Self-assembled nanoparticle drug delivery systems from galactosylated polysaccharide–doxorubicin conjugate loaded doxorubicin

Cao, Yu; Gu, Ying; Ma, Hong; Bai, Jing; Liu, Lina; Zhao, Peiguang; He, Hongxuan

doi:10.1016/j.ijbiomac.2009.11.008

Cited by 63 publications

(29 citation statements)

References 18 publications

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“…267 XGC can be conjugated with DOX and galactosamine to form XGC-DOX-Galac NGs (142 nm), which show higher toxicity to HepG2 cells (a human liver cancer cell line) than to HeLa cells, suggesting their hepatocyte specificity in tumor therapy. 259 3.8.4. Curdlan-Based NGs.…”

Section: Other Natural Polymer-based Ngsmentioning

confidence: 99%

Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery

et al. 2015

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Section: Other Natural Polymer-based Ngsmentioning

confidence: 99%

Biodegradable Polymer Nanogels for Drug/Nucleic Acid Delivery

et al. 2015

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“…17 About 2 g xyloglucan powders were dissolved in 198 mL distilled water with intense stirring at 60 C. Then the solution was centrifuged (AVANTI J-26XP, BECKMANCOULTER, USA) with 10,000 rpm for 10 min to remove the water-insoluble fraction. The supernatant was filtrated with 1 mm membrane.…”

Section: Methodsmentioning

confidence: 99%

“…The enzyme-degraded xyloglucan is of great potentials used as drug-delivery carriers. [15][16][17] Our previous study showed that the dispersion effects of either xyloglucan or enzyme-degraded xyloglucan directly influenced their ability to release drugs. 16 In the present research, we first hypothesized that ultrasonic time may have significant influence on dispersion effects and then specifically studied the changes of particle size at different times.…”

Section: Introductionmentioning

confidence: 99%

Effects of ultrasonic dispersion in dilute polysaccharide solution

Chen

Liu

Chen

et al. 2014

J of Applied Polymer Sci

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In order to evaluate the relationship between dispersion and ultrasonic time, dynamic light scattering experiment was carried out on both 0.20 g/L xyloglucan solution and 0.20 g/L b-galactosidase-degraded xyloglucan solution with different time intervals. Data showed that the variation trends of particle size in xyloglucan and enzyme-degraded xyloglucan solution were similar: decreased first and then increased with the incremental time. Thus, there should be an optimum time interval during which the smallest particle size can be obtained if experimental conditions were excluded in theoretically. In addition, the optimum time interval varies in different polysaccharides since it may be associated with molecular conformation, based on the results of our work. V C 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014, 131, 40973.

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“…For example, polybutylvyanoacrylate NPs was loaded with rifampicin and it showed antibacterial activity against S. aureus and Mycobacterium avium due to effective delivery of the drugs to macrophages both in vitro and in vivo. Cao et al (2010) used, xyloglucan (polymer) was grafted with doxorubicin (DOX) and galactosamine and was used to target liver hepatocytes. This novel nano DDS showed improved transfection efficiency and hepatocyte specificity, which could be useful for tumor therapy.…”

Section: Solid Lipid Nanoparticles (Sln) As Drug Delivery Carriermentioning

confidence: 99%