Association between telomere length and complete blood count in US adults

Mazidi, Mohsen; Penson, Peter E.; Banach, Maciej

doi:10.5114/aoms.2017.67281

Cited by 30 publications

(28 citation statements)

References 29 publications

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“…LTL was measured from purified DNA isolated from whole blood, using the Puregene (D-50 K) kit protocol (Gentra Systems, Inc., Minneapolis, Minnesota). The quantitative polymerase chain reaction method was then used to measure LTL relative to standard reference DNA [also known as the telomere-to-single copy gene (T/S) ratio] [ 13 – 15 ]. A validated questionnaire developed by the US Department of Agriculture (USDA) was used to assess income-related household food security over the prior 12 months [ 16 ].…”

Section: Methodsmentioning

confidence: 99%

Food Security and Leukocyte Telomere Length in Adult Americans

Mazidi

Kengne

Vatanparast

2017

Oxidative Medicine and Cellular Longevity

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Background and Purpose Leukocyte telomere length (LTL) is a biomarker of biologic age. Whether food security status modulates LTL is still unknown. We investigated the association between food security and LTL in participants of the 1999–2002 US National Health and Nutrition Examination Survey (NHANES). Methods Analysis of covariance (ANCOVA) was used to evaluate the association between food security categories and LTL controlling for sex, race, and education and accounting for the survey design and sample weights. Results We included 10,888 participants with 5228 (48.0%) being men. They were aged on average 44.1 years. In all, 2362 (21.7%) had less than high school, 2787 (25.6%) had achieved high school, while 5705 (52.5%) had done more than high school. In sex-, race-, and education-adjusted ANCOVA, average LTL (T/S ratio) for participants with high food security versus those with marginal, low, or very low food security was 1.32 versus 1.20 for the age group 25–35 years and 1.26 versus 1.11 for the 35–45 years, (p < 0.001). Conclusion The association between food insecurity and LTL shortening in young adults suggest that some of the future effects of food insecurity on chronic disease risk in this population could be mediated by telomere shortening.

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Section: Methodsmentioning

confidence: 99%

Food Security and Leukocyte Telomere Length in Adult Americans

Mazidi

Kengne

Vatanparast

2017

Oxidative Medicine and Cellular Longevity

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“…Accumulating evidence has shown a high prevalence of masked hypertension in both treated and untreated hypertensive patients [11][12][13][14]. However, cardiovascular risk of masked hypertension is unclear and needs further elucidation.…”

Section: Introductionmentioning

confidence: 99%

Association of masked uncontrolled hypertension and cardiovascular diseases in treated hypertensive patients

Shi

Zhang

Wang

et al. 2020

aoms

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The aim of the study was to evaluate the association of masked uncontrolled hypertension (MUCH) and prevalence of cardiovascular disease in treated hypertensive patients. Material and methods: Patients' demographics and prior medical histories were collected. Fasting venous blood was drawn for evaluation of serum creatinine level, which was used to calculate glomerular filtration rate (GFR). Clinic blood pressure (BP) and 24 h ambulatory blood pressure monitoring (ABPM) measurements were performed. Based on the clinic BP and 24 h ABPM results, patients were divided into MUCH and non-masked hypertension groups. Results: Compared to patients without masked hypertension, MUCH patients were older (62.4 ±11.2 vs. 59.7 ±10.4 years, p < 0.05), more likely to be male (66.9% vs. 63.4%), had diabetes (33.9% vs. 29.6%), longer hypertension duration (12.4 ±5.3 vs. 9.5 ±4.5 years, p < 0.05), lower GFR (79.5 ±11.6 vs. 82.4 ±10.3 ml/min/1.73 m 2 , p < 0.05), treated with b-blocker (39.0% vs. 32.7%, p < 0.05) and required more antihypertensive medications (2.7 ±0.5 vs. 2.2 ±0.3, p < 0.05). MUCH patients have higher cardiovascular disease prevalence than that without masked hypertension (30.1% vs. 23.4%, p < 0.05). After adjustment for covariates, MUCH was still independently associated with higher cardiovascular disease prevalence with odds ratio 1.38 (95% confidence interval 1.17-1.62, p < 0.05). Conclusions: The MUCH is independently associated with prevalent cardiovascular disease in treated hypertensive patients. Future studies are needed to evaluate whether correction of MUCH can improve patients' outcomes.

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“…The NCHS Research Ethics Review Board approved the NHANES protocol and consent was obtained from all participants [18, 19]. Details on the demographic, socioeconomic, dietary, and health-related characteristics of participants were collected by trained interviewers, using questionnaires administered during home visits [20].…”

Section: Methodsmentioning

confidence: 99%

Inflammatory Markers Are Positively Associated with Serumtrans-Fatty Acids in an Adult American Population

Mazidi

Gao

Kengne

2017

Journal of Nutrition and Metabolism

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Background and Aim The relationship between serum trans-fatty acids (TFAs) and systemic inflammation markers is unclear. We investigated the association of serum TFAs with high sensitivity C-reactive protein (hs-CRP) and fibrinogen in adult Americans. Methods The 1999 to 2000 National Health and Nutrition Examination Survey (NHANES) participants with measured data on hs-CRP and fibrinogen were included. TFAs were measured via capillary gas chromatography and mass spectrometry using negative chemical ionization. Analysis of covariance and multivariable-adjusted linear regression models were used to investigate the associations between these parameters, accounting for the survey design. Results Of the 5446 eligible participants, 46.8% (n = 2550) were men. The mean age was 47.1 years overall: 47.8 years in men and 46.5 years in women (p = 0.085). After adjustment for age and sex, mean serum TFAs rose with the increasing quarters of hs-CRP and fibrinogen (both p < 0.001). In linear regression models adjusted for age, sex, race, education, marital status, body mass index, and smoking, serum TFAs were an independent predictor of plasma hs-CRP and fibrinogen levels. Conclusion A high level of TFAs appears to be a contributor to an unfavourable inflammatory profile. Because serum TFAs concentrations are affected by dietary TFA intake, these data suggest a possible contribution of TFAs intake modulation in the prevention of inflammation-related chronic diseases.

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Association between telomere length and complete blood count in US adults

Cited by 30 publications

References 29 publications

Food Security and Leukocyte Telomere Length in Adult Americans

Food Security and Leukocyte Telomere Length in Adult Americans

Association of masked uncontrolled hypertension and cardiovascular diseases in treated hypertensive patients

Inflammatory Markers Are Positively Associated with Serumtrans-Fatty Acids in an Adult American Population

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