A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging

Ma, Teng; Zhou, Bill; Hsiai, Tzung K.; Shung, K. Kirk

doi:10.1177/0161734615604829

Cited by 51 publications

(32 citation statements)

References 80 publications

(104 reference statements)

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“…Importantly, the incidence of an acute coronary event is determined by the extent and severity of the luminal stenosis, especially the characteristics of the plaque [12]. intravascular ultrasound (IVUS) has been developed to access plaque composition and define atherosclerotic lesion phenotype [13]. Classical greyscale IVUS has now been expanded with spectral analysis of back scattered radio frequency (RF) data.…”

Section: Introductionmentioning

confidence: 99%

Coronary plaque tissue characterization in patients with premature coronary artery disease

Xie

Mao

et al. 2020

Int J Cardiovasc Imaging

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Premature coronary artery disease (CAD) studies rarely involve coronary plaque characterization. We characterize coronary plaque tissue by radiofrequency intravascular ultrasound (IVUS) in patients with premature CAD. From July 2015 to December 2017, 220 patients from the Department of Cardiology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine with first occurrence of angina or myocardial infarction within 3 months were enrolled. Patients with premature CAD (n = 47, males aged < 55 years, and females aged < 65 years) or later CAD (n = 155) were retrospectively compared for cardiovascular risk factors, laboratory examination findings, coronary angiography data, gray-scale IVUS, and iMap-IVUS. The mean age was 53.53 ± 7.24 vs. 70.48 ± 8.74 years (p < 0.001). The groups were similar for traditional coronary risk factors except homocysteine (18.60 ± 5.15 vs. 17.08 ± 4.27 µmol/L, p = 0.043). After matching for baseline characteristics, LDL cholesterol (LDL-C) was higher for premature CAD than later CAD (2.50 ± 0.96 vs. 2.17 ± 0.80 mmol/L, p = 0.019). Before the matching procedure, the premature CAD group had shorter target lesion length [18.50 (12.60-32.00) vs. 27.90 (18.70-37.40) mm, p = 0.002], less plaque volume [175.59 (96.60-240.50) vs. 214.73 (139.74-330.00) mm 3 , p = 0.013] than the later CAD group. After the matching procedure, the premature CAD group appeared to be less plaque burden (72.69 ± 9.99 vs. 74.85 ± 9.80%, p = 0.005), and positive remodeling (1.03 ± 0.12 vs. 0.94 ± 0.18, p = 0.034), and lower high risk feature incidence (p = 0.006) than the later CAD group. At the plaque's minimum lumen, premature CAD had more fibrotic (p < 0.001), less necrotic (p = 0.001) and less calcified areas (p = 0.012). Coronary plaque tissue was more fibrotic with less necrotic and calcified components in premature than in later CAD, and the range and degree of atherosclerosis were significantly lower.

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Section: Introductionmentioning

confidence: 99%

Coronary plaque tissue characterization in patients with premature coronary artery disease

Xie

Mao

et al. 2020

Int J Cardiovasc Imaging

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“…Aside from this, the IVUS technique can be helpful in visualizing some internal structures of the human coronary such as the lumen, and thickness and distribution of the plaques [2]. Therefore, IVUS is regularly used to locate the atherosclerosis lesions in the coronary arteries to study the lumen and plaque dimensions, and to guide intervention and stent deployment [3].…”

Section: Introductionmentioning

confidence: 99%

Segmentation of arterial walls in intravascular ultrasound cross-sectional images using extremal region selection

Faraji

Cheng

Naudin³

et al. 2018

Ultrasonics

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Intravascular Ultrasound (IVUS) is an intra-operative imaging modality that facilitates observing and appraising the vessel wall structure of the human coronary arteries. Segmentation of arterial wall boundaries from the IVUS images is not only crucial for quantitative analysis of the vessel walls and plaque characteristics, but is also necessary for generating 3D reconstructed models of the artery. The aim of this study is twofold. Firstly, we investigate the feasibility of using a recently proposed region detector, namely Extremal Region of Extremum Level (EREL) to delineate the luminal and media-adventitia borders in IVUS frames acquired by 20 MHz probes. Secondly, we propose a region selection strategy to label two ERELs as lumen and media based on the stability of their textural information. We extensively evaluated our selection strategy on the test set of a standard publicly available dataset containing 326 IVUS B-mode images. We showed that in the best case, the average Hausdorff Distances (HD) between the extracted ERELs and the actual lumen and media were 0.22  mm and 0.45 mm, respectively. The results of our experiments revealed that our selection strategy was able to segment the lumen with ⩽0.3 mm HD to the gold standard even though the images contained major artifacts such as bifurcations, shadows, and side branches. Moreover, when there was no artifact, our proposed method was able to delineate media-adventitia boundaries with 0.31 mm HD to the gold standard. Furthermore, our proposed segmentation method runs in time that is linear in the number of pixels in each frame. Based on the results of this work, by using a 20 MHz IVUS probe with controlled pullback, not only can we now analyze the internal structure of human arteries more accurately, but also segment each frame during the pullback procedure because of the low run time of our proposed segmentation method.

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“…Patients with a history of heart disease or with risk factors associated with plaque progression (e.g., diabetes or hypertension) could be ideal candidates for early imaging and treatment. Multiple imaging modalities are being developed, and sometimes combined, to meet this need, with each modality having its own distinct advantages and disadvantages [7][8][9][10]. One such modality is intravascular photoacoustics.…”

Section: Introductionmentioning

confidence: 99%

Laser threshold and cell damage mechanism for intravascular photoacoustic imaging

Sowers

VanderLaan²,

Karpiouk³

et al. 2018

Lasers Surg Med

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Objectives Intravascular photoacoustic (IVPA) imaging is being developed to image atherosclerotic plaques, a leading cause of morbidity and mortality in the United States. However, the safety of this imaging modality, which requires repeated irradiation with short laser pulses, has not yet been investigated. This study has two objectives. First, determine in vitro the limit of cumulative fluence that can be applied to cells before death at IVPA relevant wavelengths. Second, evaluate if high single pulse fluences are a potential cause of cell death during IVPA imaging. Materials and Methods Experiments were conducted using endothelial cells, macrophages, and smooth muscle cells. The cumulative fluence experiments were conducted at 1064 and 1197 nm, using a high pulse repetition frequency laser. Cells were irradiated with a wide range of cumulative fluences and evaluated for cell death. The thresholds for death were compared to the maximum expected clinical cumulative fluence. To evaluate the effect of single pulse fluences, cells were irradiated at 1064, 1210, and 1720 nm. Light was delivered at a range of pulse energies to emulate the fluences that cells would be exposed to during clinical IVPA imaging. Results At 1064 nm, all three cell types remained viable at cumulative fluences above the maximum expected clinical cumulative fluence, which is calculated based on common IVPA imaging protocols. At 1197 nm, cells were viable near or just below the maximum expected clinical cumulative fluence, with some cell type to cell type variation. All three cell types remained viable after irradiation with high single pulse fluences at all three wavelengths. Conclusion The cumulative fluence experiments indicate that safety considerations are likely to put constraints on the amount of irradiation that can be used in IVPA imaging protocols. However, this study also indicates that it will be possible to use IVPA imaging safely, since cumulative fluences could be reduced by as much as two orders of magnitude below the maximum expected clinical cumulative fluence by varying the imaging protocol, albeit at the expense of image quality. The single pulse fluence experiments indicate that cell death from single pulse fluence is not likely during IVPA imaging. Thus, future studies should focus on heat accumulation as the likely mechanism of tissue damage. Lasers Surg. Med. 51:466–474, 2019. © 2018 Wiley Periodicals, Inc.

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A Review of Intravascular Ultrasound-based Multimodal Intravascular Imaging

Cited by 51 publications

References 80 publications

Coronary plaque tissue characterization in patients with premature coronary artery disease

Coronary plaque tissue characterization in patients with premature coronary artery disease

Segmentation of arterial walls in intravascular ultrasound cross-sectional images using extremal region selection

Laser threshold and cell damage mechanism for intravascular photoacoustic imaging

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