Miniaturized ionophore-based potentiometric sensors for the flow-injection determination of metformin in pharmaceutical formulations and biological fluids

Khaled, Elmorsy; Kamel, Manal S.; Hassan, Hassan N.; El-Alim, Sameh Hosam Abd; Aboul‐Enein, Hassan Y.

doi:10.1039/c2an35696a

Cited by 12 publications

(6 citation statements)

References 34 publications

(36 reference statements)

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“…Moreover, nanomaterials enhance of the hydrophobicity of the sensing membrane, which reflected to the more stable potential reading [51]. The present sensor showed high potential stability and need only for 20 min to achieve steady potential compared with 2 h for coated graphite electrodes and 24h for the corresponding PVC and carbon paste electrodes [52,53].…”

Section: Sensors Performancesmentioning

confidence: 80%

Novel Electroanalytical Technique for Determination of Trospium Hydrochloride

2020

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The present work describes for the first time the fabrication of a novel disposable screen printed sensor for the potentiometric determination of trospium hydrochloride (TRO). The cited sensors were based on alpha cyclodextrin as molecular recognition element and multi walled carbon nanotubes (MWCNTs) as transducer. Comprehensive and deep investigations were done on the sensing membrane components including the nature of sensing material, cavity size, additives, and plasticizers in addition to nanomaterial. The fabricated sensors were highly sensitive, selective and accurate towards TRO with Nernstian slope 60.8± 0.5 mV decade -1 in the concentration range from 10 -6 to 10 -2 mol L -1 . This can be attributed to the incorporation of MWCNTs to the electrode matrix which accelerates response time and improves potential reading stability. The fabricated sensors were used for the potentiometric determination of TRO under batch and flow injection technique with agreeable recoveries compared with the standard methods. Moreover, the high selectivity of the sensors towards TRO in presence of its degradation products suggests application of this method as stability indicating technique for TRO quality control.

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Section: Sensors Performancesmentioning

confidence: 80%

Novel Electroanalytical Technique for Determination of Trospium Hydrochloride

2020

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“…The result cocktail was printed on the surface of the graphite/PVC conducting track and left to dry at 50 o C for 24 h. The fabricated electrodes were used in potentiometric measurements after preconditioning in 10 ‐3 mol L ‐1 BP solutions for 10 min. For comparison, the above electrode matrix was applied for coating of graphite road following procedures described elsewhere .…”

Section: Methodsmentioning

confidence: 99%

Crown Ether/Carbon Nanotubes Based Biperiden Disposable Potentiometric Sensor

et al. 2016

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Sensitive disposable sensors have been constructed for potentiometric determination of Biperiden hydrochloride (BPHCl) based on multi‐walled carbon nanotubes–polyvinylchloride (MWNTs–PVC) composite in presence of dibenzo 24‐crown‐8‐ ether as a molecular receptor. Electrode matrix composition was optimized on the basis of the nature of the electroactive material, ionic sites, membrane plasticizer, and nanomaterial. The fabricated sensors showed improved selectivity and sensitivity towards biperiden hydrochloride with Nernstian cationic compliance of 59.8±1.1 mV decade−1 in the concentration range from 10−6 to 10−2 mol L−1. Modification with carbon nanotubes promote electron‐transfer processes and enhanced the stability of potential reading, response time and shelf lifetime of sensors. The proposed method was applied for potentiometric assay of BPHCl in dosage formulation and biological fluids under batch and flow injection analysis (FIA) with average recoveries agreeable with the reported official methods.

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“…The major analytical techniques used in metformin analysis include NMR [20], HPLC [21], GC [22], PVC matrix membrane sensors [23], UV-Vis [24], capillary electrophoresis [25], potentiometric titrations etc.24 However, many of these methods are only used in human biological samples and in pharmaceutical for purity determination and many of them are either time consuming or very expensive to run large samples [19].…”

Section: Fig 1 Structure Of Metformin Hydrochloridementioning

confidence: 99%

Remediation of Metformin Hydrochloride in Aqueous Solution Using Locally Sourced Seaweed (Fucus spiralis) Through HPLC

Bungudu

Murphy

2021

CSIJ

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Metformin hydrochloride is an anti-hyperglycaemic drug that is widely prescribed in the management of noninsulin diabetes mellitus (NIDDM). However, metformin does not undergo complete metabolism in the body thereby excreting significant amount through urine and eventual discharged into the water bodies. Therefore, this work investigates the possibility bio-sorption of metformin by Fucus spiralis seaweed. High performance liquid chromatography (HPLC) and FITR was used for quantifying metformin biosorption. The result shows that Fucus spiralis is a potential biosbent for metformin removal in aqueous solution. The highest removal was up to 74% at 50 µg/mL. It can be mentioned here that this study is the first of it kind in testing seaweed for metformin biosorption. In conclusion, biomass (Fucus spiralis) was tested for its efficiency in metformin removal in aqueous solution. Adsorption studies revealed that F. spiralis can be used as potential adsorbent for metformin uptake. Very limited literature investigates the application of seaweeds species for pharmaceutical remediation. Remediation of waste and surface water using readily available adsorbent such as seaweed will be useful as it relates to human health and environmental contamination. HPLC was used in this study but other spectroscopic technique such as UV/vis could be explored to ascertain the optimized method. Further studies would be needed to test other algal species for metformin bio sorption.

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Miniaturized ionophore-based potentiometric sensors for the flow-injection determination of metformin in pharmaceutical formulations and biological fluids

Cited by 12 publications

References 34 publications

Novel Electroanalytical Technique for Determination of Trospium Hydrochloride

Novel Electroanalytical Technique for Determination of Trospium Hydrochloride

Crown Ether/Carbon Nanotubes Based Biperiden Disposable Potentiometric Sensor

Remediation of Metformin Hydrochloride in Aqueous Solution Using Locally Sourced Seaweed (Fucus spiralis) Through HPLC

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