Mid-term outcome of arthroscopic AMIC for the treatment of articular cartilage defects in the knee joint is equivalent to mini-open procedures

Schagemann, Jan C.; Behrens, P.; Paech, Andreas; Riepenhof, Helge; Kienast, B.; Mittelstädt, Hagen; Gille, Justus

doi:10.1007/s00402-018-2887-z

Cited by 38 publications

(38 citation statements)

References 23 publications

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“…7 Although a pattern of positive patient outcomes can be drawn from clinical studies, the long term success of such material remains debatable. [8][9][10] Many studies included patients that required additional surgical procedures such as osteotomies, it is therefore difficult to determine the benefit of AMIC alone. In addition, some studies reported patient outcomes declined significantly as early as after 1.5 years postoperation.…”

Section: Introductionmentioning

confidence: 99%

Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration

Tallia

et al. 2020

Biomater. Sci.

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Section: Introductionmentioning

confidence: 99%

Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration

Tallia

et al. 2020

Biomater. Sci.

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“…Rev Bras Ortop et al, 27 em 2018, compararam a técnica artroscópica do AMIC com a técnica mini open, semelhante à do presente trabalho, concluindo não haver diferença nos resultados a médio prazo, com 2 anos de seguimento. Dhollander et al 28 já reportaram melhoras satisfatórias após 2 anos de pós-operatório, porém uma tendência à deterioração do tecido de reparo, analisado pela RM.…”

Section: Discussionunclassified

Lesões condrais maiores tratadas com uso de membrana de colágeno – Condrogênese autóloga induzida por matriz - Apresentam maior aumento nos escores clínicos

Miyahira

Novaretti

Astur

et al. 2020

Rev Bras Ortop (Sao Paulo)

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Resumo Objetivo Avaliar clínica e radiologicamente os resultados do tratamento das lesões condrais com a membrana de colágeno – condrogênese autóloga induzida por matriz. Métodos Trata-se de uma série de casos observacional, na qual foram analisados 15 pacientes submetidos a condrogênese autóloga induzida por matriz. A avaliação clínica foi feita comparando os escores de Lysholm e International Knee Document Commitee (IKDC, na sigla em inglês) no pré- e pós-operatório de 12 meses, e avaliação radiológica através do escore de Magnetic Resonance Observation of Cartilage Repair Tissue (MOCART, na sigla em inglês) no mesmo período de pós-operatório. Resultados A média de idade dos pacientes foi 39,2 anos, e a média do tamanho das lesões condrais foi de 1,55cm2. Houve uma melhora significativa nos escores clínicos, com média de aumento de 24,6 pontos no Lysholm e de 24,3 no IKDC, após 12 meses. Na avaliação radiológica, o MOCART teve média de 65 pontos. Observou-se que quanto maior o tamanho da lesão, maior foi a melhora nos escores. Conclusão Avaliando escores clínicos subjetivos, o tratamento das lesões condrais com a membrana de colágeno mostrou bons resultados, assim como a avaliação de MOCART, com maior benefício em lesões maiores.

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“…Nonetheless, natural polymers are most widely used in ongoing clinical studies, with collagen being the most common. Collagen scaffolds provide the foundation for autologous matrix-induced chondrogenesis, both cell-free [120,121,122] and cell-assisted [120,123]. Of particular interest is MACI aided by collagen [124,125,126], hyaluronic acid [127,128], or fibrin glue [129].…”

Section: Tissue-engineered Constructsmentioning

confidence: 99%

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

Medvedeva

Grebenik

Gornostaeva

et al. 2018

IJMS

198

152

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Articular hyaline cartilage is extensively hydrated, but it is neither innervated nor vascularized, and its low cell density allows only extremely limited self-renewal. Most clinical and research efforts currently focus on the restoration of cartilage damaged in connection with osteoarthritis or trauma. Here, we discuss current clinical approaches for repairing cartilage, as well as research approaches which are currently developing, and those under translation into clinical practice. We also describe potential future directions in this area, including tissue engineering based on scaffolding and/or stem cells as well as a combination of gene and cell therapy. Particular focus is placed on cell-based approaches and the potential of recently characterized chondro-progenitors; progress with induced pluripotent stem cells is also discussed. In this context, we also consider the ability of different types of stem cell to restore hyaline cartilage and the importance of mimicking the environment in vivo during cell expansion and differentiation into mature chondrocytes.

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Mid-term outcome of arthroscopic AMIC for the treatment of articular cartilage defects in the knee joint is equivalent to mini-open procedures

Abstract: III.

Cited by 38 publications

References 23 publications

Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration

Scaffold channel size influences stem cell differentiation pathway in 3-D printed silica hybrid scaffolds for cartilage regeneration

Lesões condrais maiores tratadas com uso de membrana de colágeno – Condrogênese autóloga induzida por matriz - Apresentam maior aumento nos escores clínicos

Repair of Damaged Articular Cartilage: Current Approaches and Future Directions

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