Mineralized vectors for gene therapy

Biomineralized Polydopamine Nanoparticle-Based Sodium Alginate Hydrogels for Delivery of Anti-serine/Threonine Protein Kinase B-Rapidly Accelerated Fibrosarcoma siRNA for Metastatic Melanoma Therapy

“…Thus, various delivery systems have been developed to overcome these obstacles and maximize the therapeutic efficacy of siRNA, such as liposomes, dendrimers, polymeric nanoparticles, and viral vectors. − Of the many approaches developed for drug delivery, biomimetic mineralization is a method that seeks to mimic the natural process of mineralization in biological systems. Customized drug delivery vehicles can be created through this approach, which possess improved biocompatibility and targeted drug release properties. , In particular, the strategy of incorporating siRNA within mineral materials can protect the siRNA from degradation by ribonuclease (RNase), with high transfection efficiency and biocompatibility . Thus, biomimetic mineralization-based siRNA delivery systems have the potential to revolutionize melanoma therapy, ultimately leading to more effective treatments and higher survival rates for patients with metastatic melanoma.…”

“…14,15 In particular, the strategy of incorporating siRNA within mineral materials can protect the siRNA from degradation by ribonuclease (RNase), with high transfection efficiency and biocompatibility. 16 Thus, biomimetic mineralization-based siRNA delivery systems have the potential to revolutionize melanoma therapy, ultimately leading to more effective treatments and higher survival rates for patients with metastatic melanoma.…”