Minimalism in fabrication of self-organized nanogels holding both anti-cancer drug and targeting moiety

Potential of self-organizing nanogel with acetylated chondroitin sulfate as an anti-cancer drug carrier

“…The drug loading efficiency of AC-CS3 nanogels was above 90% (Table 1). This is indicative of high-level efficiency compared with other polysaccharide-based nanogels [9,10] and may be induced by involving another interaction between AC-CS and DOX, besides hydrophobic interaction. AC-CS3 nanogels harbor a number of anionic groups, including carboxyl and sulfate groups.…”

“…At a high shear rate, the nanogels may become elongated, further reducing the apparent viscosity of the blood. Our group reported some findings regarding self-organizing nanogels consisting of a polysaccharide conjugated to a hydrophobic moiety [8,10,11]. However, despite their clear potential, polysaccharides have not been generally employed at a frequency comparable to synthetic polymers because they are difficult to modify and analyze, due to solvent issues.…”

Self-assembling polymer systems for advanced treatment of cancer and inflammation

“…Some polysaccharides such as pullulans [72,74,75] or heparins [76,77] can be readily dissolved in organic solvents upon mild heating. For the solubilisation of other polysaccharides in organic solvents, inventive strategies have been designed.…”

Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide–doxorubicin conjugate loaded doxorubicin

“…Self-organized nanoparticles of modified polysaccharide amphiphiles have been intensively investigated in the biomedical and pharmaceutical fields due to their potential based on biocompatibility and abundance [4,13,15,16]. It is well known that nanoparticles consist of hydrophobic core and hydrophilic shell to make zero Gibb's energy and are able to enclose a hydrophobic drug in core and to protect interactions with biological environment.…”