Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review

Etchebarne, Marion; Fricain, Jean-Christophe; Kerdjoudj, Halima; Pietro, Roberta Di; Wolbank, Susanne; Gindraux, Florelle; Fénelon, Mathilde

doi:10.3389/fbioe.2021.661332

Cited by 18 publications

(17 citation statements)

References 101 publications

(191 reference statements)

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“…We have accumulated considerable evidences on hAM use for bone regeneration from experimental studies ( Gindraux and Obert, 2010 ; Obert et al, 2012 ; Gindraux et al, 2013 ; Laurent et al, 2014 ; Gindraux et al, 2017 ; Laurent R. et al, 2017 ; Fenelon et al, 2018b ; Gindraux et al, 2018 ; Fenelon et al, 2019 ; Gualdi et al, 2019 ; Fenelon et al, 2020 ; Etchebarne et al, 2021 ; Fénelon et al, 2021 ). The diversity of the conditions and methods of membrane application make it difficult to find relevant information in the literature on surgery and tools to judge its efficacy.…”

Section: Introductionmentioning

confidence: 99%

Surgical Application of Human Amniotic Membrane and Amnion-Chorion Membrane in the Oral Cavity and Efficacy Evaluation: Corollary With Ophthalmological and Wound Healing Experiences

Odet

Louvrier

Meyer

et al. 2021

Front. Bioeng. Biotechnol.

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Due to its intrinsic properties, there has been growing interest in human amniotic membrane (hAM) in recent years particularly for the treatment of ocular surface disorders and for wound healing. Herein, we investigate the potential use of hAM and amnion-chorion membrane (ACM) in oral surgery. Based on our analysis of the literature, it appears that their applications are very poorly defined. There are two options: implantation or use as a cover material graft. The oral cavity is submitted to various mechanical and biological stimulations that impair membrane stability and maintenance. Thus, some devices have been combined with the graft to secure its positioning and protect it in this location. This current opinion paper addresses in detail suitable procedures for hAM and ACM utilization in soft and hard tissue reconstruction in the oral cavity. We address their implantation and/or use as a covering, storage format, application side, size and number, multilayer use or folding, suture or use of additional protective covers, re-application and resorption/fate. We gathered evidence on pre- and post-surgical care and evaluation tools. Finally, we integrated ophthalmological and wound healing practices into the collected information. This review aims to help practitioners and researchers better understand the application of hAM and ACM in the oral cavity, a place less easily accessible than ocular or cutaneous surfaces. Additionally, it could be a useful reference in the generation of new ideas for the development of innovative protective covering, suturing or handling devices in this specific indication. Finally, this overview could be considered as a position paper to guide investigators to fulfill all the identified criteria in the future.

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Section: Introductionmentioning

confidence: 99%

Surgical Application of Human Amniotic Membrane and Amnion-Chorion Membrane in the Oral Cavity and Efficacy Evaluation: Corollary With Ophthalmological and Wound Healing Experiences

Odet

Louvrier

Meyer

et al. 2021

Front. Bioeng. Biotechnol.

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“…The amniotic membrane, the innermost layer of the placenta, can be collected after informed ethical consent and without ethical debate since this material is usually discarded. This tissue is immune-privileged, contains immunoregulatory factors [ 21 ], with tissue engineering applications [ 22 ], and has been recognized as an alternative to other commercially available membranes for bone regeneration [ 23 ]. The applications of the amniotic membrane include fresh, cryopreserved, lyophilized, and commercialized products, besides the resulting biomaterial from de-epithelialization and decellularization [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Dziedzic¹,

Mogharbel²,

Irioda³

et al. 2021

Membranes

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Periodontitis is a prevalent disease characterized by the loss of periodontal supporting tissues, bone, periodontal ligament, and cementum. The application of a bone tissue engineering strategy with Decellularized Human Amniotic Membrane (DAM) with adipose-derived stromal cells (ASCs) has shown to be convenient and valuable. This study aims to investigate the treatments of a rat periodontal furcation defect model with DAM, ASCs, and a mineralized extracellular matrix (ECM). Rat ASCs were expanded, cultivated on DAM, and with a bone differentiation medium for four weeks, deposited ECM on DAM. Periodontal healing for four weeks was evaluated by micro-computed tomography and histological analysis after treatments with DAM, ASCs, and ECM and compared to untreated defects on five consecutive horizontal levels, from gingival to apical. The results demonstrate that DAM preserves its structure during cultivation and healing periods, supporting cell attachment, permeation, bone deposition on DAM, and periodontal regeneration. DAM and DAM+ASCs enhance bone healing compared to the control on the gingival level. In conclusion, DAM with ASC or without cells and the ECM ensures bone tissue healing. The membrane supported neovascularization and promoted osteoconduction.

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“…Based on Lindenmair's study (Lindenmair et al, 2010) and Eilbl's patent (Eibl and Redl, 2011), we considered hAM an innovative medication for bone repair. Meanwhile, we have accumulated extensive experience with hAM and perinatal tissues (Gindraux and Obert, 2010;Obert et al, 2012;Gindraux et al, 2013;Laurent et al, 2014a;Laurent et al, 2014b;Gindraux et al, 2017;Laurent et al, 2017;Centurione et al, 2018;Laurent et al, 2018;Bourgeois et al, 2019;Fenelon et al, 2019;Gualdi et al, 2019;Fenelon et al, 2020;Gulameabasse et al, 2020;Passaretta et al, 2020;Silini et al, 2020;Fénelon et al, 2021a;Odet et al, 2021;Fenelon et al, 2021;Etchebarne et al, 2021;Gindraux, 2021;Dubus et al, 2022a;Dubus et al, 2022b). Because the use of hAM in bone repair still requires some adaptations (Fenelon et al, 2021;Etchebarne et al, 2021), we looked for a disease that could benefit from both wound healing and bone repair as endpoints.…”

Section: Introductionmentioning

confidence: 99%

Tips and Tricks and Clinical Outcome of Cryopreserved Human Amniotic Membrane Application for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Pilot Study

Odet

Meyer

Gaudet

et al. 2022

Front. Bioeng. Biotechnol.

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Medication-related osteonecrosis of the jaw (MRONJ) is a complication of certain pharmacological treatments such as bisphosphonates, denosumab, and angiogenesis inhibitors. There are currently no guidelines on its management, particularly in advanced stages. The human amniotic membrane (hAM) has low immunogenicity and exerts anti-inflammatory, antifibrotic, antimicrobial, antiviral, and analgesic effects. It is a source of stem cells and growth factors promoting tissue regeneration. hAM acts as an anatomical barrier with suitable mechanical properties (permeability, stability, elasticity, flexibility, and resorbability) to prevent the proliferation of fibrous tissue and promote early neovascularization at the surgical site. In oral surgery, hAM stimulates healing and facilitates the proliferation and differentiation of epithelial cells in the oral mucosa and therefore its regeneration. We proposed using cryopreserved hAM to eight patients suffering from cancer (11 lesions) with stage 2–3 MRONJ on a compassionate use basis. A collagen sponge was added in some cases to facilitate hAM grafting. One or three hAMs were applied and one patient had a reapplication. Three patients had complete closure of the surgical site with proper epithelialization at 2 weeks, and two of them maintained it until the last follow-up. At 1 week after surgery, three patients had partial wound dehiscence with partial healing 3 months later and two patients had complete wound dehiscence. hAM reapplication led to complete healing. All patients remained asymptomatic with excellent immediate significant pain relief, no infections, and a truly positive impact on the patients’ quality of life. No adverse events occurred. At 6 months of follow-up, 80% of lesions had complete or partial wound healing (30 and 50%, respectively), while 62.5% of patients were in stage 3. Radiological evaluations found that 85.7% of patients had stable bone lesions (n = 5) or new bone formation (n = 1). One patient had a worsening MRONJ but remained asymptomatic. One patient did not attend his follow-up radiological examination. For the first time, this prospective pilot study extensively illustrates both the handling and surgical application of hAM in MRONJ, its possible association with a collagen sponge scaffold, its outcome at the site, the application of multiple hAM patches at the same time, and its reapplication.

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Use of Amniotic Membrane and Its Derived Products for Bone Regeneration: A Systematic Review

Cited by 18 publications

References 101 publications

Surgical Application of Human Amniotic Membrane and Amnion-Chorion Membrane in the Oral Cavity and Efficacy Evaluation: Corollary With Ophthalmological and Wound Healing Experiences

Surgical Application of Human Amniotic Membrane and Amnion-Chorion Membrane in the Oral Cavity and Efficacy Evaluation: Corollary With Ophthalmological and Wound Healing Experiences

Adipose-Derived Stromal Cells and Mineralized Extracellular Matrix Delivery by a Human Decellularized Amniotic Membrane in Periodontal Tissue Engineering

Tips and Tricks and Clinical Outcome of Cryopreserved Human Amniotic Membrane Application for the Management of Medication-Related Osteonecrosis of the Jaw (MRONJ): A Pilot Study

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