Abstract:Early detection of vulnerable plaques is the critical step in the prevention of acute coronary events. Morphology, composition, and mechanical property of a coronary artery have been demonstrated to be the key characteristics for the identification of vulnerable plaques. Several intravascular multimodal imaging technologies providing co-registered simultaneous images have been developed and applied in clinical studies to improve the characterization of atherosclerosis. In this paper, the authors review the pre… Show more
“…To address this challenge, multi-modality intravascular imaging that combines different imaging techniques with complementary strengths into advanced images has been proposed and developed. Since the multimodal intravascular imaging technology has been reviewed extensively by many researchers [21,[181][182][183][184], in this section, we concentrate on the reported applications of IVUS-based dual-modality intravascular imaging including IVUS-OCT, IVUS-NIRS, IVUS-IVPA, IVUS-NIRF, IVUS-TRFS (FLIM) and tri-modality intravascular imaging including IVUS-OCT-NIRF and IVUS-OCT-IVPA. Representative dual-modality and tri-modality intravascular imaging systems are demonstrated in Figure 10.…”
As a well-known medical imaging methodology, intravascular ultrasound (IVUS) imaging plays a critical role in diagnosis, treatment guidance and post-treatment assessment of coronary artery diseases. By cannulating a miniature ultrasound transducer mounted catheter into an artery, the vessel lumen opening, vessel wall morphology and other associated blood and vessel properties can be precisely assessed in IVUS imaging. Ultrasound transducer, as the key component of an IVUS system, is critical in determining the IVUS imaging performance. In recent years, a wide range of achievements in ultrasound transducers have been reported for IVUS imaging applications. Herein, a comprehensive review is given on recent advances in ultrasound transducers for IVUS imaging. Firstly, a fundamental understanding of IVUS imaging principle, evaluation parameters and IVUS catheter are summarized. Secondly, three different types of ultrasound transducers (piezoelectric ultrasound transducer, piezoelectric micromachined ultrasound transducer and capacitive micromachined ultrasound transducer) for IVUS imaging are presented. Particularly, the recent advances in piezoelectric ultrasound transducer for IVUS imaging are extensively examined according to their different working mechanisms, configurations and materials adopted. Thirdly, IVUS-based multimodality intravascular imaging of atherosclerotic plaque is discussed. Finally, summary and perspectives on the future studies are highlighted for IVUS imaging applications.
“…To address this challenge, multi-modality intravascular imaging that combines different imaging techniques with complementary strengths into advanced images has been proposed and developed. Since the multimodal intravascular imaging technology has been reviewed extensively by many researchers [21,[181][182][183][184], in this section, we concentrate on the reported applications of IVUS-based dual-modality intravascular imaging including IVUS-OCT, IVUS-NIRS, IVUS-IVPA, IVUS-NIRF, IVUS-TRFS (FLIM) and tri-modality intravascular imaging including IVUS-OCT-NIRF and IVUS-OCT-IVPA. Representative dual-modality and tri-modality intravascular imaging systems are demonstrated in Figure 10.…”
As a well-known medical imaging methodology, intravascular ultrasound (IVUS) imaging plays a critical role in diagnosis, treatment guidance and post-treatment assessment of coronary artery diseases. By cannulating a miniature ultrasound transducer mounted catheter into an artery, the vessel lumen opening, vessel wall morphology and other associated blood and vessel properties can be precisely assessed in IVUS imaging. Ultrasound transducer, as the key component of an IVUS system, is critical in determining the IVUS imaging performance. In recent years, a wide range of achievements in ultrasound transducers have been reported for IVUS imaging applications. Herein, a comprehensive review is given on recent advances in ultrasound transducers for IVUS imaging. Firstly, a fundamental understanding of IVUS imaging principle, evaluation parameters and IVUS catheter are summarized. Secondly, three different types of ultrasound transducers (piezoelectric ultrasound transducer, piezoelectric micromachined ultrasound transducer and capacitive micromachined ultrasound transducer) for IVUS imaging are presented. Particularly, the recent advances in piezoelectric ultrasound transducer for IVUS imaging are extensively examined according to their different working mechanisms, configurations and materials adopted. Thirdly, IVUS-based multimodality intravascular imaging of atherosclerotic plaque is discussed. Finally, summary and perspectives on the future studies are highlighted for IVUS imaging applications.
“…The micromotor rotates the mirror for circumferential beam scanning. The micromotor-based beam scanning is advantageous in terms of imaging speed and imaging quality (non-uniform rotation distortion free) compared to the method based on a fiber rotary joint 43 – 45 . Figure 6 The schematic ( a ) and photo ( b ) of IV-PSOCT imaging probe.…”
Intravascular polarization-sensitive optical coherence tomography (IV-PSOCT) provides depth-resolved tissue birefringence which can be used to evaluate the mechanical stability of a plaque. In our previous study, we reported a new strategy to construct polarization-sensitive optical coherence tomography in a microscope platform. Here, we demonstrated that this technology can be implemented in an endoscope platform, which has many clinical applications. A conventional intravascular OCT system can be modified for IV-PSOCT by introducing a 12-m polarization-maintaining fiber-based imaging probe. Its two polarization modes separately produce OCT images of polarization detection channels spatially distinguished by an image separation of 2.7 mm. We experimentally validated our IV-PSOCT with chicken tendon, chicken breast, and coronary artery as the image samples. We found that the birefringent properties can be successfully visualized by our IV-PSOCT.
“…IVPA imaging integrated with IVUS provides both structure and chemical compositions of arterial walls, which demonstrates the capability of characterizing vulnerable plaque [ 99 ]. The combination of IVUS and OCT imaging systems (IVUS-OCT) could provide high resolution and large penetration depth, visualizing the plaque structural information on different spatial scales [ 109 ]. The tri-modality IVOCT-PA-US provides depth-resolved molecular contrast and morphology of coronary arteries without the use of a contrast agent, which has been demonstrated and tested in human arteries ex vivo [ 110 ].…”
Section: Research Progress and Applications Of Laser Technology In Intravascular Imaging And Treatmentmentioning
Blood vessels are one of the most essential organs, which nourish all tissues in our body. Once there are intravascular plaques or vascular occlusion, other organs and circulatory systems will not work properly. Therefore, it is necessary to detect abnormal blood vessels by intravascular imaging technologies for subsequent vascular treatment. The emergence of lasers and fiber optics promotes the development of intravascular imaging and treatment. Laser imaging techniques can obtain deep vascular images owing to light scattering and absorption properties. Moreover, photothermal and photomechanical effects of laser make it possible to treat vascular diseases accurately. In this review, we present the research progress and applications of laser techniques in intravascular imaging and treatment. Firstly, we introduce intravascular optical coherent tomography and intravascular photoacoustic imaging, which can obtain various information of plaques. Multimodal intravascular imaging techniques provide more information about intravascular plaques, which have an essential influence on intravascular imaging. Secondly, two laser techniques including laser angioplasty and endovenous laser ablation are discussed for the treatment of arterial and venous diseases, respectively. Finally, the outlook of laser techniques in blood vessels, as well as the integration of laser imaging and treatment are prospected in the section of discussions.
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