2016
DOI: 10.1186/s41016-016-0049-0
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MicroRNAs as biomarkers in molecular diagnosis of refractory epilepsy

Abstract: MicroRNA (miRNA) is a type of endogenous non-coding RNA that can regulate cell proliferation, differentiation, invasion, apoptosis and several other biological activities by specially inducing gene silencing, and thereby is related to development and disease in life course. In recent years, researchers have found that miRNAs are closely related with refractory epilepsy. MiRNAs can intervene in the modification of mRNAs, the synthesis of proteins and some the connectivity of signal pathways in pathogenesis of e… Show more

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Cited by 7 publications
(2 citation statements)
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“…Additionally, Wang et al [107] revealed that changes in miRs expression are closely associated with the development of therapeutic resistance to AEDs, not only in patients with mTLE, but also in patients with other forms of epilepsy. For example, overexpression of miR-34a and miR-132 is associated with the death of brain neurons in the epileptogenic focus, which is caused by prolonged seizures, and pronounced miR-134 hypoexpression is associated with a low risk of epileptic seizures and status epilepticus.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, Wang et al [107] revealed that changes in miRs expression are closely associated with the development of therapeutic resistance to AEDs, not only in patients with mTLE, but also in patients with other forms of epilepsy. For example, overexpression of miR-34a and miR-132 is associated with the death of brain neurons in the epileptogenic focus, which is caused by prolonged seizures, and pronounced miR-134 hypoexpression is associated with a low risk of epileptic seizures and status epilepticus.…”
Section: Discussionmentioning
confidence: 99%
“…Serum profiles of the miRNA of 30 epileptic patients and 30 healthy control identified 4 miRNAs were significantly upregulated (let-7d-5p, miR-106b-5p, miR-130a-3p, and miR-146a-5p), whereas 6 miRNAs (miR-15a-5p, -144-5p, -181c-5p, -194-5p, -889-3p, and novel-mir-96) were downregulated. The authors further validated miR-144 and miR-96 were both downregulated with RT-PCR (Wang et al 2016) (Table 1).…”
Section: The Challenge Of Microrna In Epilepsymentioning
confidence: 96%