Mineralized Scaffolds for Hard Tissue Engineering by Ionotropic Gelation of Alginate

Continuous Delivery of Stromal Cell-Derived Factor-1 from Alginate Scaffolds Accelerates Wound Healing

“…Alginate gels were prepared accord-(PDGF) and epidermal growth factor (EGF) (20). Our ing to the method described previously (8). Briefly, sostudy focused on stromal cell-derived factor-1 (SDF-1), dium alginate (MW, 110k, Wako Pure Chemical Industry, a naturally occurring chemokine that is rapidly overexOsaka, Japan) was dissolved at different concentrations in pressed in response to tissue injury, particularly during distilled water.…”

Novel Biomaterials with Parallel Aligned Pore Channels by Directed Ionotropic Gelation of Alginate: Mimicking the Anisotropic Structure of Bone Tissue

“…The pore distribution and run was characterized by µCT in ceramic (Goebbels et al, 2002) or composite (Despang et al, 2005b) state. Since 2005/6, the anisotropic structures have been subject of research in the area of tissue engineering with human cells for hard tissue (Despang et al, 2005a, Dittrich et al, 2006 and vascularisation (Yamamoto et al, 2010), in in vitro and in vivo studies in rats for nerve regeneration and with murine embryonic stem cells opening opportunities for the formation of many types of tissue (Willenberg et al, 2006). A more detailed and chronological list of scientific contributions to the field with short summaries of their content follows (Table 1).…”

“…precipitation of calcium phosphate during the sol-gelprocess ), • HAP powder, i.e. addition of HAP powder to the alginate sol and structuring of this slurry via ionotropic gelation Dittrich et al, 2006;Dittrich et al, 2007;Bernhardt et al, 2009), • Biphasic but monolithic scaffolds for the therapy of osteochondral defects can be produced through deposition of sol layers differing in composition prior to the gelation .…”

Development of bioactive glass based scaffolds for controlled antibiotic release in bone tissue engineering via biodegradable polymer layered coating

“…44 After coating with PDLLA/P123 blend, the contact angle value of the scaffolds was significantly decreased (from 74. 3 6 0.2 for pure PDLLA-c-BG to 31 6 2 for PDLLA/P123-c-BG) to nearly the values of T-Alg and T-Gel coatings (38.0 6 0.5 and 39 6 0 , respectively). These results confirmed that the blend of PDLLA and P123 copolymer can drastically modify the surface chemistry of pure PDLLA and thus the TCH-loaded alginate and gelatin solutions could efficiently infiltrate the porous structure of the scaffolds, forming layered polymer coatings, as desired in this study.…”

“…13 This is particularly the case for bioactive glass scaffolds derived from molten glasses, [20][21][22][23] which do not have a suitable intrinsic mesoporosity to be used as drug reservoirs. 3,10 Therefore, several natural-and synthetic-derived biodegradable polymers have been explored as the organic component for development of composite scaffolds, such as collagen, [24][25][26] gelatin, [27][28][29] chitosan, 2,18,19,30 alginate, [29][30][31] and polyesters. 16,[32][33][34][35] As early reported by Yaylao glu et al, 17 CaP/gelatin composite scaffolds have been loaded with gentamicin for in-situ drug delivery enhanced bone tissue engineering.…”