Minimal immunoreactive plasma β-endorphin and decrease of cortisol at standard analgesia or different acupuncture techniques

Harbach, Heinz W.; Moll, Bettina; Boedeker, Rolf-Hasso; Vigelius-Rauch, Ursula; Otto, H. H.; Muehling, Joerg; Hempelmann, G.; Markart, Philipp

doi:10.1017/s0265021506001906

Cited by 30 publications

(14 citation statements)

References 26 publications

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“…Several previous studies, however, have indicated that opioid antagonists have failed to interfere with acupuncture analgesia under certain circumstances (McLennan et al, 1977;Bossut et al, 1991;Chapman et al, 1980Chapman et al, , 1983Takeshige et al, 1980Takeshige et al, , 1992Koo et al, 2002). In fact, a recent study (Harbach et al, 2006) concluded that beta-endorphin is released by stress but not by the acupuncture procedure per se during acupuncture treatment. On the other hand, there is evidence suggesting that nonopioid systems may be involved in EA-induced analgesia.…”

Section: Discussionmentioning

confidence: 98%

Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal α-adrenoceptors

Koo

Lim

Chung

et al. 2008

Pain

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In a previous study, we showed that electroacupuncture (EA) applied to the SI-6 point on the contralateral forelimb produces long-lasting and powerful analgesia in pain caused by ankle sprain in a rat model. To investigate the underlying mechanism of EA analgesia, the present study tested the effects of various antagonists to known endogenous analgesic systems in this model. Ankle sprain was induced in anesthetized rats by overextending their right ankle with repeated forceful plantar flexion and inversion of the foot. When rats developed pain behaviors (a reduction in weight bearing of the affected hind limb), EA was applied to the SI-6 point on the contralateral forelimb for 30 minutes under halothane anesthesia. EA significantly improved the weight-bearing capacity of the affected hind limb for 2 hours, suggesting an analgesic effect. The alpha-adrenoceptor antagonist phentolamine (2 mg/kg, i.p. or 30 μg, i.t.) completely blocked the EA-induced analgesia, whereas naloxone (1 mg/kg, i.p.) and failed to block the effect. These results suggest that EA-induced analgesia is mediated by alpha-adrenoceptor mechanisms. Further experiments showed that intrathecal administration of yohimbine (10 μg), an α 2 -adrenergic antagonist, reduced the EAinduced analgesia in a dose-dependent manner, whereas terazosin (10 μg), an α 1 -adrenergic antagonist, did not produce any effect. These data suggest that the analgesic effect of EA in ankle sprain pain is, at least in part, mediated by spinal α 2 -adrenoceptor mechanisms.

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Section: Discussionmentioning

confidence: 98%

Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal α-adrenoceptors

Koo

Lim

Chung

et al. 2008

Pain

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“…The eCB system works through Rho and Rac (e.g. Berghuis et al, 2007;He and Song, 2007), and acupuncture may work through the eCB system (Li et al, 2007), rather than the endorphin system as assumed previously (Harbach et al, 2007). Similarly, the eCB system may be responsible for ''runner's high''-running on a treadmill raises serum AEA levels (Sparling et al, 2003;Dietrich et al, 2004).…”

Section: Clinical Discussionmentioning

confidence: 98%

Expression of the endocannabinoid system in fibroblasts and myofascial tissues

McPartland

2008

Journal of Bodywork and Movement Therapies

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“…[12] However, serum COR levels were reported to decrease by 40.8% during electric acupuncture at nonacupuncture points in patients with chronic low back pain. [13] However, to our knowledge, there are no published reports relevant to local heating agents.…”

Section: Discussionmentioning

confidence: 99%

The effects of physical therapeutic agents on serum levels of stress hormones in patients with osteoarthritis

Tönük

Serin²,

Ayhan³

et al. 2016

Medicine

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To investigate the effects of physical agents on the levels of stress hormones in patients with osteoarthritis (OA).Transcutaneous electrical nerve stimulation, hot packs, and therapeutic ultrasound were applied to the lumbar region and knees of patients with OA. Blood samples were taken for the measurement of the serum levels of glucose, insulin (INS), growth hormone (GH), prolactin (PRL), cortisol (COR), and plasma adrenocorticotropic hormone (ACTH) immediately before and after the 1st session, to investigate the acute effects of those physical agents on the endocrine system. The hormone levels were also measured every 5 sessions in a total of 10 sessions. The treatment response was also evaluated by using the visual analogue scale (VAS), Roland Morris Disability Questionnaire (RMDQ), and Western Ontario and McMaster Universities Arthritis Index (WOMAC) throughout the therapy period.After the 1st session, there was a decrease in INS levels and a mild decrease in PRL levels (P = 0.001 and P < 0.05, respectively). Throughout the 10-session therapy period, the INS levels increased, whereas the ACTH and COR levels decreased (P < 0.05 for all). The VAS-spine, RMDQ, VAS-knee, and WOMAC scores decreased (P = 0.001 for VAS-spine and P < 0.001 for all others). A positive correlation was detected between the changes in serum COR and WOMAC-pain score (P < 0.05).Although the combination therapy caused changes in INS level accompanied with steady glucose levels, the application of physical agents did not adversely affect the hormone levels. The decrease in ACTH and COR levels may be attributed to the analgesic effect of agents and may be an indicator of patient comfort through a central action.

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Minimal immunoreactive plasma β-endorphin and decrease of cortisol at standard analgesia or different acupuncture techniques

Abstract: beta-endorphin immunoreactive material in blood is not released by any type of acupuncture as tested under low stress conditions.

Cited by 30 publications

References 26 publications

Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal α-adrenoceptors

Electroacupuncture-induced analgesia in a rat model of ankle sprain pain is mediated by spinal α-adrenoceptors

Expression of the endocannabinoid system in fibroblasts and myofascial tissues

The effects of physical therapeutic agents on serum levels of stress hormones in patients with osteoarthritis

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