of C. fenestratum [3,4].…”

Section: Introductionmentioning

confidence: 99%

“…The rural people of Kanyakumarl District, Tamilnadu, India, use the decoction of the stem for treatment of diabetes [4]. Berberine (BE), a natural isoquinoline alkaloid, has been reported as the major bioactive chemical component of C. fenestratum [3,4]. BE was found to be present in both vegetative and reproductive parts, indicating the secretion of berberine in all parts of the C. fenestratum plant [5].…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of HPLC and spectrophotometric methods for analysis of bioactive constituent berberine in stem extracts ofCoscinium fenestratum

Akowuah¹,

Okechukwu²,

Chiam³

2014

Acta Chromatographica

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Summary. High-performance liquid chromatography (HPLC) and ultraviolet (UV) spectrophotometric methods were developed for analysis of berberine, the principal bioactive constituent, in Coscinium fenestratum extracts. The HPLC and UV spectrophotometric determinations were performed at 226, 270, and 340 nm. The methods were validated by assessing linearity, sensitivity, precision, and accuracy. HPLC detection was found to be more effective than spectrophotometric determinations. The content of berberine determined by HPLC method at detection wavelengths of 270 and 340 nm was found to be higher as compared to the value obtained at wavelength of 226 nm. The content of berberine determined by HPLC ranged from 0.98 to 0.99 (%w/w) in the methanol extract, 0.85 to 0.88 (%w/w) in the methanol-water (1:1) extract, and 0.24 to 0.25 in the water extract.

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Minor alkaloid from Coscinium fenestratum

Cited by 28 publications

References 5 publications

In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells

In vitro anti-proliferative activity of alcoholic stem extract of Coscinium fenestratum in human colorectal cancer cells

Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide induced type 2 diabetic rats

Evaluation of HPLC and spectrophotometric methods for analysis of bioactive constituent berberine in stem extracts ofCoscinium fenestratum

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