Mineral and vitamins consumption is associated with longer telomeres among US adults

Mazidi, Mohsen; Kengne, André Pascal; Banach, Maciej

doi:10.20452/pamw.3927

Cited by 34 publications

(24 citation statements)

References 13 publications

(21 reference statements)

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“…A recent study in Japan also reported a positive association between buccal TL and daily intake of antioxidant vitamins including lycopene, phenolics, favonoids, resveratrol, phloridzin, and pectin [ 22 ]. In the same line, we have recently reported that participants with higher intake of mineral and vitamin consumption have longer TL [ 23 ]. In most Western countries, including US and Canada, fresh fruits and vegetables as the indicators of quality food are not accessible to low-income families [ 24 – 26 ].…”

Section: Discussionmentioning

confidence: 65%

Food Security and Leukocyte Telomere Length in Adult Americans

Mazidi

Kengne

Vatanparast

2017

Oxidative Medicine and Cellular Longevity

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Background and Purpose Leukocyte telomere length (LTL) is a biomarker of biologic age. Whether food security status modulates LTL is still unknown. We investigated the association between food security and LTL in participants of the 1999–2002 US National Health and Nutrition Examination Survey (NHANES). Methods Analysis of covariance (ANCOVA) was used to evaluate the association between food security categories and LTL controlling for sex, race, and education and accounting for the survey design and sample weights. Results We included 10,888 participants with 5228 (48.0%) being men. They were aged on average 44.1 years. In all, 2362 (21.7%) had less than high school, 2787 (25.6%) had achieved high school, while 5705 (52.5%) had done more than high school. In sex-, race-, and education-adjusted ANCOVA, average LTL (T/S ratio) for participants with high food security versus those with marginal, low, or very low food security was 1.32 versus 1.20 for the age group 25–35 years and 1.26 versus 1.11 for the 35–45 years, (p < 0.001). Conclusion The association between food insecurity and LTL shortening in young adults suggest that some of the future effects of food insecurity on chronic disease risk in this population could be mediated by telomere shortening.

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Section: Discussionmentioning

confidence: 65%

Food Security and Leukocyte Telomere Length in Adult Americans

Mazidi

Kengne

Vatanparast

2017

Oxidative Medicine and Cellular Longevity

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“…Furthermore, it has been reported that LA intake was inversely associated with leukocyte telomere length (LTL) in female participants of the Nurses’ Health Study [ 43 ]. As an indicator of oxidative stress, DNA damage and cellular senescence, LTL has been postulated as a biomarker of aging and age-related chronic diseases, including CAD and T2DM [ 43 , 44 ].…”

Section: Discussionmentioning

confidence: 99%

Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease

Poręba

Rostoff

Siniarski

et al. 2018

Cardiovasc Diabetol

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BackgroundThere are inconsistent data about the role of serum phospholipid fatty acid composition in patients with type 2 diabetes (T2DM) and atherosclerotic cardiovascular disease (ASCVD). The aim of the study was to investigate the relationship between serum phospholipid fatty acid composition, systemic low-grade inflammation, and glycemic control in high-risk T2DM patients.MethodsSeventy-four patients (26% women, mean age 65.6 ± 6.8 years) with T2DM (median diabetes duration 10 years) and documented ASCVD (74 with coronary artery disease, 26 with peripheral arterial disease) were enrolled in the study. Baseline HbA1c was estimated using turbidimetric inhibition immunoassay. According to the median value of HbA1c the patients were grouped into those with HbA1c < 7.0% (< 53 mmol/mol) (n = 38) and those with HbA1c ≥ 7.0% (≥ 53 mmol/mol) (n = 36). Serum phospholipid fatty acids were measured with gas chromatography.ResultsPatients with HbA1c ≥ 7.0%, compared with those with HbA1c < 7.0% had similar composition of saturated and monounsaturated fatty acids in serum phospholipids, but had higher concentrations of linoleic acid (LA) and higher n-6/n-3 polyunsaturated fatty acid (PUFA) ratio as well as lower levels of eicosapentaenoic acid (EPA), total n-3 PUFAs, and the EPA/arachidonic acid ratio. We found that LA (r = 0.25; p = 0.03) and n-6/n-3 PUFA ratio (r = 0.28; p = 0.02) were positively correlated with HbA1c. Multivariate logistic regression analysis showed that n-6/n-3 PUFA ratio, hsCRP and T2DM duration were independent predictors of worse glycemic control in patients with T2DM and ASCVD.ConclusionsThis study showed that glycemic control in high-risk T2DM patients with ASCVD was significantly associated with unfavorable serum phospholipid n-6/n-3 PUFA ratio and greater systemic inflammation.

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“…The NHANES uses a multistage probability sampling strategy, which oversamples certain subgroups of the population, including blacks, Mexican-Americans, and those of lower socioeconomic status [2, 13, 14, 16]. The National Center for Health Statistics Research Ethics Review Board approved the NHANES protocol, and consent was obtained from all participants (informed consent was obtained from all subjects) [2, 13, 17]. Moreover, all methods were performed in accordance with the relevant guidelines and regulations [2, 13, 14].…”

Section: Methodsmentioning

confidence: 99%

“…The Centers for Diseases Control (CDC) conducted a quality control review before linking the TL data to the NHANES data files. The CDC Institutional Review Board granted human subject approval for this study [2, 17]. …”

Section: Methodsmentioning

confidence: 99%

Association between telomere length and complete blood count in US adults

Mazidi¹,

Penson²,

Banach³

2017

aoms

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IntroductionTelomere length (TL) is related to age-related health outcomes, but little is known about the relationship between TL and complete blood count (CBC) parameters. We aimed to determine the relationship between TL and CBC in a sample of healthy US adults.Material and methodsParticipants in the National Health and Nutrition Examination Survey (NHANES) recruited between 1999 and 2002 who had essential data on total CBC and TL were studied. We computed age- and race-adjusted mean values for total CBC using analysis of covariance (ANCOVA). All statistical analyses accounted for the survey design and sample weights by using SPSS Complex Samples v22.0 (IBM Corp, Armonk, NY).ResultsOf the 8892 eligible participants, 47.8% (n = 4123) were men. The mean age was 41.8 years overall, 41.0 years in men and 42.6 in women (p = 0.238). The sex-stratified ANCOVA showed no significant difference in the total CBC across TL quartiles (all p > 0.05) in both sexes. In the adjusted model, there was a significant negative relationship with monocyte count (β = –0.051, 95% CI: –0.422; –0.142), mean cell hemoglobin (β = –0.051, 95% CI: –0.038; –0.011) and red cell distribution width (β = –0.031, 95% CI: –0.054; –0.003), while there was a significant positive relationship with basophil ratio (β = 0.046, 95% CI: 0.049–0.171).ConclusionsThese results support the possibility that telomere attrition may be a marker for reduced proliferative reserve in hematopoietic progenitor cells.

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Mineral and vitamins consumption is associated with longer telomeres among US adults

Cited by 34 publications

References 13 publications

Food Security and Leukocyte Telomere Length in Adult Americans

Food Security and Leukocyte Telomere Length in Adult Americans

Relationship between polyunsaturated fatty acid composition in serum phospholipids, systemic low-grade inflammation, and glycemic control in patients with type 2 diabetes and atherosclerotic cardiovascular disease

Association between telomere length and complete blood count in US adults

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