Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display

Li, Jiawen; Ma, Teng; Jing, Joseph C.; Zhang, Jun; Patel, Pranav; Shung, K. Kirk; Zhou, Qifa; Chen, Zhongping

doi:10.1117/1.jbo.18.10.100502

Cited by 40 publications

(22 citation statements)

References 16 publications

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“…Significant effort has therefore been made to develop a novel combined IVUS-OCT catheter that can simultaneously generate images from the same arterial cross-sectional plane. Although the first generation of hybrid IVUS-OCT catheters were rather bulky [55] and suffered from spatial mismatches in image generation that precluded their use in vivo [56], further refinements to device technology has produced hybrid catheters that are \1.4 mm in diameter [57] yet ensuring automatically generated co-axial imaging [58]. Hopefully these technological advances will facilitate the development of a commercially available combined IVUS-OCT platform, which will allow improved atherosclerotic plaque characterization.…”

Section: Hybrid Ivus-oct Imagingmentioning

confidence: 98%

Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis

Costopoulos

Brown

Zhang

et al. 2015

Int J Cardiovasc Imaging

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Invasive imaging modalities, in particular intravascular ultrasound (IVUS) and optical coherence tomography (OCT), have become established tools for the in vivo study of coronary atherosclerosis. Their use in clinical studies has confirmed histopathological observations that certain important plaque features, such as thin fibrous caps and large lipid cores, are associated with plaque rupture, the precipitating event for the majority of myocardial infarctions. Serial imaging studies have also successfully been used for the evaluation of potential disease modifying pharmacological agents. Recent prospective IVUS studies have confirmed specific baseline imaging features associated with subsequent adverse clinical outcomes, although absolute event rates were too low for clinical utility. Development of hybrid IVUS-OCT imaging or integration of novel techniques, including near-infrared spectroscopy, plaque structural and endothelial shear stress, have great potential to improve our current ability to identify and stratify atheromatous plaques at risk of rupture.

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Section: Hybrid Ivus-oct Imagingmentioning

confidence: 98%

Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis

Costopoulos

Brown

Zhang

et al. 2015

Int J Cardiovasc Imaging

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“…This configuration enabled the catheter to provide automatically co-registered IVUS and OCT images fuesed in real time as well as to maintain a micro-dimension at 0.9 mm in OD and 1.5 mm in length (Figure 3). 54 However, the current integrated IVUS-OCT system needs further improvements prior to clinical trials. The current integrated IVUS-OCT catheter performs at only 20 fps, which is much lower than the commercial OCT imaging speed (>50 fps).…”

Section: Integrated Ivus and Oct Imaging Systemmentioning

confidence: 99%

“…(d) Schematic of cardiovascular system. Adapted from Li et al 54 OCT = optical coherence tomography; IVUS = intravascular ultrasound.…”

Section: Figurementioning

confidence: 99%

A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging

Zhou

Hsiai

et al. 2016

Ultrason Imaging

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Catheter-based intravascular imaging modalities are being developed to visualize pathologies in coronary arteries, such as high-risk vulnerable atherosclerotic plaques known as thin-cap fibroatheroma, to guide therapeutic strategy at preventing heart attacks. Mounting evidences have shown three distinctive histopathological features—the presence of a thin fibrous cap, a lipid-rich necrotic core, and numerous infiltrating macrophages—are key markers of increased vulnerability in atherosclerotic plaques. To visualize these changes, the majority of catheter-based imaging modalities used intravascular ultrasound (IVUS) as the technical foundation and integrated emerging intravascular imaging techniques to enhance the characterization of vulnerable plaques. However, no current imaging technology is the unequivocal “gold standard” for the diagnosis of vulnerable atherosclerotic plaques. Each intravascular imaging technology possesses its own unique features that yield valuable information although encumbered by inherent limitations not seen in other modalities. In this context, the aim of this review is to discuss current scientific innovations, technical challenges, and prospective strategies in the development of IVUS-based multi-modality intravascular imaging systems aimed at assessing atherosclerotic plaque vulnerability.

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“…A probe with a short rigid-part length can be flexible and easily navigated into a coronary artery. The most recently published back-to-back design [31] (see Gen 5 in Fig. 3) addressed the strict size requirements of OD and rigid-part length at the same time.…”

Section: Catheter Designsmentioning

confidence: 99%

Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]

Chen

2015

JBPE

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Heart attack is mainly caused by the rupture of a vulnerable plaque. IVUS-OCT is a novel medical imaging modality that provides opportunities for accurate assessment of vulnerable plaques in vivo in patients. IVUS provides deep penetration to image the whole necrotic core while OCT enables accurate measurement of the fibrous cap of a plaque owing to its high resolution. In this paper, the authors describe the fundamentals, the technical designs and the applications of IVUS-OCT technology. Results from cadaver specimens are summarized, which indicated the complementary nature of OCT and IVUS for assessment of vulnerable plaques, plaque composition, and stent-tissue interactions. Furthermore, previously reported in vivo animal experiments are reviewed to assess the clinical adaptability of IVUS-OCT. Future directions for this technology are also discussed in this review.

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Miniature optical coherence tomography-ultrasound probe for automatically coregistered three-dimensional intracoronary imaging with real-time display

Cited by 40 publications

References 16 publications

Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis

Intravascular ultrasound and optical coherence tomography imaging of coronary atherosclerosis

A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging

Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]

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