Microwave-Assisted Synthesis of Mesoporous Silica Nanoparticles as a Drug Delivery Vehicle

Kamarudin, Nur Hidayatul Nazirah; Jalil, Aishah Abdul; Triwahyono, Sugeng; Timmiati, Sharifah Najiha

doi:10.17576/mjas-2016-2006-17

Cited by 8 publications

(11 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…the TEM images shows uniformly the hexagon pattern and shape of the MSN. The MSN shape obtained in this study is similar as found by Kamarudin et al (2016). Meanwhile, Figure 2B shows the pattern structural of particles was in uniform pattern with the average sizes from 70 to 150 nm.…”

Section: Resultssupporting

confidence: 86%

“…The peak appeared at 4.95 proved the formation of the mesoporous characteristic on the synthesized silica. This peak was in good agreement with literature to prove the formation of MSN (heikkila et al 2010;Kamarudin et al 2016). 61 The characterization using TEM and FeSeM were conducted to observe the pattern of pore surface structural, and topography of the MSN.…”

Section: Resultssupporting

confidence: 86%

“…The method used for the MSN preparation was adopted from Kamarudin et al (2016). About 4.68 g of cetyltrimethylammonium bromide (CTAB), 120 mL of ethylene glycol (EG) and 29 mL of 25% ammonium hydroxide (NH 4 OH) were dissolved in 720 mL of distilled water and was heated at 50 o for about 30 min with a vigorous stirring.…”

Section: Synthesis Of Mesoporous Silicamentioning

confidence: 99%

See 2 more Smart Citations

Synthesis of Mesoporous Silica for Ammonia Adsorption in Aqueous Solution

Arifin¹,

Hasan²,

Kamarudin³

et al. 2018

JKUKM

Self Cite

View full text Add to dashboard Cite

In this work, mesoporous silica (MSN) was synthesized and tested for ammonia adsorption. The synthesized MSN was characterized using the Fourier Transform Infrared (FTIR), Scanning Electron Microscopy (SEM), Transmission Electron Microscopy (TEM), and Brunauer-Emmett-Teller (BET). In the ammonia adsorption experimental, the mass of MSN was varied at 0.5, 1.0, 1.5, 2.0 and 2. 5 g. The data of ammonia uptake by MSN was plotted using Langmuir and Freundlich isotherms, while the kinetic adsorptions were determined using pseudo-first order and pseudo-second order kinetics. The results showed the MSN structural was hexagonal form and particle size of 70 to 150 nm. Characterization using FTIR shows the MSN contained various chemical functional groups. The adsorption of ammonia rest resulted with a high percentage of ammonia removal. At 0.5, 1.0, 1.5, 2.0, 2.5 and 3.0 g of MSN, the highest adsorption uptake at 5 minutes were 0. 79, 0.42, 0.31, 0.21, 0.17 and 0.12 mg/g, respectively. The adsorption data were fitted to the isotherm and kinetic models to predict the mechanism and kinetic characteristics of the adsorption process. The Freundlich isotherm model shows the highest correlation with the Freunclidh (K F ) and adsorption constant (n) of 6.78 and 0.39 mg/g, respectively. For the kinetic modeling, the data of ammonia adsorption process were well fitted to the pseudo-second order with coefficient determination (R 2 ) value of 0.9992. These results indicated the potential for a new application of MSN as an effective adsorbent for ammonia removal and it can be applied in the water treatment processes. Brunauer-Emmett-Teller (BET). Dalam uji kaji penjerapan ammonia, jisim MSN diubah pada 0.5, 1.0, 1.5, 2.0 dan 2. 5 g. Data pengambilan ammonia oleh MSN telah diplot menggunakan isoterma Langmuir dan Freundlich, sementara kinetik penjerapan telah ditentukan dengan menggunakan kinetik urutan pseudopertama dan kinetik urutan pseudo-kedua. Keputusan menunjukkan struktur MSN adalah berbentuk heksagon dengan saiz partikel antara 70 -150 nm. Pencirian melalui FTIR pula menunjukkan MSN mempunyai pelbagai kumpulan kimia berfungsi. Saiz liang MSN yang besar telah menghasilkan peratusan penyingkiran ammonia yang tinggi. Pada jisim MSN sebanyak 0.5, 1.0, 1.5, 2.0, 2.5 dan 3.0 g, 0.42, 0.31, 0.21, 0.17 and 0.12 mg/g. Data penjerapan diplot pada model isoterma dan kinetik untuk meramalkan mekanisme dan ciri-ciri kinetik proses penjerapan ammonia. Model isoterma Freundlich menunjukkan korelasi tertinggi dengan pemalar Freunclidh (K F ) dan penjerapan (n) masing-masing sebanyak 6.78 dan 0.39 mg/g. Pemodelan kinetik menunjukkan data penjerapan ammonia berpadanan dengan pesanan pseudo-kedua dengan nilai penentuan koefisien (R 2 ) sebanyak 0.9992. Ini menunjukkan potensi aplikasi MSN sebagai penjerap berkesan untuk penyingkiran ammonia dan boleh diaplikasikan dalam proses rawatan air. ABSTRAK Dalam kajian ini, silika mesoliang (MSN) telah disintesis dan diuji untuk penjerapan ammonia. Pencirian terhadap MSN dilakukan dengan menggunakan ...

show abstract

Section: Resultssupporting

confidence: 86%

Section: Resultssupporting

confidence: 86%

See 1 more Smart Citation

Synthesis of Mesoporous Silica for Ammonia Adsorption in Aqueous Solution

Arifin¹,

Hasan²,

Kamarudin³

et al. 2018

JKUKM

Self Cite

View full text Add to dashboard Cite

show abstract

“…This result is in good agreement with the literature [ 36 ], demonstrating that the silica shell deposition was favored by the positively charged of gentamicin on the silica particle surface. Kamarudin et al [ 29 ] showed that the variation in microwave power led to modification in the material’s structure. The studies indicated that the complete adsorption of ibuprofen that was obtained using mesoporous silica nanoparticles prepared at microwave power of 450 W was possible due to the higher surface area and fewer irregularities in the morphology.…”

Section: Resultsmentioning

confidence: 99%

“…The results showed that the mesoporous ZnO matrix presented different behaviors and drug-loading efficiencies, depending on the GS loading solution. Kamarudin et al [ 29 ] showed that the mesoporous silica nanoparticles, prepared by using microwave synthesis, exhibited the ibuprofen adsorption. It was observed that the mesoporous structure of silica nanoparticles can be modified as function of the used microwave power (from 100 to 450 W).…”

Section: Introductionmentioning

confidence: 99%

Preparation and Characterization of Silica Nanoparticles and of Silica-Gentamicin Nanostructured Solution Obtained by Microwave-Assisted Synthesis

et al. 2021

View full text Add to dashboard Cite

In this research work, silica nanoparticles and silica-gentamicin nanostructured solution were synthesized by using the microwave-assisted synthesis, in basic medium, using two silane precursors (tetraethylorthosilicate and octyltriethoxysilane) and the antibiotic (gentamicin sulfate). The prepared materials were characterized through Fourier transform infrared (FTIR) spectroscopy, TGA analysis, transmission electron microscopy (TEM), and atomic force microscopy (AFM) to investigate the morphology and structure. Antimicrobial studies of the silica-gentamicin nanostructured solution versus silica nanoparticles were performed against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. FTIR spectra showed that the gentamicin has been loaded to the silica nanoparticles. AFM analysis showed that the morphology of the silica-gentamicin nanostructured solution has changed, and agglomerations of particles are present at the surface. Antimicrobial testing, performed using the diffusion method through spot inoculation, indicates that the silica-gentamicin nanostructured solution exhibited activity against the resistant strain. The obtained silica-gentamicin solution can be used as biochemical agent for the prevention and treatment of microorganisms which are deposited on different surfaces (e.g., glass, plastic, ceramic).

show abstract