MIND diet associated with later onset of Parkinson’s disease

Abstract

Background: The MIND diet has been linked with prevention of cognitive decline but has not been fully assessed in the context of Parkinson's disease (PD). Objective: To determine whether MIND diet adherence is associated with the age of Parkinson's disease onset. Methods: Food Frequency Questionnaires from 181 participants with PD were scored for MIND adherence and correlated with age of onset using univariate and multivariate linear models. Results: MIND adherence scores positively correlated with age of onset both independently (p=9.7e-5) and in models including education, sex, disease duration, caloric intake, smoking, and exercise. Differences in age of PD onset in the high vs the low adhering tertiles corresponded to 6 years for men and 10.2 years for women. Effect sizes exceeded those previously reported for the Mediterranean diet. Conclusions: These preliminary data suggest that the MIND diet may be an effective PD-delaying intervention, especially in women.

“Let Food Be Thy Medicine”: Gluten and Potential Role in Neurodegeneration

“…Since adhering to GFD is a tough ally [ 54 , 119 ], several alternative ways to decrease gluten-brain exposure might be envisioned. GF-Mediterranean diet [ 120 ], might be very rewarding as Mediterranean diet adherence significantly correlated with 8.4 years of later onset of PD [ 121 ]. The dysbiosis in CD and the gluten degrading microbial enzyme (glutenase) capacity might suggest probiotic and lactobacilli enhancing prebiotic therapies [ 122 ].…”

Parkinson's Disease: Risk Factor Modification and Prevention

“…120 A recent cross-sectional study showed a correlation between adherences with the MIND or Mediterranean-style diet with later age of PD onset in a Canadian PD cohort—prospective studies are needed to further investigate a possible influence of this diet on PD risk. 121…”

In vitro study of the blood–brain barrier transport of bioactives from Mediterranean foods

“…5,6 In this regard, the Mediterranean diet (MD) has been proposed as a healthy dietary pattern with increasing evidence supporting its beneficial effects towards age-related pathologies, including neurodegenerative disorders and cognitive dysfunctions like AD and PD. [7][8][9] This potential of MD has been mainly related to its high content in plant foods such as fruits, vegetables, and olive oil, which are sources of an array of bioactive compounds. [10][11][12] Hydroxytyrosol (HT) and tyrosol (TYRS) are the major phenolic compounds present in virgin olive oil (VOO) (0.39-41 mg kg −1 and 0.2-32.9 mg kg −1 , respectively), and table olives (14.5-3833 mg kg −1 and 0.435-353.5 mg kg −1 , respectively).…”