Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

Shah, Saurabh; Famta, Paras; Bagasariya, Deepkumar; Charankumar, Kondasingh; Sikder, Anupama; Kashikar, Rama; Kotha, Arun K.; Chougule, Mahavir B.; Khatri, Dharmendra Kumar; Asthana, Amit; Raghuvanshi, Rajeev Singh; Singh, Shashi Bala; Srivastava, Saurabh

doi:10.1021/acs.molpharmaceut.2c00374

Cited by 16 publications

(8 citation statements)

References 215 publications

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“…This study aimed to determine whether these particles could track brain disorder. 198 Nanomaterial fabrication and characterization must be carefully considered when building drug delivery systems 199 to reduce NC toxicity in healthy cells. This organized and defined process evaluates the advantages and disadvantages of these medications.…”

Section: Challenges and Alternative Approachesmentioning

confidence: 99%

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

Mohapatra,

Gopikrishnan,

Doss C

et al. 2024

IJN

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New nanotechnology strategies for enhancing drug delivery in brain disorders have recently received increasing attention from drug designers. The treatment of neurological conditions, including brain tumors, stroke, Parkinson’s Disease (PD), and Alzheimer’s disease (AD), may be greatly influenced by nanotechnology. Numerous studies on neurodegeneration have demonstrated the effective application of nanomaterials in the treatment of brain illnesses. Nanocarriers (NCs) have made it easier to deliver drugs precisely to where they are needed. Thus, the most effective use of nanomaterials is in the treatment of various brain diseases, as this amplifies the overall impact of medication and emphasizes the significance of nanotherapeutics through gene therapy, enzyme replacement therapy, and blood-barrier mechanisms. Recent advances in nanotechnology have led to the development of multifunctional nanotherapeutic agents, a promising treatment for brain disorders. This novel method reduces the side effects and improves treatment outcomes. This review critically assesses efficient nano-based systems in light of obstacles and outstanding achievements. Nanocarriers that transfer medications across the blood-brain barrier and nano-assisted therapies, including nano-immunotherapy, nano-gene therapy, nano enzyme replacement therapy, scaffolds, and 3D to 6D printing, have been widely explored for the treatment of brain disorders. This study aimed to evaluate existing literature regarding the use of nanotechnology in the development of drug delivery systems that can penetrate the blood-brain barrier (BBB) and deliver therapeutic agents to treat various brain disorders.

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Section: Challenges and Alternative Approachesmentioning

confidence: 99%

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

Mohapatra,

Gopikrishnan,

Doss C

et al. 2024

IJN

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“…The importance of MSNs in drug delivery research is highlighted by their biocompatibility, variable porosity, controlled drug release, high loading capacity, and stability. 132 , 133 Lin et al 103 prepared highly ordered MSNs with a pore size of 2.754 nm and a particle size of 115 ± 15 nm using an etching method. Homogeneous polyethylene glycolized lipid bilayers with a thickness of 10–15 nm were wrapped around the MSN surface using a thin film hydration method.…”

Section: Curcumin Drug Delivery Systems In Breast Cancermentioning

confidence: 99%

Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

Huang¹,

Zhai²,

Fan³

et al. 2023

IJN

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Breast cancer (BC) is the most prevalent type of cancer in the world and the main reason women die from cancer. Due to the significant side effects of conventional treatments such as chemotherapy and radiotherapy, the search for supplemental and alternative natural drugs with lower toxicity and side effects is of interest to researchers. Curcumin (CUR) is a natural polyphenol extracted from turmeric. Numerous studies have demonstrated that CUR is an effective anticancer drug that works by modifying different intracellular signaling pathways. CUR's therapeutic utility is severely constrained by its short half-life in vivo, low water solubility, poor stability, quick metabolism, low oral bioavailability, and potential for gastrointestinal discomfort with high oral doses. One of the most practical solutions to the aforementioned issues is the development of targeted drug delivery systems (TDDSs) based on nanomaterials. To improve drug targeting and efficacy and to serve as a reference for the development and use of CUR TDDSs in the clinical setting, this review describes the physicochemical properties and bioavailability of CUR and its mechanism of action on BC, with emphasis on recent studies on TDDSs for BC in combination with CUR, including passive TDDSs, active TDDSs and physicochemical TDDSs.

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“…Several nano-formulations including Abraxane ® , Genexol-PM, Caelyx, and Onivyde have been approved for treating metastatic cancer [ 208 ]. In addition, nanoparticles formulated using inorganic materials such as gold [ 209 ], silver [ 210 ], and mesoporous silica [ 211 ] have demonstrated great potential for implementing novel modalities such as photodynamic and photothermal therapy [ 212 , 213 , 214 ]. For cancer therapy, use of nano-delivery systems allows cellular toxins [ 215 ], radioisotopes [ 216 ], and chemotherapeutic agents [ 217 , 218 ] to be targeted to a greater extent to the tumor cells with minimal effects on normal cells.…”

Section: Strategies For Targeting Stromal Interactionsmentioning

confidence: 99%

Nanomedicine Strategies for Targeting Tumor Stroma

Su,

Nethi,

Dhanyamraju

et al. 2023

Cancers

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The tumor stroma, or the microenvironment surrounding solid tumors, can significantly impact the effectiveness of cancer therapies. The tumor microenvironment is characterized by high interstitial pressure, a consequence of leaky vasculature, and dense stroma created by excessive deposition of various macromolecules such as collagen, fibronectin, and hyaluronic acid (HA). In addition, non-cancerous cells such as cancer-associated fibroblasts (CAFs) and the extracellular matrix (ECM) itself can promote tumor growth. In recent years, there has been increased interest in combining standard cancer treatments with stromal-targeting strategies or stromal modulators to improve therapeutic outcomes. Furthermore, the use of nanomedicine, which can improve the delivery and retention of drugs in the tumor, has been proposed to target the stroma. This review focuses on how different stromal components contribute to tumor progression and impede chemotherapeutic delivery. Additionally, this review highlights recent advancements in nanomedicine-based stromal modulation and discusses potential future directions for developing more effective stroma-targeted cancer therapies.

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Tuning Mesoporous Silica Nanoparticles in Novel Avenues of Cancer Therapy

Cited by 16 publications

References 215 publications

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

How Precise are Nanomedicines in Overcoming the Blood–Brain Barrier? A Comprehensive Review of the Literature

Targeted Drug Delivery Systems for Curcumin in Breast Cancer Therapy

Nanomedicine Strategies for Targeting Tumor Stroma

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