Equilibrium interactions of biomimetic DNA aptamers produce intrafibrillar calcium phosphate mineralization of collagen

Patoine, Kassidy; Ta, Kristy; Gilbert, Amanda; Percuoco, Marielle; Gerdon, Aren E.

doi:10.1016/j.actbio.2024.03.018

Cited by 1 publication

(1 citation statement)

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“…This system utilizes bio-inspired artificial materials to stabilize intermediate mineral phases involved in biomineralization. This system employs poly-aspartic acid and polyacrylic acid to replicate the mechanisms of NCPs [ 56 ], while recent studies have also utilized synthetic DNA aptamers with specific secondary structures for collagen mineralization [ 57 ]. By increasing the concentration of mineral ions and polymeric additives, the CaP-PILP system achieves a viscous and transparent material with good fluidity, enabling it to penetrate and mineralize osteoporotic bone efficiently, resembling the natural mineralization processes in bone tissue.…”

Section: Biomineralsmentioning

confidence: 99%

Biomineral-Based Composite Materials in Regenerative Medicine

Kim,

Ki,

Han

et al. 2024

IJMS

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Regenerative medicine aims to address substantial defects by amplifying the body’s natural regenerative abilities and preserving the health of tissues and organs. To achieve these goals, materials that can provide the spatial and biological support for cell proliferation and differentiation, as well as the micro-environment essential for the intended tissue, are needed. Scaffolds such as polymers and metallic materials provide three-dimensional structures for cells to attach to and grow in defects. These materials have limitations in terms of mechanical properties or biocompatibility. In contrast, biominerals are formed by living organisms through biomineralization, which also includes minerals created by replicating this process. Incorporating biominerals into conventional materials allows for enhanced strength, durability, and biocompatibility. Specifically, biominerals can improve the bond between the implant and tissue by mimicking the micro-environment. This enhances cell differentiation and tissue regeneration. Furthermore, biomineral composites have wound healing and antimicrobial properties, which can aid in wound repair. Additionally, biominerals can be engineered as drug carriers, which can efficiently deliver drugs to their intended targets, minimizing side effects and increasing therapeutic efficacy. This article examines the role of biominerals and their composite materials in regenerative medicine applications and discusses their properties, synthesis methods, and potential uses.

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Section: Biomineralsmentioning

confidence: 99%