Long-term Prognosis in Hepatocellular Carcinoma Patients after Hepatectomy

Zhou, Lei; Liu, Chang; Fang, Meng; Qu, Kai; Tian, Feng; Tai, Ming-Hui; Wei, Ji-Chao

doi:10.7314/apjcp.2012.13.2.483

Cited by 16 publications

(11 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Surgical resection, providing a long-term survival of HCC patients, is regarded as one of the standard treatments of HCC if the tumor is resectable (Personeni et al, 2012;Zhou et al, 2012b). However, approximately 30-50% patients develop HCC recurrence during the first year after surgery, and in general, the recurrent HCCs are more diffuse and hardly treatable Zhu et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

Fan

Shen²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Pyruvate kinase isozyme type M2 (PKM2) was first found in hepatocellular carcinoma (HCC), and its expression has been thought to correlate with prognosis. A large number of studies have demonstrated that epithelial-mesenchymal transition (EMT) is a crucial event in hepatocellular carcinoma (HCC) and associated metastasis, resulting in enhanced malignancy of HCC. However, the roles of PKM2 in HCC EMT and metastasis remain largely unknown. The present study aimed to determine the effects of PKM2 in EGF-induced HCC EMT and elucidate the molecular mechanisms in vitro. Our results showed that EGF promoted EMT in HCC cell lines as evidenced by altered morphology, expression of EMT-associated markers, and enhanced invasion capacity. Furthermore, the present study also revealed that nuclear translocation of PKM2, which is regulated by the ERK pathway, regulated β-catenin-TCF/LEF-1 transcriptional activity and associated EMT in HCC cell lines. These discoveries provide evidence of novel roles of PKM2 in the progression of HCC and potential therapeutic target for advanced cases.

show abstract

Section: Introductionmentioning

confidence: 99%

PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

Fan

Shen²,

Li³

et al. 2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Conversely, large and/or multinodular HCCs always presented a high recurrence rate, and these types of multinodular HCCs were much easier to identify as IM (Ikeda et al, 2003;Ariizumi et al, 2004). Cirrhosis was found to be the most important factor for hepatocarcinogenesis, particularly in patients with a viral hepatitis infection, and it is also believed to be an adverse risk factor (Zhou et al, 2012). As soon as the cancer appears, the cirrhotic liver enters a "highly carcinogenic state".…”

Section: Discussionmentioning

confidence: 99%

Clinicopathologic Characteristics and Prognoses for Multicentric Occurrence and Intrahepatic Metastasis in Synchronous Multinodular Hepatocellular Carcinoma Patients

Su²,

Peng³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

“…It is a highly vascular tumor characterized by fast infiltrating growth, early metastasis, high-grade malignancy (Lee et al, 2014) and poor therapeutic efficacy (Zhou et al, 2012).…”

Section: Resultsmentioning

confidence: 99%

Activity and Expression Pattern of NF-κB/P65 in Peripheral Blood from Hepatocellular Carcinoma Patients - Link to Hypoxia Inducible Factor -1α

Gaballah¹,

Zakaria²,

Ismail³

2014

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Background: Hepatocellular carcinoma is a complex and heterogeneous tumor with poor prognosis due to frequent intrahepatic spread and extrahepatic metastasis. The molecular mechanisms underlying HCC pathogenesis still remain obscure. Objectives: We aimed to investigate the abundance and the DNA binding activity of nuclear factor kappa B/p65 subunit in peripheral blood mononuclear cells from patients with HCC and to assess its prognostic significance and association with hypoxia inducible factor one alpha (HIF-1α) in blood. Subjects and methods: This study was carried out on 40 patients classified equally into liver cirrhosis (group I) and HCC (group II), in addition to 20 healthy volunteers (group III). All groups were subjected to measurement of NF-κB /P65 subunit expression levels by real time-PCR, and DNA binding activity was evaluated by transcription factor binding immunoassay. Serum HIF-1α levels were estimated by enzyme-linked immunosorbent assay (ELISA). Significant increase of both the expression level and DNA binding activity of NF-κB /P65 subunit together with serum HIF-1 alpha levels was noted in HCC patients compared to liver cirrhosis and control subjects, with significant positive correlation with parameters for bad prognosis of HCC. In conclusion, NF-κB signaling is activated in HCC and associated with disease prognosis and with high circulating levels of HIF-1 alpha.

show abstract

Long-term Prognosis in Hepatocellular Carcinoma Patients after Hepatectomy

Cited by 16 publications

References 12 publications

PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

PKM2 Regulates Hepatocellular Carcinoma Cell Epithelial-mesenchymal Transition and Migration upon EGFR Activation

Clinicopathologic Characteristics and Prognoses for Multicentric Occurrence and Intrahepatic Metastasis in Synchronous Multinodular Hepatocellular Carcinoma Patients

Activity and Expression Pattern of NF-κB/P65 in Peripheral Blood from Hepatocellular Carcinoma Patients - Link to Hypoxia Inducible Factor -1α

Contact Info

Product

Resources

About