Milk Supplementation and Bone Health in Young Adult Chinese Women

Woo, Jean; Lau, Wing-Cheong; Xu, Li; Lam, Christopher Wai Kei; Zhao, Xiaoqun; Yu, Wei; Xing, Xiaoping; Lau, Edith M. C.; Kuhn-Sherlock, B.; Pocock, Nicholas; Eastell, Richard

doi:10.1089/jwh.2006.0222

Cited by 26 publications

(19 citation statements)

References 19 publications

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“…15 Habitual mean calcium intake of less than 500 mg/day was below the recommended intake of 1000 mg for Chinese women. 4,16 An intake of sufficient calcium is essential to maintain metabolic functions together with bone turnover. Low calcium intake combined with a decrease in calcium absorption with ageing could contribute to an increase in fracture risk for older Chinese women.…”

Section: Discussionmentioning

confidence: 99%

“…6 Milk supplementation was also of benefit in young Chinese women and girls, increasing the bone mass over 6 months and 2 years, with some effect on markers of bone resorption. 4,10 These fortified milks also contained vitamin D ranging from 5 to 10 mg/day, which resulted in improved vitamin D status in all four studies.…”

Section: Introductionmentioning

confidence: 96%

“…2 Dairy consumption in Chinese populations is low but milk is potentially of benefit for bone health. 4 The recommended minimum daily requirement for calcium in Chinese women is set at 1000 mg/day 5 but several studies report intakes as low as 230-724 mg/day 1,6,7 and higher dietary calcium intake was associated with higher bone mass. 7 A study in Chinese women living in Hong Kong showed that bone loss can be reduced by supplementing with 800 mg calcium per day using fortified milk.…”

Section: Introductionmentioning

confidence: 99%

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High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

Kruger

Todd

et al. 2012

Eur J Clin Nutr

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BACKGROUND/OBJECTIVES: Risk for developing osteoporosis increases in Asia. The purpose of the study was to evaluate the impact of a high-calcium vitamin D fortified milk (HCM) intervention on parathyroid hormone (PTH) levels, vitamin D status and markers of bone turnover in postmenopausal Chinese women. SUBJECTS/METHODS: Sixty three women (455 years) were assigned to receive two servings of either a calcium/vitamin D fortified milk or a control drink for 12 weeks. PTH, serum 25 (OH)D levels, C-telopeptide of type I collagen (CTX) levels and procollagen type I N-terminal propeptide (PINP) were measured at baseline, 2, 8 and 12 weeks of supplementation. RESULTS: Daily calcium intake at baseline ranged between 260 and 482 mg for the HCM, and 252 and 692 mg for the control group. HCM improved serum 25 (OH)D levels significantly (33.13-39.49 nmol/l), while remaining similar in the control group (29.27-28.21 nmol/l). The difference between the groups were significant at week 2, 8 and 12. The percentage change in PTH levels in the HCM group was significant from week 2 onwards compared to the control drink (Po0.017, Po0.05 and Po0.001 at weeks 2, 8 and 12, respectively). Plasma CTX of the HCM group reduced by 25% between weeks 0 and 2, remaining significantly lower and at similar levels up to week 12. The difference between the HCM and control group for PINP reached significance at weeks 8 (P ¼ 0.011) and 12 (P ¼ 0.003). CONCLUSIONS: The HCM intervention significantly improved vitamin D status and reduced bone turnover over 12 weeks in postmenopausal Chinese women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

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High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

Kruger

Todd

et al. 2012

Eur J Clin Nutr

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“…Healthy Chinese volunteers aged between 20 and 35 years were recruited between February and June 2002 through poster advertisements in public places and mass emailing as previously described [30]. An initial interview excluded women who had a medical history of metabolic bone, liver, endocrine, connective tissue, and respiratory diseases, cancer or previous operations or who were taking calcium or vitamin D supplements or medications (other than oral contraceptives) likely to affect bone metabolism.…”

Section: Participant Recruitmentmentioning

confidence: 99%

Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women

Bacon

Woo

Lau³

et al. 2010

Osteoporos Int

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“…On the other hand, Woo et al [13] studied Chinese women aged 20 -35 years who consumed powdered milk (daily calcium intake equal to 1000 mg) for two years and found little difference in various factors compared with control subjects except significantly higher BMD at the spinal region. They attributed the non-consistent results to age-related differences in bone metabolism and to a lack of compliance.…”

Section: Discussionmentioning

confidence: 99%

The effect of milk consumption on bone mass density in obese and thin adult women

Habibzadeh

2010

Biomedical Human Kinetics

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SummaryStudy aim: To assess the effect of milk consumption lasting two months on BMD of obese and thin young women. Material and methods: A group of 38 untrained women (18 obese [O] -BMI>30, and 20 thin [T] -BMI<20), aged 20 -25, years participated in the study. They were randomly assigned into BMI-matched experimental [E] or control [C] groups containing 9 obese and 10 thin subjects each. Experimental groups were given 2 glasses of milk (600 mg/day of calcium; fat content 1.5%) for 2 months, 3 days a week. At the beginning (Pre) and at the end (Post) of the study, bone mass density (BMD) at the hip and spine (L 2 -L 4 ) was measured using DEXA technique, and oestrogens, calcium and phosphorus were determined in serum. Body fat content (%F) and lean body mass (LBM) were determined using the bioimpedance (BIA) technique. Results: In both experimental groups BMD significantly (p<0.05 -0.001) increased in both areas by 4 -7%. In the TE group, %F significantly (p<0.05) decreased by 8% and LBM significantly (p<0.001) increased by 3%. Serum calcium decreased in all groups except OC by 3 -5% (p<0.05 -0.01) and oestrogens markedly increased in all groups except TC. Conclusion: The data suggest that adequate milk intake (thus calcium) in adolescence is an indicator of attaining adequate bone mass density, thus preventing the risk of osteoporosis.

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Milk Supplementation and Bone Health in Young Adult Chinese Women

Abstract: Age-related bone metabolism and lack of compliance most likely explain the lack of consistent changes in BMD or bone biochemical measures in response to milk supplementation for 2 years in Chinese women aged 20-35 years.

Cited by 26 publications

References 19 publications

High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

High-calcium, vitamin D fortified milk is effective in improving bone turnover markers and vitamin D status in healthy postmenopausal Chinese women

Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women

The effect of milk consumption on bone mass density in obese and thin adult women

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