Miniature brain in spine: the ‘mini brain sign’ in vertebral plasmacytoma

Gupta, Ranjana; Mittal, Amit; Mittal, Prabhat; Kaur, Harkirat; Sachdeva, Vanie; Mirchia, Kavya

doi:10.1136/postgradmedj-2016-134197

Cited by 7 publications

(9 citation statements)

References 3 publications

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“…A "spoke-wheel" pattern has also been described. [6][7][8][9][10][11][12] The characteristic appearance of thickened cortical struts may be due to chronic bone marrow compromise by disease with secondary compensation of bone strengthening in the cortical layer. This phenomenon is also described in Paget´s disease and hemangiomas, however in these cases, the "mini brain" pattern is not seen.…”

Section: Discussionmentioning

confidence: 99%

“…Among the 12, only six were specific for radiological image patterns for MM/plasmocytoma. [6][7][8][9][10][11][12] Sha et al reported a characteristic appearance in four cases out of six patients with plasmacytoma. MRI features were curvilinear areas of low signal intensity within the vertebra and/or cortical irregularity.…”

Section: Reviewmentioning

confidence: 99%

“…Radiological diagnosis based on a finding of "mini brain" was subsequently supported by a pathological report. 12…”

Section: Plasmocytoma-mm 11%mentioning

confidence: 99%

“…[1][2][3][4][5] "Mini brain" image pattern has been identified as a radiological sign to diagnose MM and solitary plasmacytomas in magnetic resonance (MRI). [6][7][8][9][10][11][12] Axial T2-weighted images of the T12 vertebral body highlight the cortical and radiated pattern ("mini brain" sign). However, there is still very little data on the frequency with which it can be observed and the real diagnostic accuracy.…”

Section: Introductionmentioning

confidence: 99%

“…However, there is still very little data on the frequency with which it can be observed and the real diagnostic accuracy. [6][7][8][9][10][11][12] In this study, we present our series, discuss the sensitivity and specificity of "mini brain" in the diagnosis of MM/plasmacytoma, and conduct a review of the current literature.…”

Section: Introductionmentioning

confidence: 99%

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Sensitivity and Specificity of "Mini Brain" Image Pattern to Diagnose Multiple Myeloma and Plasmacytoma

et al. 2018

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Introduction: “Mini brain” image pattern has been identified as a radiological sign for diagnosing multiple myeloma (MM) and solitary plasmacytomas in magnetic resonance imaging (MRI). However, there is still very little data on the frequency with which it can be observed, and its real diagnostic accuracy. Objetive: In this study, we present our case series, discuss sensitivity and specificity of “mini brain” in the diagnosis of multiple myeloma (MM)/plasmacytoma, and conduct a literature review. Methods: The study sample consisted of asymptomatic and/or symptomatic patients consecutively diagnosed with expansive vertebral disease. Patients were evaluated with MRI. A literature review was conducted on the relationship of the radiological sign “mini brain” and the diagnosis of multiple myeloma (MM) or plasmacytoma. Results: Forty-seven patients were evaluated consecutively. Among five patients diagnosed with multiple myeloma, four had an MRI pattern of “mini brain”. The sensitivity of “mini brain” was 80%. The specificity was 97.6%. The accuracy was 95.8%. Sensitivity and specificity were 100% when we considered differential diagnoses only with neoplastic lesions involving the spine. Conclusions: “Mini brain” is a feasible and reliable sign for the diagnosis of multiple myeloma /plasmacytoma, guiding physicians for adequate screening and treatment. Nevertheless, it should not replace pathological investigation after vertebral biopsy. Level of Evidence III; Study of case: Case-control study.

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Section: Discussionmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

“…Radiological diagnosis based on a finding of "mini brain" was subsequently supported by a pathological report. 12…”

Section: Plasmocytoma-mm 11%mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sensitivity and Specificity of "Mini Brain" Image Pattern to Diagnose Multiple Myeloma and Plasmacytoma

et al. 2018

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The “Mini Brain” Sign in a Case of Vertebral Hemangioma Mimicking Solitary Plasmacytoma of the Spine

et al. 2019

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Solitary bone plasmacytoma of spine with involvement of adjacent disc space

Tan

et al. 2021

Medicine

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Rationale Solitary bone plasmacytoma (SBP) is a rare manifestation of plasma cell tumor. Although axial skeleton is the most frequently affected site of SBP, adjacent disc space involvement is rare. Herein we report a case of SBP in thoracic vertebra with involvement of adjacent disc space. Patient concerns A 57-year-old male presented with a 2-year history of intermittent back pain with activity. The patient's back pain intensity with activity was a score of 5 of the 10-point visual analog scale). Diagnoses and intervention The patient underwent a posterior fusion procedure from T6 to T10, and an open biopsy of the vertebral lesion confirmed that final diagnosis of SBP. The patient received postoperative radiotherapy with a total of 4000 Gy to the T7–T9 vertebral levels over a 20-day period. Outcomes Following radiotherapy, the patient's pain intensity was reduced to the visual analog scale score of 1 at the 6-month follow-up. Lessons SBP lacks typical clinical symptoms, and the accurate diagnosis before clinical intervention remains challenging. Due to the disc involvement, SBP often manifests as spinal infection. Hence, differential diagnosis in spinal lesions involving the disc should include SBP.

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Miniature brain in spine: the ‘mini brain sign’ in vertebral plasmacytoma

Cited by 7 publications

References 3 publications

Sensitivity and Specificity of "Mini Brain" Image Pattern to Diagnose Multiple Myeloma and Plasmacytoma

Sensitivity and Specificity of "Mini Brain" Image Pattern to Diagnose Multiple Myeloma and Plasmacytoma

The “Mini Brain” Sign in a Case of Vertebral Hemangioma Mimicking Solitary Plasmacytoma of the Spine

Solitary bone plasmacytoma of spine with involvement of adjacent disc space

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