Preparation and Characterization of Silica Nanoparticles and of Silica-Gentamicin Nanostructured Solution Obtained by Microwave-Assisted Synthesis

Abstract

In this research work, silica nanoparticles and silica-gentamicin nanostructured solution were synthesized by using the microwave-assisted synthesis, in basic medium, using two silane precursors (tetraethylorthosilicate and octyltriethoxysilane) and the antibiotic (gentamicin sulfate). The prepared materials were characterized through Fourier transform infrared (FTIR) spectroscopy, TGA analysis, transmission electron microscopy (TEM), and atomic force microscopy (AFM) to investigate the morphology and structure. Antimicrobial studies of the silica-gentamicin nanostructured solution versus silica nanoparticles were performed against Pseudomonas aeruginosa, Staphylococcus aureus, and Escherichia coli. FTIR spectra showed that the gentamicin has been loaded to the silica nanoparticles. AFM analysis showed that the morphology of the silica-gentamicin nanostructured solution has changed, and agglomerations of particles are present at the surface. Antimicrobial testing, performed using the diffusion method through spot inoculation, indicates that the silica-gentamicin nanostructured solution exhibited activity against the resistant strain. The obtained silica-gentamicin solution can be used as biochemical agent for the prevention and treatment of microorganisms which are deposited on different surfaces (e.g., glass, plastic, ceramic).

Development and Characterization of Gentamicin-Loaded Arabinoxylan-Sodium Alginate Films as Antibacterial Wound Dressing

“…On the other hand, SA showed thermal decomposition at T range < 105 °C (∆W = 5.7%), 265–415 °C (∆W = 71.3%, T max = 330 °C), and >415 °C (∆W = 12.5%) due to water loss, fragmentation of polysaccharide backbone of SA and complete degradation [ 27 ]. Similarly, GS underwent thermal degradation at T range < 120 °C (∆W = 13.7%), 245–295 °C (∆W = 13.4%, T max = 274 °C), 295–370 °C (∆W = 25.9%, T max = 330 °C), and >370 °C (∆W = 35.5%), which shows that thermal decomposition of GS starts at 245 °C [ 46 ].…”

Zinc-Containing Sol–Gel Glass Nanoparticles to Deliver Therapeutic Ions

“…BAGs have been recently developed in nano-sized particles to use as therapeutic carriers because of their ability to enhance the cells’ uptake ability and increase bioactive properties through the release of ions locally inside the cells [ 5 , 6 , 7 ]. As nanotechnology has been intensively introduced in medical applications, such as using nanoparticles (NPs), including gold nanoparticles, superparamagnetic nanoparticles, lipid-based nanoparticles, polymeric nanoparticles, and silica nanoparticles [ 8 , 9 , 10 ], in drug delivery systems and imaging because of their unique properties, including a high specific area-to-volume ratio, bioactive glass nanoparticles (BAGNPs) have been introduced to improve the properties of BAGs. BAGNPs have been widely used in biomedical applications because of their small size, large specific surface area, and their large surface-to-volume ratio that gives them special properties [ 11 ].…”

“…The BAGNPs have had their compositions developed to improve the properties and clinical abilities of traditional BAGNPs over time. Recently, the incorporation of different elements, such as silver (Ag), manganese (Mn), magnesium (Mg), strontium (Sr), zinc (Zn), aluminium (Al), fluorine (F), and potassium (P), into the composition of these BAGNPs to enhance their physical characteristics and therapeutic benefits has been of particular interest [ 10 , 19 , 20 , 21 , 22 ]. Strontium (Sr) is a beneficial trace element in the human body, which represents only 0.035% of the calcium (Ca) content in the skeleton structure [ 23 ].…”

Silica Nanoparticle Acute Toxicity on Male Rattus norvegicus Domestica: Ethological Behavior, Hematological Disorders, Biochemical Analyses, Hepato-Renal Function, and Antioxidant-Immune Response

“…Among NPs, silica nanoparticles (SiNPs) are one of the top five nanomaterials involved in nanotech-based consumer products ( Park et al, 2011 ). Currently, silica nanoparticles (SiNPs) are widely used in different fields in food additives, drug delivery, medicine, and disease treatments ( Selvarajan et al, 2020 ; Purcar et al, 2021 ) because of their unique characteristics such as remarkable biocompatibility, stability, large surface area, and surface reactivity ( Gubala et al, 2020 ; Karande et al, 2021 ). The broad usage increases the human and animal exposure to different types of nanoparticles inducing toxicity ( Bahadar et al, 2016 ; Mahboub H. H. et al, 2021 ).…”