Expression of the endocannabinoid system in fibroblasts and myofascial tissues

McPartland, John M.

doi:10.1016/j.jbmt.2008.01.004

Cited by 39 publications

(19 citation statements)

References 73 publications

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“…Another is perhaps through paracrine or endocrine pathways such as the cannabinoid system, which has a widespread regulating role, affecting myofascial tissues including fibroblast remodelling (McPartland, 2008). Cannabinoids have an important CNS role (perhaps related to mood changes) and are also linked to cardiovascular changes and smooth muscle relaxation (Ralevic et al, 2002), effects which have been linked with manual therapies.…”

Section: Non-neurological Mechanismsmentioning

confidence: 99%

A theoretical framework for the role of fascia in manual therapy

Simmonds

Miller

Gemmell

2012

Journal of Bodywork and Movement Therapies

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Section: Non-neurological Mechanismsmentioning

confidence: 99%

A theoretical framework for the role of fascia in manual therapy

Simmonds

Miller

Gemmell

2012

Journal of Bodywork and Movement Therapies

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“…Moreover, it is demonstrated that URB602 induces antiallodynic and anti-nociceptive effects in a rat model of neuropathic pain [18]. Besides, data mining via the GEO database (www.ncbi.nlm.nih.gov/geo/) reveals that fibroblasts, myofibroblasts, chondrocytes, and synoviocytes express endocannabinoid ligand-metabolizing enzymes [19]. Based on studies mentioned above, it is presumed that MGL may be involved in inflammatory reactions after skin injury.…”

Section: Introductionmentioning

confidence: 98%

Time-dependent expression and distribution of monoacylglycerol lipase during the skin-incised wound healing in mice

Fan

et al. 2011

Int J Legal Med

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The study investigated the expression of monoacylglycerol lipase (MGL) during the skin-incised wound healing in mice and applicability of the time-dependent expression of MGL to wound age determination by immunofluorescent staining, Western blotting, and real-time PCR. Furthermore, cell types were identified by double immunofluorescence. A total of 45 BALB/c male mice were used in this study. After a 1.5-cm-long incision in the central dorsum skin, mice were killed at intervals ranging from 6 h to 14 days, followed by the sampling of wound margin. In the control, there was a low-level expression of MGL in the epidermis, hair follicles, and glandulae sebaceae. In the injured skin, MGL immunoreactivity was mainly detected in the neutrophils, macrophages, and myofibroblasts. Morphometrically, the average ratios of MGL-positive cells were more than 50% at 5 and 7 days post-wounding, whereas it was <50% at the other posttraumatic intervals. By Western blotting analysis, the average ratio of MGL protein expression was highest at 5 days after injury, which had a ratio of >2.30. Similarly, the relative quantity of MGL mRNA expression maximized at posttraumatic 5 days in comparison with control as detected by real-time PCR, with an average ratio of >2.54. In conclusion, MGL expression is detected in neutrophils, macrophages, and myofibroblasts and significantly up-regulated, suggesting that it may play roles in response to inflammation during skin-incised wound healing. From the viewpoint of forensic pathology, MGL detection is applicable to skin wound age determination.

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“…There is a close relationship between the endocannabinoid or endorphin system and the fibroblasts. The cannabinoid receptor, or CB1, is mainly housed in the nervous system, but it can be found in the fascial system and in the fibroblasts as well, particularly near the neuromuscular junction 48. This relationship is believed to better manage any inflammation and pain information originating in the fascial tissue, as the fascia undergoes continuous remodeling during the day 48,49…”

Section: Symptoms: Facts and Hypothesesmentioning

confidence: 99%

Clinical and symptomatological reflections: the fascial system

Bordoni¹,

Zanier²

2014

JMDH

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Every body structure is wrapped in connective tissue, or fascia, creating a structural continuity that gives form and function to every tissue and organ. Currently, there is still little information on the functions and interactions between the fascial continuum and the body system; unfortunately, in medical literature there are few texts explaining how fascial stasis or altered movement of the various connective layers can generate a clinical problem. Certainly, the fascia plays a significant role in conveying mechanical tension, in order to control an inflammatory environment. The fascial continuum is essential for transmitting muscle force, for correct motor coordination, and for preserving the organs in their site; the fascia is a vital instrument that enables the individual to communicate and live independently. This article considers what the literature offers on symptoms related to the fascial system, trying to connect the existing information on the continuity of the connective tissue and symptoms that are not always clearly defined. In our opinion, knowing and understanding this complex system of fascial layers is essential for the clinician and other health practitioners in finding the best treatment strategy for the patient.

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Expression of the endocannabinoid system in fibroblasts and myofascial tissues

Cited by 39 publications

References 73 publications

A theoretical framework for the role of fascia in manual therapy

A theoretical framework for the role of fascia in manual therapy

Time-dependent expression and distribution of monoacylglycerol lipase during the skin-incised wound healing in mice

Clinical and symptomatological reflections: the fascial system

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