MicroRNAs Looping Around Angiogenesis

Fiedler, Jan; Thum, Thomas

doi:10.1161/atvbaha.111.237602

Cited by 2 publications

(1 citation statement)

References 20 publications

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“…MicroRNAs (miRNAs) are short, non-coding RNAs that serve as translation inhibitors through promotion of messenger RNA (mRNA) degradation by imperfect base-pairing between the seed region in miRNA and the miRNA binding site in the 3′-untranslated region (3′ UTR) of target mRNAs. miRNAs can potentially target hundreds of distinct mRNAs and have been increasingly recognized as key regulators of gene expression involved in neuronal protection 6 – 8 . Surprisingly, miRNAs withstand repetitive freeze-thaw cycles, blood haemodialysis, and are even resistant to nuclease digestion 9 .…”

Section: Introductionmentioning

confidence: 99%

MicroRNA-194-5p Levels Decrease during Deep Hypothermic Circulatory Arrest

Wang

You

Zhao

et al. 2018

Sci Rep

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Hypothermia has been reported to be effective in protecting the brain in various clinical conditions, including resuscitation after cardiac arrest and complex cardiovascular surgery, and is considered to be a promising therapy for stroke. The present study aimed to confirm the pivotal role that miRNA-194-5p plays in deep hypothermia circulation arrest. On the basis of reductions in expression of miR-194-5p in the circulation of 21 aortic dissection patients who underwent deep hypothermia circulatory arrest, the specific expression, target, and function of miR-194-5p was investigated using primary neuron culture, polymerase chain reaction, in situ hybridization, and flow cytometry methods. Our results showed that miR-194-5p expression was significantly downregulated in hypothermia oxygen glucose deprivation-treated neurons in vitro. Cortical neurons transfected with miR-194-5p mimic exhibited increased death due to oxygen-glucose deprivation. MiR-194-5p mediated the regulation of neuronal death, which involves the downregulation of the specific target protein SUMO2, which is crucial to ischemia tolerance. Collectively, these data highlight the unique role of miR-194-5p in mediating the deep hypothermia circulation arrest response via the regulation of SUMO2. These findings suggest that miR-194-5p could be a potential therapeutic target for intervention in ischemic disease.

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Section: Introductionmentioning

confidence: 99%

MicroRNA-194-5p Levels Decrease during Deep Hypothermic Circulatory Arrest

Wang

You

Zhao

et al. 2018

Sci Rep

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Differential expression of miRNAs related to angiogenesis and adipogenesis in subcutaneous fat of obese and nonobese women

et al. 2018

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To disclose the mechanisms surrounding obesity, we selected microRNAs (miRNAs) that target genes involved in adipogenesis, angiogenesis, and inflammation and compared their expression levels in the subcutaneous adipose tissue of 40 obese and nonobese women. Mature miRNAs were extracted from subcutaneous adipose tissue samples that were collected during surgery and quantified by real-time polymerase chain reaction. miR-16 was overexpressed in the nonobese group (n-expression ratio = − 151.1; P < 0.001). Furthermore, the expression levels of two other miRNAs were significantly correlated with waist circumference in nonobese women (miR-27b, r = 0.453; P = 0.027 and miR-424-5p, r = 0.502, P = 0.014). Central and total subcutaneous adipose tissue thicknesses were correlated with miR-424-5p levels (r = 0.506, P = 0.034 and r = 0.475, P = 0.046, respectively) in the nonobese group. In the obese group, miR-424-5p expression was correlated with body mass index (r = 0.582, P = 0.018). miR-16 and miR-424 have shown correlations with body-fat-mass-related parameters. Because these miRNAs have vascular endothelial growth factor (VEGF) and its receptors as target genes, they may be involved in the alterations of angiogenesis observed in obesity. In addition, higher levels of miR-27 and miR-424 were correlated with higher fat depot measurements in nonobese women. These results highlight the importance of miRNA expression in subcutaneous adipose tissue and encourage further investigation of miRNAs as prognostic markers.

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MicroRNAs Looping Around Angiogenesis

Cited by 2 publications

References 20 publications

MicroRNA-194-5p Levels Decrease during Deep Hypothermic Circulatory Arrest

MicroRNA-194-5p Levels Decrease during Deep Hypothermic Circulatory Arrest

Differential expression of miRNAs related to angiogenesis and adipogenesis in subcutaneous fat of obese and nonobese women

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