Food Security and Leukocyte Telomere Length in Adult Americans

Mazidi, Mohsen; Kengne, André Pascal; Vatanparast, Hassan

doi:10.1155/2017/5427657

Cited by 11 publications

(8 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Food insecurity, which is defined as an individual or household having an insufficient supply or access to safe and nutritious food needed for normal growth and to maintain a healthy life (16) , is linked to higher stress and is considered a chronic stressor (17–19) . In line with findings from other socioeconomic factors, food insecurity was recently found to be negatively associated with TL in a US representative sample (20) .…”

supporting

confidence: 85%

Food Insecurity, telomere length and the potential modifying effects of social support in National Health and Nutrition Examination Survey

Lima,

Ren,

et al. 2023

Public Health Nutr.

View full text Add to dashboard Cite

Objective: Telomere length (TL) is a posited pathway through which chronic stress results in biological dysregulation and subsequent adverse health outcomes. Food insecurity is associated with shorter TL. Social support, which is defined by the size and function of an individual’s social network, is associated with better health outcomes. The present study assesses whether social support modifies the relationship between food security and TL. Design: Cross-sectional study design. Linear regression was used to assess the association between social support and TL, stratified by social support level. A multiplicative interacted model was used to formally test modification. Setting: Data come from the National Health and Nutrition Examination Survey (NHANES) 1999-2000 and 2001-2002 waves. Participants: Adults aged 60 years and older who have measurements for TL. Results: Our sample comprised 2,674 participants, and 63.5% of the total sample had low social support, with 13.3% being food insecure. In fully adjusted models, food insecurity was negatively though modestly associated (P=0.13) with TL. Associations between food insecurity and TL were significantly modified by social support (interaction P=0.026), whereby food insecurity had a stronger effect among individuals with high social support (coefficient = -0.099 (95% CI: -0.161, -0.038)) compared to low social support (coefficient = -0.001, (95% CI: -0.033, 0.032)). Conclusion: Food insecurity is modestly associated with shorter TL. Contrary to our hypothesis, food insecurity had more deleterious effects on TL among participants with high social support than low social support. Results may indicate that the food insecure population is a higher needs population, and increased social support reflects these needs rather than providing protective effects.

show abstract

supporting

confidence: 85%

Food Insecurity, telomere length and the potential modifying effects of social support in National Health and Nutrition Examination Survey

Lima,

Ren,

et al. 2023

Public Health Nutr.

View full text Add to dashboard Cite

show abstract

“…low, medium, and high molecular weight forms) that might exert different functions [98][99][100]. The guanine residues of telomeric DNA sequences are susceptible to oxidative stress [101]. When DNA double-strand breaks at telomeric regions is promoted, the distal fragment is lost, and therefore telomeres shorten [102].…”

Section: Discussionmentioning

confidence: 99%

Serum anti-inflammatory and inflammatory markers have no causal impact on telomere length: a Mendelian randomization study

et al. 2021

Self Cite

View full text Add to dashboard Cite

IntroductionThe relationship between inflammatory and anti-inflammato�ry markers and telomere length (TL), a biological index of aging, is still poor�ly understood. By applying a 2-sample Mendelian randomization (MR), we investigated the causal associations between adiponectin, bilirubin, C-reac�tive protein (CRP), leptin, and serum uric acid (SUA) with TL.Material and methodsMR was implemented by using summary-level data from the largest ever genome-wide association studies (GWAS) conducted on our interested exposure and TL. Inverse variance weighted method (IVW), weighted median (WM)-based method, MR-Egger, MR-Robust Adjusted Pro�file Score (RAPS), and MR-Pleiotropy RESidual Sum and Outlier (PRESSO) were applied. Sensitivity analysis was conducted using the leave-one-out method.ResultsWith regard to adiponectin, CRP, leptin, and SUA levels, we found no effect on TL for all 4 types of tests (all p > 0.108). Results of the MR-Egger (p = 0.892) and IVW (p = 0.124) showed that bilirubin had no effect on telomere maintenance, whereas the results of the WM (p = 0.030) and RAPS (p = 0.022) were negative, with higher bilirubin concentrations linked to shorter TL. There was a low likelihood of heterogeneity for all the estima�tions, except for bilirubin (IVW p = 0.026, MR Egger p = 0.018). MR-PRESSO highlighted no outlier. For all the estimations, we observed negligible inter�cepts that were indicative of low likelihood of the pleiotropy (all p > 0.161). The results of leave-one-out method demonstrated that the links are not driven because of single nucleotide polymorphisms (SNPs).ConclusionsOur results highlight that neither the anti-inflammatory nor pro-inflammatory markers tested have any significant causal effect on TL. The casual role of bilirubin on TL still needs to be investigated.

show abstract

“…Food insecurity, as a social determinant of health, is another marker of socioeconomic distress that has been associated with CVD risk factors and other outcomes in recent years 18 – 21 . However, the underlying mechanism is not yet known.…”

Section: Introductionmentioning

confidence: 99%

Serum trans-fatty acids level are positively associated with lower food security among american adults

Mazidi

Vatanparast

2018

Nutr & Diabetes

Self Cite

View full text Add to dashboard Cite

ObjectivesIn the current study we aimed to assess whether the food security is associated with serum trans-fatty acids (TFAs) and dietary fat.MethodsAnalyses were restricted to participants (from the US National Health and Nutrition Examination Survey) with data available on serum and diet TFAs and food security status from 2009 to 2010. All statistical analyses (analysis of covariance and linear regression) accounted for the survey design and sample weights.ResultsWe included 3876 participants, overall (48.6%) participants were men, and (51.4%) were women, generally (69.0%) had high food security. Subjects with higher food security had a higher level of education as well (p < 0.001). Age-adjusted, sex-adjusted, race-adjusted, education-adjusted mean of trans 9-octadecenoic acid and trans-9, trans-12-octadecadienoic acid were higher in plasma of participants with lower food security (all p < 0.001), moreover in same model there was a significant positive association between plasma level of trans-11-octadecenoic acid, trans-9-octadecenoic acid and trans-9, trans-12-octadecadienoic acid and score of food security. Further, age, sex, race, education, and energy intake adjusted mean of dietary fatty acids show that total polyunsaturated fatty acids are higher in subjects with higher food security (p = 0.026) while, cholesterol consumption is higher in subjects with lower food security (p = 0.039).ConclusionsOur findings provide more evidence on the association between food insecurity and the higher level of TFAs in serum and different type of fat in the diet.

show abstract

Food Security and Leukocyte Telomere Length in Adult Americans

Cited by 11 publications

References 27 publications

Food Insecurity, telomere length and the potential modifying effects of social support in National Health and Nutrition Examination Survey

Food Insecurity, telomere length and the potential modifying effects of social support in National Health and Nutrition Examination Survey

Serum anti-inflammatory and inflammatory markers have no causal impact on telomere length: a Mendelian randomization study

Serum trans-fatty acids level are positively associated with lower food security among american adults

Contact Info

Product

Resources

About