Migratory, respiratory burst and mitogenic responses of leucocytes isolated from the gills of rainbow trout (Oncorhynchus mykiss)

Lin, S.-H.; Ellis, A.E.; Davidson, G.A.; Secombes, Chris J.

doi:10.1006/fsim.1998.0199

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…Gill cell suspensions from the dab ( Limanda limanda ) were exposed to LPS and PHA and the produced mitogenic responses indicated the presence of few B-cells and a preponderance of T-cells (Lin et al, 1999). Secondary lamellae are formed by a very thin epithelium that is supported by pillar cells.…”

Section: Gross Anatomy Of Maltmentioning

confidence: 99%

Mucosal immunoglobulins and B cells of teleost fish

Salinas

Zhang

Sunyer

2011

Developmental & Comparative Immunology

510

350

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As physical barriers that separate teleost fish from the external environment, mucosae are also active immunological sites that protect them against exposure to microbes and stressors. In mammals, the sites where antigens are sampled from mucosal surfaces and where stimulation of naive T and B lymphocytes occurs are known as inductive sites and are constituted by mucosa-associated lymphoid tissue (MALT). According to anatomical location, the MALT in teleost fish is subdivided into gut-associated lymphoid tissue (GALT), skin-associated lymphoid tissue (SALT), and gill-associated lymphoid tissue (GIALT). All MALT contain a variety of leukocytes, including, but not limited to, T cells, B cells, plasma cells, macrophages and granulocytes. Secretory immunoglobulins are produced mainly by plasmablasts and plasma cells, and play key roles in the maintenance of mucosal homeostasis. Until recently, teleost fish B cells were thought to express only two classes of immunoglobulins, IgM and IgD, in which IgM was thought to be the only one responding to pathogens both in systemic and mucosal compartments. However, a third teleost immunoglobulin class, IgT/IgZ, was discovered in 2005, and it has recently been shown to behave as the prevalent immunoglobulin in gut mucosal immune responses. The purpose of this review is to summarise the current knowledge of mucosal immunoglobulins and B cells of fish MALT. Moreover, we attempt to integrate the existing knowledge on both basic and applied research findings on fish mucosal immune responses, with the goal to provide new directions that may facilitate the development of novel vaccination strategies that stimulate not only systemic, but also mucosal immunity.

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Section: Gross Anatomy Of Maltmentioning

confidence: 99%

Mucosal immunoglobulins and B cells of teleost fish

Salinas

Zhang

Sunyer

2011

Developmental & Comparative Immunology

510

350

View full text Add to dashboard Cite

show abstract

“…The intestinal epithelium in teleosts is known to absorb antigen and subsequently transport to intestinal macrophages or to the circulation [17,21]. The gills possess an intricate vasculature [22] and an immune competent leukocyte population [23,24]. Antibody producing cells have been isolated from gills [25,26] and IgM has been detected in gill mucus [27] along with induced levels of specific antibodies [28].…”

Section: Introductionmentioning

confidence: 98%

Immune- and enzyme histochemical characterisation of leukocyte populations within lymphoid and mucosal tissues of Atlantic halibut (Hippoglossus hippoglossus)

Grove

Johansen

Reitan

et al. 2006

Fish & Shellfish Immunology

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“…The release of chemoattractants is an integral part of the defence mechanism where leucocytes are recruited into an infected or injured area (Lin et al, 1999). The increased movement of leucocytes not only determines the e$cacy of the cell-mediated inflammatory reaction, but also serves as a prelude to the initiation of a multi-faceted immune response (Pedrera et al, 1993).…”

Section: Discussionmentioning

confidence: 99%