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The methanol extract of the leaves of Gynura procumbens was partitioned between chloroform, ethyl acetate and nbutanol. Qualitative HPLC identification of the major flavonoid constituents in the n-butanol fraction and separation of standard mixture of isolated compounds from the n-butanol fraction are given. Blood glucose levels in streptozotocin-induced type 2 diabetic rats were reduced by the administration of 1 g/kg of the n-butanol fraction. The results were compared with glibenclamide used as standard drug. The fraction produced no significant effect in normal rats. Materials and methods Materials for hypoglycaemic studiesOven-dried powdered of the plant leaf, Male Sprague Dawley rats (190-250 g), streptozotocin (Sigma), distilled water, saline (0.9%), glibenclamide, YSI 2357 buffer concentrate, YSI 1531 standard D-glucose 900 mg/dl (CAS 50997) were obtained from commercial sources. ApparatusMelting points were determining on an electrothermal apparatus and are uncorrected. UV spectra were recorded on a Shimadzu UV-2000 ultraviolet spectrophotometer. Infrared spectra were recorded by IR Shimadzu 420 spectrophoto-

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