Mesoporous silica nanoparticles for drug combination delivery in cancer therapy

Day, Candace M.; Sweetman, Martin J.; Garg, Sanjay

doi:10.1016/b978-0-12-820779-6.00004-9

Cited by 4 publications

(2 citation statements)

References 193 publications

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“…In addition to this, during the development of new drug products, assuring the long-term stability of a liposomal formulation is critical. Furthermore, much research involving microspheres and nanoparticle-based DDSs conducted in-vivo evaluations on animals, and they need more clinical trials to prove their safety and efficacy, especially when the fate of nano-/microparticles in the body following administration remains a hot debate [ 177 ]. In addition to this, no guidelines have been published for the in-vitro release testing of sustained release parenteral formulations, making it difficult to test the release as it varies with the method used for the testing.…”

Section: Conclusion and Future Perspectivementioning

confidence: 99%

The Management of Parkinson’s Disease: An Overview of the Current Advancements in Drug Delivery Systems

Nakmode,

Day,

Song

et al. 2023

Pharmaceutics

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Parkinson’s disease (PD) has significantly affected a large proportion of the elderly population worldwide. According to the World Health Organization, approximately 8.5 million people worldwide are living with PD. In the United States, an estimated one million people are living with PD, with approximately 60,000 new cases diagnosed every year. Conventional therapies available for Parkinson’s disease are associated with limitations such as the wearing-off effect, on-off period, episodes of motor freezing, and dyskinesia. In this review, a comprehensive overview of the latest advances in DDSs used to reduce the limitations of current therapies will be presented, and both their promising features and drawbacks will be discussed. We are also particularly interested in the technical properties, mechanism, and release patterns of incorporated drugs, as well as nanoscale delivery strategies to overcome the blood–brain barrier.

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Section: Conclusion and Future Perspectivementioning

confidence: 99%

The Management of Parkinson’s Disease: An Overview of the Current Advancements in Drug Delivery Systems

Nakmode,

Day,

Song

et al. 2023

Pharmaceutics

Self Cite

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“…Gao and co-workers focused on chemotherapy and other combinatorial interventions like gene therapy, immunotherapy, and stimuli-responsive systems for targeting cancer cells . A few other reports on similar topics have been published. − However, insights on clinical translation, MSN-based vaccines, biomimetic therapeutics, and their theranostic potential in cancer targeting have not yet been comprehensively explained in a single compilation.…”

Section: Introductionmentioning

confidence: 99%

Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

et al. 2022

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The global menace of cancer has led to an increased death toll in recent years. The constant evolution of cancer therapeutics with novel delivery systems has paved the way for translation of innovative therapeutics from bench to bedside. This review explains the significance of mesoporous silica nanoparticles (MSNs) as delivery vehicles with particular emphasis on cancer therapy, including novel opportunities for biomimetic therapeutics and vaccine delivery. Parameters governing MSN synthesis, therapeutic agent loading characteristics, along with tuning of MSN toward cancer cell specificity have been explained. The advent of MSN in nanotheranostics and its potential in forming nanocomposites for imaging purposes have been illustrated. Additionally, various hurdles encountered during the bench to bedside translation have been explained along with potential avenues to circumvent them. This also opens up new horizons in drug delivery, which could be useful to researchers in the years to come.

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