Mineralized Human Amniotic Membrane as a Biomimetic Scaffold for Hard Tissue Engineering Applications

Sabouri, Leila; Farzin, Ali; Kabiri, Azadeh; Milan, Peiman Brouki; Farahbakhsh, Mojtaba; Mehdizadehkashi, Abolfazl; Kajbafzadeh, Abdol‐Mohammad; Samadikuchaksaraei, Alí; Yousefbeyk, Fatemeh; Azami, Mahmoud; Moghtadaei, Mehdi

doi:10.1021/acsbiomaterials.0c00881

Cited by 14 publications

(21 citation statements)

References 54 publications

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“…The resulting scaffold associated with the mineralized extracellular matrix by the differentiated ASCs provided osteogenic proteins, such as OPN, as reported by others [ 48 , 49 ]. The pre-osteoinduction of transplanted cells stimulated ECM deposition, cell differentiation [ 50 ], and guaranteed the preparation of cell sheets for clinical transplantation [ 7 ].…”

Section: Discussionsupporting

confidence: 61%

“…The mineralization of collagen scaffolds stimulated cell proliferation and differentiation in vitro, and bone regeneration in calvarial defects [ 51 ], with a higher bone regeneration with cell-seeded mineralized DAM, compared to cell-seeded non-mineralized DAM [ 49 ]. The DAM with mineralized ECM did not impair osteoconduction and the presence of the mineralized tissue and bone proteins may even promote osteoinduction [ 49 , 52 , 53 ], directing endogenous cell differentiation.…”

Section: Discussionmentioning

confidence: 99%

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Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Dziedzic¹,

Mogharbel²,

Irioda³

et al. 2021

Membranes

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Periodontitis is a prevalent disease characterized by the loss of periodontal supporting tissues, bone, periodontal ligament, and cementum. The application of a bone tissue engineering strategy with Decellularized Human Amniotic Membrane (DAM) with adipose-derived stromal cells (ASCs) has shown to be convenient and valuable. This study aims to investigate the treatments of a rat periodontal furcation defect model with DAM, ASCs, and a mineralized extracellular matrix (ECM). Rat ASCs were expanded, cultivated on DAM, and with a bone differentiation medium for four weeks, deposited ECM on DAM. Periodontal healing for four weeks was evaluated by micro-computed tomography and histological analysis after treatments with DAM, ASCs, and ECM and compared to untreated defects on five consecutive horizontal levels, from gingival to apical. The results demonstrate that DAM preserves its structure during cultivation and healing periods, supporting cell attachment, permeation, bone deposition on DAM, and periodontal regeneration. DAM and DAM+ASCs enhance bone healing compared to the control on the gingival level. In conclusion, DAM with ASC or without cells and the ECM ensures bone tissue healing. The membrane supported neovascularization and promoted osteoconduction.

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Section: Discussionsupporting

confidence: 61%

Section: Discussionmentioning

confidence: 99%

Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Dziedzic¹,

Mogharbel²,

Irioda³

et al. 2021

Membranes

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show abstract

“…However, this study lacks histological data to support this result. Finally, Sabouri et al proposed a novel approach by mineralizing AM before cell-seeding (Sabouri et al, 2020 ). They stated that the mineralized and seeded AM promoted higher bone regeneration than conventional seeded AM.…”

Section: Resultsmentioning

confidence: 99%

Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review

Etchebarne

Fricain

Kerdjoudj

et al. 2021

Front. Bioeng. Biotechnol.

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Thanks to their biological properties, amniotic membrane (AM), and its derivatives are considered as an attractive reservoir of stem cells and biological scaffolds for bone regenerative medicine. The objective of this systematic review was to assess the benefit of using AM and amniotic membrane-derived products for bone regeneration. An electronic search of the MEDLINE—Pubmed database and the Scopus database was carried out and the selection of articles was performed following PRISMA guidelines. This systematic review included 42 articles taking into consideration the studies in which AM, amniotic-derived epithelial cells (AECs), and amniotic mesenchymal stromal cells (AMSCs) show promising results for bone regeneration in animal models. Moreover, this review also presents some commercialized products derived from AM and discusses their application modalities. Finally, AM therapeutic benefit is highlighted in the reported clinical studies. This study is the first one to systematically review the therapeutic benefits of AM and amniotic membrane-derived products for bone defect healing. The AM is a promising alternative to the commercially available membranes used for guided bone regeneration. Additionally, AECs and AMSCs associated with an appropriate scaffold may also be ideal candidates for tissue engineering strategies applied to bone healing. Here, we summarized these findings and highlighted the relevance of these different products for bone regeneration.

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“…They were shown to effectively deliver bioactive molecules such as cefazolin and moxifloxacin, where the Amnio-M could sustain their release for up to 7 weeks [ 179 , 180 ]. Furthermore, the Amnio-M was loaded with calcium and phosphate using the double diffusion method to develop a mineralized membrane capable of bone regeneration [ 181 ]. It is worth mentioning that Amnio-M was investigated for effectively acting as a carrier for stem cells delivery from different sources (Table 3 ).…”

Section: Essential Considerations For Biomedical Applications Of the Amnio-mmentioning

confidence: 99%

Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

et al. 2022

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The amniotic membrane (Amnio-M) has various applications in regenerative medicine. It acts as a highly biocompatible natural scaffold and as a source of several types of stem cells and potent growth factors. It also serves as an effective nano-reservoir for drug delivery, thanks to its high entrapment properties. Over the past century, the use of the Amnio-M in the clinic has evolved from a simple sheet for topical applications for skin and corneal repair into more advanced forms, such as micronized dehydrated membrane, amniotic cytokine extract, and solubilized powder injections to regenerate muscles, cartilage, and tendons. This review highlights the development of the Amnio-M over the years and the implication of new and emerging nanotechnology to support expanding its use for tissue engineering and clinical applications. Graphical Abstract

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Mineralized Human Amniotic Membrane as a Biomimetic Scaffold for Hard Tissue Engineering Applications

Cited by 14 publications

References 54 publications

Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review

Applications of the amniotic membrane in tissue engineering and regeneration: the hundred-year challenge

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