Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]

Li, Jiawen; Chen, Zhongping

doi:10.18287/jbpe-2015-1-4-209

Cited by 4 publications

(3 citation statements)

References 63 publications

(92 reference statements)

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“…Also, data collection is very straightforward if the FRET signal might be converted into the electrical one. Numerous wired detectors [31,32], which are already used in clinical practice, might be successfully applied for measuring electrical signals. In this section, we describe an example of a medical system for gathering local data about a human body state.…”

Section: Applications In Medical In-body Systemsmentioning

confidence: 99%

Signal generation and storage in FRET-based nanocommunications

Kmiecik

Wójcik

Kułakowski

et al. 2019

Nano Communication Networks

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The paper is concerned with Fӧrster Resonance Energy Transfer (FRET) considered as a mechanism for communication between nanodevices. Two solved issues are reported in the paper, namely: signal generation and signal storage in FRET-based nanonetworks. First, luciferase molecules as FRET transmitters which are able to generate FRET signals themselves, taking energy from chemical reactions without any external light exposure, are proposed. Second, channelrhodopsins as FRET receivers, as they can convert FRET signals into voltage, are suggested. Further, medical in-body systems where both molecule types might be successfully applied, are discussed. Luciferasechannelrhodopsin communication is modeled and its performance is numerically validated, reporting on its throughput, bit error rate, propagation delay and energy consumption. IntroductionWith the current rapid development of technology, electronic and mechanical devices can be much smaller than even a decade ago, at the same time gaining new operating functionalities. However, when the device scale goes to the size of single molecules, cooperation between such devices and contacting them from outside their networks become quite challenging issues. Fӧrster Resonance Energy Transfer (FRET), a phenomenon characterized by very small propagation delays and a good throughput, has already been proposed for nanocommunications [1] and has been proved to be an efficient mechanism for transferring data at nanodistances [2][3][4]. Research on FRET for nanocommunication purposes and its integration with other elements on nanoworld is though at an early stage.The main contribution of the paper is solving two issues that, until now, were not solved for FRETbased communications [5]. The first issue is concerned with FRET signal storage. A molecule receiving a FRET signal cannot hold it and the signal must quickly be released, usually emitting a photon. Here, we propose to use channelrhodopsins which are molecules that can be used as nanoconverters, changing FRET signals into a voltage which can be detected by other devices. The second issue concerns FRET signal generation. In FRET nanocommunication experiments so far, a FRET transmission was initiated by an external laser source, which is rather troublesome inside a human body. Instead, we propose bioluminescent luciferase molecules as FRET transmitters, which are able to generate FRET signals themselves, taking energy from chemical reactions. We further discuss medical in-body systems where such FRET-based communication between luciferases and channelrhodopsins might be applied. We consider a system of small vesicles, liposomes, circulating through human vascular system and collecting data about body condition. The data gathered by liposomes are delivered to a detector placed in a human vein. Data transmission is realized by a luciferase-channelrhodopsin FRET interface. We model layers of luciferase and channelrhodopsin molecules based on their molecular structures and then we use their spectral characteristics to assess the e...

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Section: Applications In Medical In-body Systemsmentioning

confidence: 99%

Signal generation and storage in FRET-based nanocommunications

Kmiecik

Wójcik

Kułakowski

et al. 2019

Nano Communication Networks

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“…The¯rst design of an IVUS-OCT system was demonstrated in 2010. [35][36][37][38][39] Currently, several companies are in the process of commercializing IVUS-OCT technology, including Conavi Medical, Inc. and OCT Medical Imaging, Inc. Figure 1(a) depicts a typical IVUS-OCT system design. The trigger signal from the sweptsource laser is used to synchronize the short acoustic pulse emission as well as the data acquisition of IVUS and IVOCT.…”

Section: System Designmentioning

confidence: 99%

Multimodal intravascular imaging technology for characterization of atherosclerosis

Chen

2019

J. Innov. Opt. Health Sci.

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Early detection of vulnerable plaques is the critical step in the prevention of acute coronary events. Morphology, composition, and mechanical property of a coronary artery have been demonstrated to be the key characteristics for the identification of vulnerable plaques. Several intravascular multimodal imaging technologies providing co-registered simultaneous images have been developed and applied in clinical studies to improve the characterization of atherosclerosis. In this paper, the authors review the present system and probe designs of representative intravascular multimodal techniques. In addition, the scientific innovations, potential limitations, and future directions of these technologies are also discussed.

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“…IVUS is today a widely used method in clinics. Another intravascular imaging method, optical coherence tomography (OCT), has a lower penetration depth but a better axial resolution of 10 m [5]. Even though flushing of the artery is necessary due to strong signal attenuation through blood, compared to IVUS, OCT offers better assessment of the atherosclerotic plaques.…”

Section: Introductionmentioning

confidence: 99%

Characterization of Carotid Atherosclerotic Plaques by Measurement of Acoustic Impedance

Bilen

Kafa

Ünlü

2018

Celal Bayar Üniversitesi Fen Bilimleri Dergisi

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In this study, acoustic properties of carotid atherosclerotic plaques are studied ex vivo by scanning acoustic microscope (SAM). Human carotid atherosclerotic plaques were collected from patients by carotid erdarterectomy operation technique. An 80 MHz transducer was used in SAM, during the observation of the plaques. For the fibrous tissue, acoustic impedance was measured as 2.02  0.06 MRayl, while for the lipid pool it was measured as 1.70  0.07 MRayl and for the calcified region within the intima it was measured as 2.23  0.09 MRayl. The difference in acoustic impedance values is due to the variation of elasticity within the atherosclerotic plaques. Lipid pool, together with fibrous tissue and calcified regions are the indications of vulnerable plaques, therefore, the determination of these regions within the plaques by SAM will help to evaluate the risk of thrombosis or stenosis and effect the decision making of the operations of the patients.

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Integrated intravascular ultrasound and optical coherence tomography technology: a promising tool to identify vulnerable plaques [INVITED PAPER]

Cited by 4 publications

References 63 publications

Signal generation and storage in FRET-based nanocommunications

Signal generation and storage in FRET-based nanocommunications

Multimodal intravascular imaging technology for characterization of atherosclerosis

Characterization of Carotid Atherosclerotic Plaques by Measurement of Acoustic Impedance

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