Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Rozzini, Luca; Chilovi, Barbara Vicini; Conti, Marta Zaffira; Delrio, Ilenia; Borroni, Barbara; Trabucchi, Marco; Padovani, Alessandro

doi:10.1159/000111133

Cited by 78 publications

(90 citation statements)

References 59 publications

(30 reference statements)

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“…As previously demonstrated, psychobehavioral symptoms are often present in the earlier phases of dementia due to neurodegenerative processes [35]. Moreover, previous studies [36,37] demonstrated that anxiety, depression and apathy are the disturbances more frequently found in the earliest phases of AD.…”

Section: Discussionmentioning

confidence: 85%

Prestroke Dementia: Characteristics and Clinical Features in Consecutive Series of Patients

Caratozzolo

Riva²,

Chilovi³

et al. 2014

Eur Neurol

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Background/Aim: The prestroke level of cognitive function should be taken into account in order to predict the impact of stroke on the subsequent risk of dementia. The aim of the present study was to investigate the presence and correlates of prestroke dementia (PSD) as well as to identify its clinical features. Methods: Premorbid clinical and cognitive features of 158 consecutively recruited patients with a diagnosis of acute cerebrovascular pathology were assessed by interviewing the caregivers using multidimensional assessment. Patients were divided into two groups (PSD group and prestroke nondemented group). Baseline cognitive, functional and behavioral variables and neuroradiological hallmarks (medial temporal lobe atrophy, MTLA) were compared between these two groups. Results: In a logistic regression model, older age (OR 1.05), female gender (OR 2.3), Neuropsychiatric Inventory total score (OR 1.1) and MTLA (OR 1.2) were the variables independently associated with PSD. Conclusions: These findings support the hypothesis that cognitive impairment in patients with stroke may not only be a direct consequence of the acute cerebrovascular event but also a consequence of underlying neurodegenerative pathology.

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Section: Discussionmentioning

confidence: 85%

Prestroke Dementia: Characteristics and Clinical Features in Consecutive Series of Patients

Caratozzolo

Riva²,

Chilovi³

et al. 2014

Eur Neurol

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“…Individuals with multiple-domain MCI experienced a similar frequency of depressive symptoms to individuals with Alzheimer's disease, which is greater than older people with normal cognitive functioning, although the symptoms were likely to be milder . One study showed that more individuals with non-amnestic MCI than individuals with the amnestic subtype of MCI had depressive symptoms, (Johnson et al, 2012) whereas another reported there were similar levels of symptoms of depression and anxiety for the amnestic and non-amnestic subtypes (Rozzini et al, 2008).…”

Section: Author (Year)mentioning

confidence: 99%

The Relationship Between Mild Cognitive Impairment and Mood in Older People

Yates¹

2018

Preprint

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Mild cognitive impairment (MCI) has received increasing attention since the early 1990s. However, considerable controversy exists over exactly how the concept of MCI is defined and measured, and the implications of assigning or receiving a diagnosis of MCI. There is evidence of a link between MCI and mood, but empirical work remains conflicted and inconclusive. The first chapter provides an overview of the MCI concept and highlights some of the issues surrounding its definition. Chapter 2 provides a detailed description of the methodology and background to the empirical work presented in Chapters 4-6. A systematic review of the literature forms the third chapter of this thesis and establishes the need for further study into the relationship between MCI and mood. Chapter 4 makes use of data from the first Cognitive Function and Ageing Study (MRC-CFAS I) to investigate the role of subjective memory complaints (SMC) in the relationship between MCI and mood over a two year period. The results indicated that SMC may be related more strongly to mood than to objective cognitive performance, which raises questions about whether SMC should be included as a criterion in the MCI definition. Chapter 5 clarifies these findings using data from a contemporary cohort in the Cognitive Function and Ageing Study Wales (CFAS Wales). Chapter 6 investigates the role of health in the relationship between MCI and mood, again using data from CFAS Wales. The findings suggest that health problems constitute a risk factor for developing depression and anxiety, which may in turn affect cognitive functioning. This presents a useful opportunity for intervention to improve the quality of life for older people by improving their physical health, or improving the management of long-term conditions. Social networks were investigated as an influential factor in the relationship between MCI and mood, using data from CFAS Wales. Whilst increases in social network size were associated with fewer mood problems and increased cognitive functioning, they did not moderate the relationship between the two. However, this finding still showed that having more social contacts is beneficial and important to the quality of life of older people. The last chapter presents a discussion of the findings in relation to each of the research questions outlined in Chapter 1. The chapter also includes a commentary on the methodological considerations that were faced when developing this thesis, the implications of the findings and directions for future research.

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“…Наиболее типично наличие зрительных галлюцинаций для деменции с тельцами Леви. Галлюцинации наблюдаются и на стадии умеренных КН не-амнестического типа [40].…”

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Cognitive and non-cognitive neuropsychiatric disorders in dementia and methods of their correction

Менделевич

2017

RJTAO

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Nevrologiya, neiropsikhiatriya, psikhosomatika = Neurology, neuropsychiatry, psychosomatics. 2017;9(2):65-70. DOI: http://dx.doi.org/10.14412/20749(2):65-70. DOI: http://dx.doi.org/10.14412/ -27119(2):65-70. DOI: http://dx.doi.org/10.14412/ -2017 Когнитивные и некогнитивные нейропсихические расстройства при деменции и методы их коррекции Позитивные демографические тенденции, наблюдае-мые в настоящее время и прогнозируемые в будущем, при-вели к увеличению продолжительности жизни, а также к связанному с этим негативному факту -увеличению рас-пространенности деменции. Если в 2000 г. в мире насчиты-валось 18 млн больных с деменцией, то к 2025 г. их число мо-жет увеличиться до 34 млн. В настоящее время деменция за-трагивает приблизительно 5% людей старше 65 лет, каждый 3-й взрослый старше 85 лет страдает болезнью Альцгеймера (БА) или другими формами деменции [1].Накопление сведений, касающихся этиологических вариантов деменции, высокой распространенности демен-ции смешанного (сосудисто-нейродегенеративного) типа, разнообразия клинического спектра начальных симптомов заболевания [2,3], привело к появлению нового определе-ния и диагностических критериев когнитивных нарушений (КН). Согласно последнему (2013) пересмотру международ-ных рекомендаций по диагностике психических рас-стройств (Diagnostic and statistical manual of mental diseases, DSM-V), термин «деменция» был заменен на «большое ней-рокогнитивное расстройство» [4]. Додементное расстрой-ство, обозначаемое как «малое нейрокогнитивное расстрой-ство», предполагает сохранность функционирования и не-зависимости. На смену прежней трактовке диагноза демен-ции как процесса, связанного прежде всего с нарушением функции памяти, и ориентации на деменцию альцгейме-ровского типа пришло более широкое толкование демен-ции как процесса развития разнообразных КН.Большое нейрокогнитивное расстройство характери-зуется как значительное снижение по сравнению с прежним уровнем одной или нескольких когнитивных функций (внимание, управляющие функции, память, речь, праксис, гнозис, социальный интеллект), которое подтверждается: жалобами пациента, информацией от третьих лиц, включая

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Neuropsychiatric Symptoms in Amnestic and Nonamnestic Mild Cognitive Impairment

Cited by 78 publications

References 59 publications

Prestroke Dementia: Characteristics and Clinical Features in Consecutive Series of Patients

Prestroke Dementia: Characteristics and Clinical Features in Consecutive Series of Patients

The Relationship Between Mild Cognitive Impairment and Mood in Older People

Cognitive and non-cognitive neuropsychiatric disorders in dementia and methods of their correction

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