Self-assembling polymer systems for advanced treatment of cancer and inflammation

Palao-Suay, Raquel; Gómez‐Mascaraque, Laura G.; Aguilar, María Rosa; Vázquez, Blanca; Román, Julio San

doi:10.1016/j.progpolymsci.2015.07.005

Cited by 44 publications

(19 citation statements)

References 339 publications

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“…Since HA is highly soluble in aqueous solutions, different methods have been used for its stabilization. Physical and chemical crosslinking or hydrophobization by hydrophobic moieties are among the favorites . For example, esterification of HA with fatty acid residues could be applied to prepare water‐insoluble fibers .…”

Section: Introductionmentioning

confidence: 99%

Optimization of cell growth on palmitoyl‐hyaluronan knitted scaffolds developed for tissue engineering applications

Sogorkova

Zapotocky

Čepa

et al. 2018

J Biomedical Materials Res

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Polysaccharides meet several criteria for a suitable biomaterial for tissue engineering, which include biocompatibility and ability to support the delivery and growth of cells. Nevertheless, most of these polysaccharides, for example dextran, alginate, and glycosaminoglycans, are highly soluble in aqueous solutions. Hyaluronic acid hydrophobized by palmitic acid and processed to the form of wet-spun fibers and the warp-knitted textile scaffold is water non-soluble, but biodegradable material, which could be used for the tissue engineering purpose. However, its surface quality does not allow cell attachment. To enhance the biocompatibility the surface of palmitoyl-hyaluronan was roughened by freeze drying and treated by different cell adhesive proteins (fibronectin, fibrinogen, laminin, methacrylated gelatin and collagen IV). Except for collagen IV, these proteins covered the fibers uniformly for an extended period of time and supported the adhesion and cultivation of dermal fibroblasts and mesenchymal stem cells. Interestingly, adipose stem cells cultivated on the fibronectin-modified scaffold secreted increasing amount of HGF, SDF-1, and VEGF, three key growth factors involved in cardiac regeneration. These results suggested that palmitoyl-hyaluronan scaffold may be a promising material for various applications in tissue regeneration, including cardiac tissue repair. © 2018 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 106A: 1488-1499, 2018.

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Section: Introductionmentioning

confidence: 99%

Optimization of cell growth on palmitoyl‐hyaluronan knitted scaffolds developed for tissue engineering applications

Sogorkova

Zapotocky

Čepa

et al. 2018

J Biomedical Materials Res

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“…If the drug is hydrophobic and forms part of a hydrophobic block, it will be concentrated in the core of the nanoparticles when suspended in water, and the disaggregation of the organized macromolecules will be necessary to expose or release the active principle and exert its action . The hydrophobic interactions between hydrophobic blocks lead to the chain organization in polymeric particles, and the hydrophilic repulsion contribute to the stabilization of the particles and to facilitate water diffusion to the interior of the NPs, that may play a critical role in chain disaggregation resulting hydrolysis of cleavable linkers and drug delivery …”

Section: Introductionmentioning

confidence: 99%

“…There are numerous reports in the literature describing the synthesis and characterization of amphiphilic polymeric nanocarriers for the treatment of cancer . However, there are not so many examples describing how the structure modification of one segment affects the bioactivity of the particle.…”

Section: Introductionmentioning

confidence: 99%

“…[10] The hydrophobic interactions between hydrophobic blocks lead to the chain organization in polymeric particles, and the hydrophilic repulsion contribute to the stabilization of the particles and to facilitate water diffusion to the interior of the NPs, that may play a critical role in chain disaggregation resulting hydrolysis of cleavable linkers and drug delivery. [11,12] There are numerous reports in the literature describing the synthesis and characterization of amphiphilic polymeric nanocarriers for the treatment of cancer. [12][13][14] However, there are not so many examples describing how the structure modification of one segment affects the bioactivity of the particle.…”

Section: Introductionmentioning

confidence: 99%

“…[11,12] There are numerous reports in the literature describing the synthesis and characterization of amphiphilic polymeric nanocarriers for the treatment of cancer. [12][13][14] However, there are not so many examples describing how the structure modification of one segment affects the bioactivity of the particle. In this sense, Zhang et al prepared NPs of poly(styrene-b-ethylene-co-butylene-b-styrene) by microphase inversion and studied the effect of different concentrations of carboxylic groups in the styrene residues.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Enhanced Bioactivity of α‐Tocopheryl Succinate Based Block Copolymer Nanoparticles by Reduced Hydrophobicity

Palao-Suay

Aguilar

Parra-Ruiz

et al. 2016

Macromolecular Bioscience

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Well-structured amphiphilic copolymers are necessary to obtain self-assembled nanoparticles (NPs) based on synthetic polymers. Highly homogeneous and monodispersed macromolecules obtained by controlled polymerization have successfully been used for this purpose. However, disaggregation of the organized macromolecules is desired when a bioactive element, such as α-tocopheryl succinate, is introduced in self-assembled NPs and this element must be exposed or released to exert its action. The aim of this work is to demonstrate that the bioactivity of synthetic NPs based on defined reversible addition-fragmentation chain transfer polymerization copolymers can be enhanced by the introduction of hydrophilic comonomers in the hydrophobic segment. The amphiphilic terpolymers are based on poly(ethylene glycol) (PEG) as hydrophilic block, and a hydrophobic block based on a methacrylic derivative of α-tocopheryl succinate (MTOS) and small amounts of 2-hydroxyethyl methacrylate (HEMA) (PEG-b-poly(MTOS-co-HEMA)). The introduction of HEMA reduces hydrophobicity and introduces “disorder” both in the homogeneous blocks and the compact core of the corresponding NPs. These NPs are able to encapsulate additional α-tocopheryl succinate (α-TOS) with high Efficiency and their biological activity is much higher than that described for the unmodified copolymers, proposedly due to more efficient degradation and release of α-TOS, demonstrating the importance of the hydrophilic–hydrophobic balance.

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γ‐Butyrolactone Copolymerization with the Well‐Documented Polymer Drug Carrier Poly(ethylene oxide)‐block‐poly(ε‐caprolactone) to Fine‐Tune Its Biorelevant Properties

Urbánek

Trousil

Rak

et al. 2020

Macromolecular Bioscience

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Polymeric drug carriers exhibit excellent properties that advance drug delivery systems. In particular, carriers based on poly(ethylene oxide)‐block‐poly(ε‐caprolactone) are very useful in pharmacokinetics. In addition to their proven biocompatibility, there are several requirements for the efficacy of the polymeric drug carriers after internalization, e.g., nanoparticle behavior, cellular uptake, the rate of degradation, and cellular localization. The introduction of γ‐butyrolactone units into the hydrophobic block enables the tuning of the abovementioned properties over a wide range. In this study, a relatively high content of γ‐butyrolactone units with a reasonable yield of ≈60% is achieved by anionic ring‐opening copolymerization using 1,5,7‐triazabicyclo[4.4.0]dec‐5‐ene as a very efficient catalyst in the nonpolar environment of toluene with an incorporated γ‐butyrolactone content of ≈30%. The content of γ‐butyrolactone units can be easily modulated according to the feed ratio of the monomers. This method enables control over the rate of degradation so that when the content of γ‐butyrolactone increases, the rate of degradation increases. These findings broaden the application possibilities of polyester‐polyether‐based nanoparticles for biomedical applications, such as drug delivery systems.

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Self-assembling polymer systems for advanced treatment of cancer and inflammation

Cited by 44 publications

References 339 publications

Optimization of cell growth on palmitoyl‐hyaluronan knitted scaffolds developed for tissue engineering applications

Optimization of cell growth on palmitoyl‐hyaluronan knitted scaffolds developed for tissue engineering applications

Enhanced Bioactivity of α‐Tocopheryl Succinate Based Block Copolymer Nanoparticles by Reduced Hydrophobicity

γ‐Butyrolactone Copolymerization with the Well‐Documented Polymer Drug Carrier Poly(ethylene oxide)‐block‐poly(ε‐caprolactone) to Fine‐Tune Its Biorelevant Properties

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