Mineralization of bioactive marine sponge and electrophoretic deposition on Ti-6Al-4V implant for osteointegration

Mehnath, Sivaraj; Arjama, Mukherjee; Rajan, Mariappan; Premkumar, Kumpati; Karthikeyan, K.; Jeyaraj, Murugaraj

doi:10.1016/j.surfcoat.2020.125727

Cited by 29 publications

(6 citation statements)

References 72 publications

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“…Drug-eluting porous implants and biodegradable implants that degrade over time and are replaced by healthy body tissue have also attracted considerable interest [ 8 , 9 ]. However, another relatively simple approach leading to successful osseointegration and long-term stability can be achieved by coating implants with bioactive coatings that eliminate implant biological inertness and promote tissue–implant bonding at the interface [ 10 , 11 , 12 , 13 , 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.

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Section: Introductionmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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“…Metal surface modification by applying composite coatings could overcome the problem, enhancing the biocompatibility at the same time. The electrophoretic deposition process (EPD) is a convenient technique that allows obtaining high-purity composite coatings with controlled topography and morphology at room temperature . The production of biocompatible materials including drugs and/or biologically active molecules, maintaining the overall composite safety and nontoxicity for medical use, is the main advantage of the EPD technique.…”

Section: Introductionmentioning

confidence: 99%

“…The electrophoretic deposition process (EPD) is a convenient technique that allows obtaining high-purity composite coatings with controlled topography and morphology at room temperature. 8 The production of biocompatible materials including drugs and/or biologically active molecules, maintaining the overall composite safety and nontoxicity for medical use, is the main advantage of the EPD technique. The capability of processing drugs and therapeutic agents at room temperature singled out EPD as a prospective technique for obtaining biomaterials, especially due to drug sensitivity to high temperatures.…”

Section: Introductionmentioning

confidence: 99%

Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate

et al. 2020

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The electrophoretic deposition process (EPD) was utilized to produce bioactive hydroxyapatite/chitosan (HAP/CS) and hydroxyapatite/chitosan/gentamicin (HAP/CS/Gent) coatings on titanium. The bioactivity of newly synthesized composite coatings was investigated in the simulated body fluid (SBF) and examined by X-ray diffraction, Fourier transform infrared spectroscopy, and field emission scanning electron microscopy. The obtained results revealed carbonate-substituted hydroxyapatite after immersion in SBF, emphasizing the similarity of the biomimetically grown HAP with the naturally occurring apatite in the bone. The formation of biomimetic HAP was confirmed by electrochemical impedance spectroscopy and polarization measurements, through the decrease in corrosion current density and coating capacitance values after 28-day immersion in SBF. The osseointegration ability was further validated by measuring the alkaline phosphatase activity (ALP) indicating the favorable osseopromotive properties of deposited coatings (significant increase in ALP levels for both HAP/CS (3.206 U mL–1) and HAP/CS/Gent (4.039 U mL–1) coatings, compared to the control (0.900 U mL–1)). Drug-release kinetics was investigated in deionized water at 37 °C by high-performance liquid chromatography coupled with mass spectrometry. Release profiles revealed the beneficial “burst-release effect” (∼21% of gentamicin released in the first 48 h) as a potentially promising solution against the biofilm formation in the initial period. When tested against human and mice fibroblast cells (MRC-5 and L929), both composite coatings showed a noncytotoxic effect (viability >85%), providing a promising basis for further medical application trials.

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“…Electrophoretic statement (EPD) is an adaptable and least expensive method for the deposition of the metallic substrate through pulse current deposition. The EPD deposition, the continuous, homogenous layer with uniform grain size and the complete coating, was obtained, and it has improved mechanical and substance properties (Sumathra et al, 2018 ; Mehnath et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

In-vivo Investigations of Hydroxyapatite/Co-polymeric Composites Coated Titanium Plate for Bone Regeneration

Diwu¹,

Dong

Nasif

et al. 2021

Front. Cell Dev. Biol.

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A perfect mimic of human bone is very difficult. Still, the latest advancement in biomaterials makes it possible to design composite materials with morphologies merely the same as that of bone tissues. In the present work is the fabrication of selenium substituted Hydroxyapatite (HAP-Se) covered by lactic acid (LA)—Polyethylene glycol (PEG)—Aspartic acid (AS) composite with the loading of vincristine sulfate (VCR) drug (HAP-Se/LA-PEG-AS/VCR) for twin purposes of bone regenerations. The HAP-Se/LA-PEG-AS/VCR composite coated on titanium implant through electrophoretic deposition (EPD). The prepared composite characterized using FTIR, XRD techniques to rely on the composites' chemical nature and crystalline status. The morphology of the composite and the titanium plate with the composite coating was investigated by utilizing SEM, TEM instrument techniques, and it reveals the composite has porous morphology. The drug (VCR) load in HAP-Se/LA-PEG-AS and releasing nature were investigated through UV-Visible spectroscopy at the wavelength of 295 nm. In vitro study of SBF treatment shows excellent biocompatibility to form the HAP crystals. The viability against MG63 and toxicity against Saos- 2 cells have expressed the more exceptional biocompatibility in bone cells and toxicity with the cancer cells of prepared composites. The in-vivo study emphasizes prepared biomaterial suitable for implantation and helps accelerate bone regeneration on osteoporosis and osteosarcoma affected hard tissue.

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Mineralization of bioactive marine sponge and electrophoretic deposition on Ti-6Al-4V implant for osteointegration

Cited by 29 publications

References 72 publications

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Assessing the Bioactivity of Gentamicin-Preloaded Hydroxyapatite/Chitosan Composite Coating on Titanium Substrate

In-vivo Investigations of Hydroxyapatite/Co-polymeric Composites Coated Titanium Plate for Bone Regeneration

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