Minocycline attenuates depressive-like behaviors in mice treated with the low dose of intracerebroventricular streptozotocin; the role of mitochondrial function and neuroinflammation

Mozafari, Haniyeh; Amiri, Shayan; Mehr, Shahram Ejtemaei; Momeny, Majid; Amini-Khoei, Hossein; Bijani, Soroush; Hosseini, Mir-Jamal

doi:10.1007/s11033-020-05696-w

Cited by 16 publications

(8 citation statements)

References 36 publications

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“…Due to the rich lipid contents in the membrane of brain cells, excessive ROS destroys the structure and function of the phospholipid bilayer of brain cells through lipid peroxide, alters the permeability of the BBB, and ultimately exacerbates neuroinflammation [ 71 ]. Therefore, antidepressant effects could theoretically be exerted by reducing OS and neuroinflammatory responses; this is in agreement with the reports of the study by Nouri et al [ 79 ] and Mozafari et al [ 73 ].…”

Section: Relationship Between Inflammation and Depressionsupporting

confidence: 92%

“…Cerebral neuroinflammation, in addition to being associated with peripheral immunity, is also related to oxidative stress (OS) [ 70 , 71 ], mitochondrial dysfunction [ 72 , 73 ], energy metabolism disorders, nitroenergy system [ 74 , 75 ], eating habits [ 76 , 77 ], sleep quality [ 78 ], etc., to some extent.…”

Section: Relationship Between Inflammation and Depressionmentioning

confidence: 99%

“…Similarly, triggering OS leads to mitochondrial dysfunction as well as deficiency in cell energy, which further aggravates mitochondrial damage, forming a vicious circle [ 72 ]. The resulting multiple DAMP, such as ROS and lipid oxide, can activate inflammatory signals by activating TLRs and different mechanisms, such as inflammasome formation, which can also change the permeability of the BBB and eventually exacerbate neuroinflammation [ 73 ].…”

Section: Relationship Between Inflammation and Depressionmentioning

confidence: 99%

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α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Liu

Zhang

Shi

et al. 2023

J Neuroinflammation

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Depression is a common mental illness, which is related to monoamine neurotransmitters and the dysfunction of the cholinergic, immune, glutamatergic, and neuroendocrine systems. The hypothesis of monoamine neurotransmitters is one of the commonly recognized pathogenic mechanisms of depression; however, the drugs designed based on this hypothesis have not achieved good clinical results. A recent study demonstrated that depression and inflammation were strongly correlated, and the activation of alpha7 nicotinic acetylcholine receptor (α7 nAChR)-mediated cholinergic anti-inflammatory pathway (CAP) in the cholinergic system exhibited good therapeutic effects against depression. Therefore, anti-inflammation might be a potential direction for the treatment of depression. Moreover, it is also necessary to further reveal the key role of inflammation and α7 nAChR in the pathogenesis of depression. This review focused on the correlations between inflammation and depression as well-discussed the crucial role of α7 nAChR in the CAP.

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Section: Relationship Between Inflammation and Depressionsupporting

confidence: 92%

Section: Relationship Between Inflammation and Depressionmentioning

confidence: 99%

Section: Relationship Between Inflammation and Depressionmentioning

confidence: 99%

See 1 more Smart Citation

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Liu

Zhang

Shi

et al. 2023

J Neuroinflammation

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“…It seems that an increase in ROS levels subsequently leads to oxidative damage and pathogenesis of transient cerebral ischemia or stroke. The elevation in ROS production stimulated interaction with macromolecules and activation of cell death signaling pathways [ 21 , 37 ].…”

Section: Discussionmentioning

confidence: 99%

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Mozafari

Rashidzadeh

Bijani

et al. 2023

Oxidative Medicine and Cellular Longevity

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Ischemic stroke is the most common among various stroke types and the second leading cause of death, worldwide. Edaravone (EDV) is one of the cardinal antioxidants that is capable of scavenging reactive oxygen species, especially hydroxyl molecules, and has been already used for ischemic stroke treatment. However, poor water solubility, low stability, and bioavailability in aqueous media are major EDV drawbacks. Thus, to overcome the aforementioned drawbacks, nanogel was exploited as a drug carrier of EDV. Furthermore, decorating the nanogel surface with glutathione as targeting ligands would potentiate the therapeutic efficacy. Nanovehicle characterization was assessed with various analytical techniques. Size (199 nm, hydrodynamic diameter) and zeta potential (-25 mV) of optimum formulation were assessed. The outcome demonstrated a diameter of around 100 nm, sphere shape, and homogenous morphology. Encapsulation efficiency and drug loading were determined to be 99.9% and 37.5%, respectively. In vitro drug release profile depicted a sustained release process. EDV and glutathione presence in one vehicle simultaneously made the possibility of antioxidant effects on the brain in specific doses, which resulted in elevated spatial memory and learning along with cognitive function in Wistar rats. In addition, significantly lower MDA and PCO and higher levels of neural GSH and antioxidant levels were observed, while histopathological improvement was approved. The developed nanogel can be a suited vehicle for drug delivery of EDV to the brain and improve ischemia-induced oxidative stress cell damage.

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“…Hyperactivated microglia secrete excessive pro‐inflammatory mediators, including tumor necrosis factor‐alpha (TNF‐α), interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and reactive oxygen species (ROS) (Cherry et al, 2014), which are toxic for neurons. In addition, the transcription level of inducible nitric oxide synthase (iNOS) increases in activated microglia, resulting in the excessive synthesis of downstream nitric oxide (NO), which can induce neuronal death (Anjomshoa et al, 2020; Haj‐Mirzaian et al, 2019; Hassanipour et al, 2016; Lorigooini et al, 2021; Mozafari et al, 2020). The hyperactivation and dysregulation of microglia contribute heavily to cognitive dysfunction in AD (Calsolaro & Edison, 2016).…”

Section: Introductionmentioning

confidence: 99%

Isoamericanin A improves lipopolysaccharide‐induced memory impairment in mice through suppression of the nicotinamide adenine dinucleotide phosphateoxidase‐dependent nuclear factor kappa B signaling pathway

Yang

Chen

Che

et al. 2023

Phytotherapy Research

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Alzheimer's disease (AD) is the most frequent cause of dementia in the elderly. Isoamericanin A (ISOA) is a natural lignan possessing great potential for AD treatment. This study investigated the efficacy of ISOA on memory impairments in the mice intrahippocampal injected with lipopolysaccharide (LPS) and the underlying mechanism. Y‐maze and Morris Water Maze data suggested that ISOA (5 and 10 mg/kg) ameliorated short‐ and long‐term memory impairments, and attenuated neuronal loss and lactate dehydrogenase activity. ISOA exerted anti‐inflammatory effect demonstrating by the reduction of ionized calcium‐binding adapter molecule 1 positive cells and suppression of marker protein and pro‐inflammation cytokines expressions induced by LPS. ISOA suppressed the nuclear factor kappa B (NF‐κB) signaling pathway by inhibiting IκBα phosphorylation and NF‐κB p65 phosphorylation and nuclear translocation. ISOA inhibited superoxide and intracellular reactive oxygen species accumulation by reducing nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activation, demonstrating by suppressing NADP+ and NADPH contents, gp91phox expression, and p47phox expression and membrane translocation. These effects were enhanced in combination with NADPH oxidase inhibitor apocynin. The neuroprotective effect of ISOA was further proved in the in vitro models. Overall, our data revealed a novel pharmacological activity of ISOA: ameliorating memory impairment in AD via inhibiting neuroinflammation.

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Minocycline attenuates depressive-like behaviors in mice treated with the low dose of intracerebroventricular streptozotocin; the role of mitochondrial function and neuroinflammation

Cited by 16 publications

References 36 publications

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect

Enhancing the Neuroprotection Potential of Edaravone in Transient Global Ischemia Treatment with Glutathione- (GSH-) Conjugated Poly(methacrylic acid) Nanogel as a Promising Carrier for Targeted Brain Drug Delivery

Isoamericanin A improves lipopolysaccharide‐induced memory impairment in mice through suppression of the nicotinamide adenine dinucleotide phosphateoxidase‐dependent nuclear factor kappa B signaling pathway

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