Microvascular Invasion in Patients with Hepatocellular Carcinoma and Its Predictable Clinicopathological Factors

Sumie, Shuji; Kuromatsu, Ryoko; Okuda, K; Ando, Eiji; Takata, Akio; Fukushima, Nobuyoshi; Watanabe, Yasutomo; Kojiro, Masamichi; Sata, Michio

doi:10.1245/s10434-008-9846-9

Cited by 345 publications

(298 citation statements)

References 31 publications

Supporting

Mentioning

276

Contrasting

Order By: Relevance

“…Liver cirrhosis is established through repetitive necroinflammation and regeneration. Several investigators have also reported that liver cirrhosis is significant risk factor for recurrence after resection for HCC (Portolani et al, 2006;Sumie et al, 2008;Ho et al, 2012). In our study, we found that the degree of liver cirrhosis is the only significant risk factor for postoperative late intrahepatic recurrence.…”

Section: Discussionsupporting

confidence: 67%

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

Li¹,

Guo²,

Xiao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Section: Discussionsupporting

confidence: 67%

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

Li¹,

Guo²,

Xiao³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…Recently, clinical studies come to emphasize on the affection that microvascular invasion on HCC patients prognosis (Colombo et al, 2011).There is literature shows that microvascular invasion is a risk factor for disease-free survival rate, the 5-year disease-free survival rate in groups with and without microvascular invasion are 20.8% and 52.6%, respectively (Sumie et al, 2008). Therefore, in the recent six edition TNM classification system proposed by the UICC/AJCC revise T1 stage as single tumor without vascular invasion and dispose the standard that tumor size ≤2cm.…”

Section: Discussionmentioning

confidence: 99%

Long-term Prognosis in Hepatocellular Carcinoma Patients after Hepatectomy

Zhou¹,

Liu²,

Fang³

et al. 2012

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…9,10 AFP is associated with grade differentiation, 11 whereas PIVKA-II is related to vascular invasion. 12,13 However, these tumor markers have limited sensitivity and are less predictive than microvascular invasion, 14,15 which is the most potent determinant of recurrence and survival in HCC patients undergoing a hepatectomy. 5 Therefore, new biomarkers that are more strongly associated with prognosis and recurrence in HCC than AFP or PIVKA-II are highly desirable.…”

mentioning

confidence: 99%

Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis

et al. 2013

View full text Add to dashboard Cite

The altered N-glycosylation of glycoproteins has been suggested to play an important role in the behavior of malignant cells. Using glycomics technology, we attempted to determine the specific and detailed N-glycan profile for hepatocellular carcinoma (HCC) and investigate the prognostic capabilities. From 1999 to 2011, 369 patients underwent primary curative hepatectomy in our facility and were followed up for a median of 60.7 months. As normal controls, 26 living Japanese related liver transplantation donors were selected not infected by hepatitis B and C virus. Their mean age was 40.0 and 15 (57.7%) were male. We used a glycoblotting method to purify N-glycans from preoperative blood samples from this cohort (10 lL serum) which were then identified and quantified using mass spectrometry (MS). Correlations between the N-glycan levels and the clinicopathologic characteristics and outcomes for these patients were evaluated. Our analysis of the relative areas of all the sugar peaks identified by MS, totaling 67 N-glycans, revealed that a proportion had higher relative areas in the HCC cases compared with the normal controls. Fourteen of these molecules had an area under the curve of greater than 0.80. Analysis of the correlation between these 14 N-glycans and surgical outcomes by univariate and multivariate analysis identified G2890 (m/z value, 2890.052) as a significant recurrence factor and G3560 (m/z value, 3560.295) as a significant prognostic factor. G2890 and G3560 were found to be strongly correlated with tumor number, size, and vascular invasion. Conclusion: Quantitative glycoblotting based on whole serum N-glycan profiling is an effective approach to screening for new biomarkers. The G2890 and G3560 N-glycans determined by tumor glycomics appear to be promising biomarkers for malignant behavior in HCCs. (HEPATOLOGY 2013;57:2314-2325 H epatocellular carcinoma (HCC) is a common and fatal malignancy with a worldwide occurrence.1 Liver resection has shown the highest level of control among the local treatments for HCC and is associated with a good survival rate.2,3 However, the recurrence rates for HCC are still high even when a curative hepatectomy is performed. 4 Many factors associated with the prognosis and recurrence of HCC have now been reported. Vascular invasion of the portal vein and/or hepatic vein and tumor differentiation are important factors affecting survival and recurrence in HCC cases after a hepatectomy. 5,6 However, microvascular invasion and differentiation can only be detected by pathological examination just after a hepatectomy, and cannot be diagnosed preoperatively, and thus cannot be identified preoperatively either. Hence, the serum biomarkers alpha-fetoprotein (AFP) and protein induced by vitamin K absence-II (PIVKA-II) are used as prognostic markers 7,8 and also as surrogate markers for microvascular invasion and tumor differentiation.9,10 AFP is associated with grade differentiation, 11 whereas PIVKA-II is related to vascularAbbreviations: AFP, alpha-fetoprotein; AFP-L3, lens cul...

show abstract

Microvascular Invasion in Patients with Hepatocellular Carcinoma and Its Predictable Clinicopathological Factors

Abstract: The presence of MVI was the most important risk factor affecting recurrence and survival in HCC patients after curative resection. Furthermore, this study showed that gross classification of HCC can be very helpful in predicting the presence of MVI.

Cited by 345 publications

References 31 publications

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

Risk Factors for Early and Late Intrahepatic Recurrence in Patients with Single Hepatocellular Carcinoma Without Macrovascular Invasion after Curative Resection

Long-term Prognosis in Hepatocellular Carcinoma Patients after Hepatectomy

Identification of novel serum biomarkers of hepatocellular carcinoma using glycomic analysis

Contact Info

Product

Resources

About