Crown Ether/Carbon Nanotubes Based Biperiden Disposable Potentiometric Sensor

Khaled, Elmorsy; Hassan, H. N. A.; Ahmed, Mohamed M. Z.; El-Attar, Rehab O.

doi:10.1002/elan.201600635

Cited by 12 publications

(7 citation statements)

References 38 publications

(45 reference statements)

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“…A new kinetic-potentiometric method for the characterization and analytical determination of competitive reversible enzyme inhibitors was developed [36]. Regarding other tested pharmaceutical compounds, only polyvinylchloride (PVC) sensors were found for donepezil [37], ipratropium [38,39] or biperdien [40,41]. The sited methods were linear in the concentration range from 10 -6 to 10 -2 mol L -1 of the corresponding drugs.…”

Section: Resultsmentioning

confidence: 99%

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

et al. 2018

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T HE PRESENT study described a novel application of simple potentiometric biosensors for analysis of anti-cholinesterase (Alzheimer) drugs in vitro. The proposed method was based on inhibition of acetylcholineesterase enzyme (AChE) by Alzheimer drugs namely; donepezil (DOP) and galantamine (GAL) in addition to biperdien (BP) and ipratropium (IPBr). Based on the relative inhibition action of drug on AChE activity, different sensitivities were recorded ranging between 0 to 18.0 ng, 0 to 90.0 ng, 0 to 4.69 µg and 0 to 9.96 µg mL -1 for the aforementioned drugs in the same order depending on the nature of drugs and their corresponding LD50 values. The proposed procedures were successfully applied for determination of drugs in pharmaceutical formulation and biological samples with sensitivity and accuracy comparable with the official method. The presented approach can be suggested for testing of pharmaceutical preparation toxicity against cholinesterase enzymes in vitro.

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Section: Resultsmentioning

confidence: 99%

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

et al. 2018

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“…Biperiden is used to treat Parkinsonism. The findings demonstrated improved response time, lifetime, sensitivity, selectivity, and the possibility of miniaturization of the sensor compared with γ-cyclodextrins, calixarenes, and buckminsterfullerene C 60 [71].…”

Section: Disposable Potentiometric Sensormentioning

confidence: 98%

Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications

et al. 2022

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Cyclic organic compounds with several ether linkages in their structure are of much concern in our daily life applications. Crown ethers (CEs) are generally heterocyclic and extremely versatile compounds exhibiting higher binding affinity. In recent years, due to their unique structure, crown ethers are widely used in drug delivery, solvent extraction, cosmetics manufacturing, material studies, catalysis, separation, and organic synthesis. Beyond their conventional place in chemistry, this review article summarizes the synthesis, biological, and potential pharmacological activities of CEs. We have emphasized the prospects of CEs as anticancer, anti-inflammatory, antibacterial, and antifungal agents and have explored their amyloid genesis inhibitory activity, electrochemical, and potential metric sensing properties. The central feature of these compounds is their ability to form selective and stable complexes with various organic and inorganic cations. Therefore, CEs can be used in gas chromatography as the stationary phase and are also valuable for cation chromatographic to determine and separate alkali and alkaline-earth cations.

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“…By applying the calibration line, it is possible to determine BIP concentrations in different samples in a range of 0.035-35.940 µmol dm -3 . When the determination range of the proposed method is compared with the methods presented in the Introduction section dealing with BIP determination in biological samples, one can see either it is at the upper limit of sensitivity [2][3][4][5] or the method is more sensitive for the same order of magnitude [6,7]. On the other hand, when compared with the methods for BIP determination in pharmaceutical formulations [8,9], the proposed procedure is capable to determine BIP in concentrations lower by 30 to 100 times, while in regard to the described spectrophotometric method [10], it is even 5000-fold more sensitive.…”

Section: Figure 2 Dixon's Diagram Of the Initial Enzymatic Reaction mentioning

confidence: 99%

“…Determination of BIP in human serum by liquid chromatography -electrospray ionization/mass spectrometry (ESI/MS), with an on-line sample clean-up procedure used, showed the limit of detection of 0.003 μmol dm -3 and determination range of 0.035-1.92 μmol dm -3 [5]. Sensitive disposable sensors have been constructed for potentiometric determination of BIP hydrochloride in dosage formulations and biological fluids, based on a multi-walled carbon nanotubes -polyvinylchloride (MWNTs-PVC) composite in the presence of dibenzo 24-crown-8-ether as a molecular receptor [6]. The method had the sensitivity range of 1-10000 μmol dm -3 , with the limit of detection of 0.1 μmol dm -3 [6].…”

Section: Introductionmentioning

confidence: 99%

“…Sensitive disposable sensors have been constructed for potentiometric determination of BIP hydrochloride in dosage formulations and biological fluids, based on a multi-walled carbon nanotubes -polyvinylchloride (MWNTs-PVC) composite in the presence of dibenzo 24-crown-8-ether as a molecular receptor [6]. The method had the sensitivity range of 1-10000 μmol dm -3 , with the limit of detection of 0.1 μmol dm -3 [6]. An interesting approach was based on using disposable pipette extraction with reversed-phase sorbent for the fast and simple GC determination of BIP in human urine, which gave detection limits of 0.90-1.36 μmol dm -3 (within-day and betweenday), quantification limits of 2.75-11.58 μmol/L (within-day and between-day), while the determination range was between 1.1 and 16.2 μmol dm -3 [7].…”

Section: Introductionmentioning

confidence: 99%

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A novel kinetic cholinesterase-inhibition based method for quantification of biperiden in pharmaceutical preparations

Djuric¹,

Mitić

Deletic³

et al. 2020

Hem Ind

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Biperiden, an antiparkinsonian anticholinergic drug, has been found to inhibit enzymatic hydrolysis of butyrylthiocholine iodide, which is catalyzed by serum cholinesterase. By measuring the difference in the basic and inhibitory hydrolysis reaction rates, in the presence of biperiden as an inhibitor, it is possible to develop a kinetic method for its determination. Both systems, enzyme-substrate-chromogen and enzyme-substrate-chromogen-inhibitor, were characterized by biochemical parameters (KM = 0.326 ? 0.330 mmol dm-3; Vmax = 40 - - 99 ?mol dm-3 min-1), while inhibition was defined as non-competitive with the constant of inhibition Ki = 6.142 ?mol dm-3. The reaction conditions have been optimized followed by determination of the calibration curve, the corresponding equation and the limits of detection and quantification yielding 3.84 and 12.80 nmol dm-3, respectively. Using the calibration chart, it is possible to determine biperiden in different samples in the concentration range of 0.035?35.940 ?mol dm-3. Influence of a number of substances, found in the sample, on the reaction rate was also examined. The optimized method was applied for determination of biperiden in pharmaceutical preparations. Accuracy of the method was tested using the standard addition method. The proposed method has good sensitivity, selectivity, it is simple and fast, and above all easily accessible, and thus applicable in biochemical and pharmaceutical laboratories.

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Crown Ether/Carbon Nanotubes Based Biperiden Disposable Potentiometric Sensor

Cited by 12 publications

References 38 publications

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

Highly sensitive enzymatic potentiometric approaches for anticholinesterase drugs rugs

Heterocyclic Crown Ethers with Potential Biological and Pharmacological Properties: From Synthesis to Applications

A novel kinetic cholinesterase-inhibition based method for quantification of biperiden in pharmaceutical preparations

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