Mikrobielle hydrierung des aromatischen systems von 17α-äthinylöstradiol

Schubert, K.; Rose, Gustav; Hörhold, C.

doi:10.1016/0022-4731(73)90052-6

Cited by 3 publications

(2 citation statements)

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“…The absorption maximum of product I was at 235 nm which is the same as given by Schubert et al [12] for 10fl-hydroxy-nor-ethisterone and characteristic for 3-keto-4-ene-steroids. The product was unacetylable in 10% acetic anhydride in pyridine at room temperature indicating the presence of a tertiary OH group.…”

Section: Bioconversion Of Norethisteronesupporting

confidence: 78%

“…Later, Ambrus et al [11] tested 312 fungal strains and found that only a limited number of them hydroxylated norethisterone. With Aspergillus flaous, hydroxylation, as well as hydrogenation of ring A of 17aethynylestradiol, was observed by Schubert et al [12]. In our work, the bioconversion of 17a-ethynyl steroids was effected with lla-hydroxylase of established activity from R. nigricans, induced with progesterone under standard conditions.…”

Section: Introductionsupporting

confidence: 74%

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The bioconversion of 17Î±-ethynyl steroids with 11Î±-hydroxylase ofRhizopus nigricans

Žakelj-Mavrič

Belič

Gottlieb

1986

FEMS Microbiology Letters

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The bioconversion of 17α‐ethynyl steroids was effected with 11α‐hydroxylase of Rhizopus nigricans. 7β‐Hydroxyethisterone was found after the bioconversion of ethisterone, and 10β‐ and 6β‐hydroxy derivatives after the bioconversion of norethisterone. It seems that the ethynyl group prevents steroid‐enzyme binding in the normal mode and thus inhibits the formation of an 11α‐hydroxylated product.

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Section: Bioconversion Of Norethisteronesupporting

confidence: 78%

Section: Introductionsupporting

confidence: 74%