Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women

Bacon, Catherine J.; Woo, Jean; Lau, Edith M. C.; Lam, C. W. K.; Gamble, Gregory D.; Reid, Ian R.

doi:10.1007/s00198-009-1163-z

Cited by 16 publications

(11 citation statements)

References 44 publications

(60 reference statements)

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“…In Chinese premenopausal women, a serum vitamin D level of 40 nmol/l was found to be the optimum level to “suppress” PTH. 25 In an older study by Lips et al, 26 a level of 30 nmol/l was enough to suppress PTH level in elderly subjects. Interestingly, in Finnish adolescent girls, it was observed also that at levels of 40 nmol/l or above, PTH would start to be suppressed.…”

Section: Discussionmentioning

confidence: 94%

Vitamin D deficiency and biochemical variations among urban Saudi adolescent girls according to season

Sulimani

Mohammed

Alfadda

et al. 2016

SMJ

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Objectives:To determine seasonal variations in the vitamin D status of Saudi adolescent girls in Riyadh, Kingdom of Saudi Arabia (KSA) and its effect in biochemical and clinical characteristics.Methods:In this prospective study, a total of 2000 Saudi females aged 12-18 years from different schools in Riyadh, KSA participated and submitted a generalized questionnaire with clinical information. Fasting blood samples were obtained in 1618 subjects for the winter season (December to February) and only 499 subjects returned to submit fasting blood samples for the summer season (June-August). Circulating serum 25(OH)D, parathyroid hormone (PTH), and other biomarkers of bone remodeling were measured during both seasons.Results:Vitamin D deficiency (serum 25(OH)D <25 nmol/L) was significantly higher during summer than winter (63.5% versus 40.8%; p<0.001). Mean serum PTH was also significantly higher during summer than winter (p<0.01). In all subjects, serum PTH showed a significant inverse association with 25(OH)D at levels below 40 nmol/L (r=-0.21; p<0.001). The prevalence of subjects having clinical and metabolic manifestations suggestive of osteomalacia was 2.1% (N=33 out of 1548).Conclusion:Seasonal variations in the vitamin D status of Saudi adolescent females significantly modifies biochemical parameters as response to vitamin D status change. In the meantime, heightened public health awareness should be given to populations at higher risk for vitamin D deficiency.

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Section: Discussionmentioning

confidence: 94%

Vitamin D deficiency and biochemical variations among urban Saudi adolescent girls according to season

Sulimani

Mohammed

Alfadda

et al. 2016

SMJ

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“…80,81 Obesity, however, is associated with lower levels of 25-OHD and a reduced dose response to oral vitamin D or UV radiation. 7,12 As it may take up to 2-5 months for serum levels of 25-OHD to plateau, 80,82 retesting should not take place before 3 months. There appears to be little difference in 25-OHD values whether the total amount of vitamin D is given as a daily, weekly or monthly dose, with no clear indication that one dosing schedule is more effective than another.…”

Section: Serum 25-ohd Status and Target Valuesmentioning

confidence: 99%

“…Obesity, however, is associated with lower levels of 25‐OHD and a reduced dose response to oral vitamin D or UV radiation 7 , 12 . As it may take up to 2–5 months for serum levels of 25‐OHD to plateau, 80 , 82 retesting should not take place before 3 months.…”

Section: Supplemental Vitamin D Doses Required To Achieve Targetsmentioning

confidence: 99%

Vitamin D and health in adults in Australia and New Zealand: a position statement

Nowson¹,

McGrath

Ebeling

et al. 2012

Medical Journal of Australia

273

258

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The prevalence of vitamin D deficiency varies, with the groups at greatest risk including housebound, community-dwelling older and/or disabled people, those in residential care, dark-skinned people (particularly those modestly dressed), and other people who regularly avoid sun exposure or work indoors. Most adults are unlikely to obtain more than 5%-10% of their vitamin D requirement from dietary sources. The main source of vitamin D for people residing in Australia and New Zealand is exposure to sunlight. A serum 25-hydroxyvitamin D (25-OHD) level of ≥ 50 nmol/L at the end of winter (10-20 nmol/L higher at the end of summer, to allow for seasonal decrease) is required for optimal musculoskeletal health. Although it is likely that higher serum 25-OHD levels play a role in the prevention of some disease states, there is insufficient evidence from randomised controlled trials to recommend higher targets. For moderately fair-skinned people, a walk with arms exposed for 6-7 minutes mid morning or mid afternoon in summer, and with as much bare skin exposed as feasible for 7-40 minutes (depending on latitude) at noon in winter, on most days, is likely to be helpful in maintaining adequate vitamin D levels in the body. When sun exposure is minimal, vitamin D intake from dietary sources and supplementation of at least 600 IU (15 µg) per day for people aged ≤ 70 years and 800 IU (20 µg) per day for those aged > 70 years is recommended. People in high-risk groups may require higher doses. There is good evidence that vitamin D plus calcium supplementation effectively reduces fractures and falls in older men and women.

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“…While vitamin D supplementation is needed to achieve a desired threshold of serum 25(OH)D concentrations among deficient individuals, there is no universally accepted threshold at which initiating vitamin D supplementation would achieve the greatest impact. In Victoria, Australia for those whose serum levels are 50 nmol/L and below recommendations are to supplement with higher dose 50000 IU per month and serum 25(OH)D to be rechecked after 3 months and then at 12 months [ 6 ] as it takes 3–5 months for serum 25(OH)D to plateau [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Efficacy of high dose Vitamin D supplementation in improving serum 25(OH)D among migrant and non migrant population: a retrospective study

Gowda

Ruwanpathirana

Fong³

et al. 2016

BMC Health Serv Res

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BackgroundHigher dose of vitamin D supplementation 50000 IU is required for those whose serum 25(OH)D levels are 50 nmol/L and below. The increment in serum 25(OH)D though not significantly affected by race, sex or age it is negatively correlated to the baseline 25(OH)D concentration. This study investigated whether the mean increase in serum 25(OH)D will be higher among participants with lower baseline 25(OH)D levels and whether the duration of supplementation has an influence on the serum 25(OH)D achieved.MethodsA clinical audit of patients’ medical records from a community health centre in Melbourne for the period 01.01.2010 to 31–12.2012 was undertaken. Paired sample t test was used to determine difference in pre and post dose serum 25(OH)D. Simple and multiple linear regressions were used to examine the association between the difference in pre and post dose serum 25(OH)D and duration of supplementation and baseline serum 25(OH)D, adjusting for socio-demographic factors.ResultsA total of 205 patients were included in the study. Mean difference in serum 25(OH)D was highest 52.8 nmol/L (95 % CI: 46.63–58.92) among those whose serum 25(OH)D was below 25 nmol/L at baseline. Baseline 25(OH)D alone accounted for 13.7 % of variance in the effect size (F(2, 202) = 16.0. p < 0.001), with the effect size significantly higher among participants with a baseline 25(OH)D level of 25–49 nmol/L (β = 11.93, 95 % CI: 0.48, 23.40, p < 0.05). Mean serum 25(OH)D difference was highest, 47.53 nmol/L (95 % CI: 40.95–54.11) when measured within 3 months of supplementation. Duration of supplementation explained 2.9 % of the variance in the effect size (F (1, 203) = 6.11, p < 0.05) and there was an inverse relationship between the length of supplementation and mean pre and post supplementation serum 25(OH)D difference (β = −1.45, 95 % CI: −2.62, −0.29, p = 0.014).ConclusionFollowing 50000 IU vitamin D3 for 12 months mean serum 25(OH)D increase was highest among those whose baseline serum 25(OH)D was lower. Migrants especially dark-skinned are at a high risk for vitamin D deficiency in Australia. High dose vitamin D3 50000 IU (cholecalciferol) is effective in achieving sufficient serum 25(OH)D among these populations who tend to have lower baseline serum 25(OH)D.

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Effects of 25-hydroxyvitamin D level and its change on parathyroid hormone in premenopausal Chinese women

Abstract: We conclude that vitamin D deficiency is common in young women in Hong Kong. The cross-sectional analysis indicates that optimal 25(OH)D is >40 nmol/L, and the longitudinal data is consistent with a higher optimal value which is not defined in this study's results.

Cited by 16 publications

References 44 publications

Vitamin D deficiency and biochemical variations among urban Saudi adolescent girls according to season

Vitamin D deficiency and biochemical variations among urban Saudi adolescent girls according to season

Vitamin D and health in adults in Australia and New Zealand: a position statement

Efficacy of high dose Vitamin D supplementation in improving serum 25(OH)D among migrant and non migrant population: a retrospective study

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