Microwave-assisted extraction of phenolic compounds from <i>Cannabis sativa</i> L.: optimization and kinetics study

Matešić, Nikolina; Jurina, Tamara; Benković, Maja; Panić, Manuela; Valinger, Davor; Kljusurić, Jasenka Gajdoš; Tušek, Ana Jurinjak

doi:10.1080/01496395.2020.1804938

Cited by 24 publications

(19 citation statements)

References 29 publications

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“…The residual vs. predicted value plots ( Figure 2 a,b) reveal that the residuals have no pattern, implying that the models match the experimental data well. Additionally, the residuals were found to range around the central value ( Figure 2 a,b) without obvious outliers, which means that the level of randomization was appropriate and that the sequence of testing had no effect on the findings [ 19 ].…”

Section: Resultsmentioning

confidence: 99%

Prediction of pH Value of Aqueous Acidic and Basic Deep Eutectic Solvent Using COSMO-RS σ Profiles’ Molecular Descriptors

et al. 2022

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The aim of this work was to develop a simple and easy-to-apply model to predict the pH values of deep eutectic solvents (DESs) over a wide range of pH values that can be used in daily work. For this purpose, the pH values of 38 different DESs were measured (ranging from 0.36 to 9.31) and mathematically interpreted. To develop mathematical models, DESs were first numerically described using σ profiles generated with the COSMOtherm software. After the DESs’ description, the following models were used: (i) multiple linear regression (MLR), (ii) piecewise linear regression (PLR), and (iii) artificial neural networks (ANNs) to link the experimental values with the descriptors. Both PLR and ANN were found to be applicable to predict the pH values of DESs with a very high goodness of fit (R2independent validation > 0.8600). Due to the good mathematical correlation of the experimental and predicted values, the σ profile generated with COSMOtherm could be used as a DES molecular descriptor for the prediction of their pH values.

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Section: Resultsmentioning

confidence: 99%

Prediction of pH Value of Aqueous Acidic and Basic Deep Eutectic Solvent Using COSMO-RS σ Profiles’ Molecular Descriptors

et al. 2022

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“…The extraction time had a negative impact on TPC but had no significant effect on TFC [70]. The temperature and its interaction with microwave power were found to have a significant effect on TPC as well [71]. The optimum operating conditions for TPC extraction gave the highest DPPH inhibition and reducing power [70].…”

Section: Other Extraction Techniquesmentioning

confidence: 93%

“…However, regarding the extraction of phenolic compounds from cannabis, only three articles were identified. Drinić et al (2020) [70] and Matešić et al (2020) [71] focused on the optimization of MAE operating conditions during PC extraction from hemp. Both studies worked with ethanol:water at different ratios.…”

Section: Other Extraction Techniquesmentioning

confidence: 99%

Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

2021

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Cannabis sativa L. is a controversial crop due to its high tetrahydrocannabinol content varieties; however, the hemp varieties get an increased interest. This paper describes (i) the main categories of phenolic compounds (flavonoids, stilbenoids and lignans) and terpenes (monoterpenes and sesquiterpenes) from C. sativa by-products and their biological activities and (ii) the main extraction techniques for their recovery. It includes not only common techniques such as conventional solvent extraction, and hydrodistillation, but also intensification and emerging techniques such as ultrasound-assisted extraction or supercritical CO2 extraction. The effect of the operating conditions on the yield and composition of these categories of phenolic compounds and terpenes was discussed. A thorough investigation of innovative extraction techniques is indeed crucial for the extraction of phenolic compounds and terpenes from cannabis toward a sustainable industrial valorization of the whole plant.

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“…MW pre-treatments on rosemary leaves resulted in almost two times the phytochemical concentration during storage compared to the untreated leaves [ 50 ]. Phytocannabinoid extraction with the assistance of MW shows a significant improvement of the process output [ 51 , 52 , 53 , 54 ]. To prompt the drying process and to improve the polyphenol, cannabinoid, and terpene profile of cannabis, MW heating could be an ideal pre-treatment.…”

Section: Postharvest Operations Involved In Cannabismentioning

confidence: 99%

Postharvest Operations of Cannabis and Their Effect on Cannabinoid Content: A Review

et al. 2022

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In recent years, cannabis (Cannabis sativa L.) has been legalized by many countries for production, processing, and use considering its tremendous medical and industrial applications. Cannabis contains more than a hundred biomolecules (cannabinoids) which have the potentiality to cure different chronic diseases. After harvesting, cannabis undergoes different postharvest operations including drying, curing, storage, etc. Presently, the cannabis industry relies on different traditional postharvest operations, which may result in an inconsistent quality of products. In this review, we aimed to describe the biosynthesis process of major cannabinoids, postharvest operations used by the cannabis industry, and the consequences of postharvest operations on the cannabinoid profile. As drying is the most important post-harvest operation of cannabis, the attributes associated with drying (water activity, equilibrium moisture content, sorption isotherms, etc.) and the significance of novel pre-treatments (microwave heating, cold plasma, ultrasound, pulse electric, irradiation, etc.) for improvement of the process are thoroughly discussed. Additionally, other operations, such as trimming, curing, packaging and storage, are discussed, and the effect of the different postharvest operations on the cannabinoid yield is summarized. A critical investigation of the factors involved in each postharvest operation is indeed key for obtaining quality products and for the sustainable development of the cannabis industry.

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Microwave-assisted extraction of phenolic compounds from Cannabis sativa L.: optimization and kinetics study

Cited by 24 publications

References 29 publications

Prediction of pH Value of Aqueous Acidic and Basic Deep Eutectic Solvent Using COSMO-RS σ Profiles’ Molecular Descriptors

Prediction of pH Value of Aqueous Acidic and Basic Deep Eutectic Solvent Using COSMO-RS σ Profiles’ Molecular Descriptors

Extraction of Phenolic Compounds and Terpenes from Cannabis sativa L. By-Products: From Conventional to Intensified Processes

Postharvest Operations of Cannabis and Their Effect on Cannabinoid Content: A Review

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