Mild parkinsonian signs and psycho-behavioral symptoms in subjects with mild cognitive impairment

Rozzini, Luca; Chilovi, Barbara Vicini; Bertoletti, Erik; Conti, Marta Zaffira; Delrio, Ilenia; Trabucchi, Marco; Padovani, Alessandro

doi:10.1017/s1041610207006163

Cited by 22 publications

(24 citation statements)

References 22 publications

(25 reference statements)

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“…In particular, the different personality traits [37] , the presence of hallucinations, sleep disturbances and extrapyramidal signs, included in the core features of LBD [38,39] , would suggest that Lewy body pathology might be a contributing factor to the clinical profile of naMCI.…”

Section: Discussionmentioning

confidence: 99%

Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Rozzini

Chilovi

Conti

et al. 2007

Dement Geriatr Cogn Disord

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Background: The information regarding neuropsychiatric symptoms in the subtypes of mild cognitive impairment (MCI) is inadequate. Objective: To describe the behavioral neuropsychiatric symptoms of MCI in two subgroups of MCI patients with different neuropsychological characteristics. Methods: MCI patients are classified as amnestic (aMCI) if they have a prominent memory impairment, either alone or with other cognitive impairments (multiple domains with amnesia), or nonamnestic (naMCI) if a single nonmemory domain is impaired alone or in combination with other nonmemory deficits (multiple domains without amnesia). The Neuropsychiatric Inventory (NPI) was administrated to detect behavioral and psychological disturbances observed by the caregiver. Results: 120 subjects were analyzed: 94 were classified as aMCI and 26 as naMCI. Subjects with aMCI were more compromised than those with naMCI on global cognitive functions. About 85% of MCI patients had some neuropsychiatric symptoms evaluated with the NPI and the most prevalent symptom was depression, followed by anxiety. A significantly higher prevalence of hallucinations and sleep disorders has been observed in the naMCI group in comparison with the aMCI group. Conclusion: Neuropsychiatric symptoms occur in the majority of persons with MCI and may be the earliest manifestation of different diseases, each one associated with different clinical profiles at the stage of MCI.

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Section: Discussionmentioning

confidence: 99%

Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Rozzini

Chilovi

Conti

et al. 2007

Dement Geriatr Cogn Disord

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“…Parkinson’s disease [PD]), and supranuclear palsy (PSP) also develop apathy at high rates but lower than those seen in disorders involving cortical dysfunction, such as AD and TBI (2–8). Apathy is also common in patients with thalamic lesions (9), vascular dementia (10–12), cerebrovascular accidents (CVA) (13;14), anoxic brain injury (13;14), multiple sclerosis (MS) (15;16), myotonic dystrophy (17;18), human immunodeficiency virus (19), major depressive disorder (18;20), and mild cognitive impairment (MCI) (21;22), especially when accompanied by extrapyramidal signs (1;8;16;23;24). The highest point prevalence rate found (84.1%) relate to nursing home residence (1;23).…”

Section: Introductionmentioning

confidence: 99%

Are the available apathy measures reliable and valid? A review of the psychometric evidence

Clarke

Kuhl

et al. 2011

Journal of Psychosomatic Research

181

149

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Objective Apathy is highly prevalent among neuropsychiatric populations and is associated with greater morbidity and worse functional outcomes. Despite this, it remains understudied and poorly understood, primarily due to lack of consensus definition and clear diagnostic criteria for apathy. Without a gold standard for defining and measuring apathy, the availability of empirically sound measures is imperative. This paper provides a psychometric review of the most commonly used apathy measures and provides recommendations for use and further research. Methods Pertinent literature databases were searched to identify all available assessment tools for apathy in adults aged 18 and older. Evidence of the reliability and validity of the scales were examined. Alternate variations of scales (e.g., non-English versions) were also evaluated if the validating articles were written in English. Results Fifteen apathy scales or subscales were examined. The most psychometrically robust measures for assessing apathy across any disease population appear to be the Apathy Evaluation Scale and the apathy subscale of the Neuropsychiatric Inventory based on the criteria set in this review. For assessment in specific populations, the Dementia Apathy Interview and Rating for patients with Alzheimer’s dementia, the Positive and Negative Symptom Scale for schizophrenia populations, and the Frontal System Behavior Scale for patients with fronto-temporal deficits are reliable and valid measures. Conclusion Clinicians and researchers have numerous apathy scales for use in broad and disease-specific neuropsychiatric populations. Our understanding of apathy would be advanced by research that helps build a consensus as to the definition and diagnosis of apathy, and further refine the psychometric properties of all apathy assessment tools.

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“…As is the case with dementia, neuropsychiatric symptoms (NPS) have not been included in the concept of MCI and only recently have various studies described the neuropsychiatric features of the condition [10]. NPS, which occurs in at least one-third of MCI subjects [10], have been associated with worse cognitive performance, functional disability, and mild extrapyramidal signs [11][12][13][14]. Furthermore, they have been proposed as independent risk factors for the development of MCI [15][16][17][18] as well as predictors of conversion from MCI to dementia and AD [18][19][20][21][22][23][24].…”

Section: Introductionmentioning

confidence: 99%

A Systematic Review of Neuropsychiatric Symptoms in Mild Cognitive Impairment

Monastero

Mangialasche

Camarda

et al. 2009

JAD

240

191

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Mild cognitive impairment (MCI) is a clinical concept proposed as an intermediate state between normal aging and dementia. This condition has multiple heterogeneous sources, including clinical presentation, etiology, and prognosis. Recently, the prevalence and associated features of neuropsychiatric symptoms (NPS) in MCI have been described. We systematically searched the PubMed database (last accessed on August 31, 2008) for articles on NPS in MCI. Included articles used strict selection criteria, and outcome variables were extracted in duplicate; of the 27 articles included, 14 (52%) used prospective cohorts. The global prevalence of NPS in MCI ranged from 35% to 85%. The most common behavioral symptoms were depression, anxiety, and irritability. Hospital-based samples reported a higher global prevalence of NPS than population-based studies; this discrepancy probably reflected differences in demographics, study setting, MCI diagnostic criteria, and behavioral instruments used. Prospective studies showed that NPS, particularly depression, may represent risk factors for MCI or predictors for the conversion of MCI to Alzheimer's disease (AD). NPS are very prevalent in subjects with MCI, displaying a similar pattern of symptoms compared to dementia and AD. Large cohort studies using standardized MCI criteria and behavioral instruments are required to evaluate the prognostic role of NPS in MCI.

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Mild parkinsonian signs and psycho-behavioral symptoms in subjects with mild cognitive impairment

Abstract: MCI may be associated with mild parkinsonian signs, the severity of which are related to the severity of cognitive impairment, in particular of non-memory functions, and to a differential pattern of psycho-behavioral symptoms.

Cited by 22 publications

References 22 publications

Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Are the available apathy measures reliable and valid? A review of the psychometric evidence

A Systematic Review of Neuropsychiatric Symptoms in Mild Cognitive Impairment

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