MicroRNA expression profiling during the suckling-to-weaning
                    transition in pigs

Jang, Hyun‐Jun; Lee, Sang In

doi:10.5187/jast.2021.e69

Cited by 7 publications

(4 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The miR-10b levels in villus upper cells on days 3 and 7 were significantly lower than that on day 14 post-weaning and strikingly reduced compared to day 0. These findings are consistent with the Jang and Lee [ 22 ] study, which performed microRNA expression profiling during the suckling-to-weaning transition in piglets to identify weaning-associated differentially expressed miRNAs. In that research, the authors found that miR-10a-5p, another member of the highly conserved miR-10 family, had a decreased expression at 1 week after weaning and a stable expression at 2 weeks after weaning.…”

Section: Discussionsupporting

confidence: 91%

Investigation of the Expression Pattern and Functional Role of miR-10b in Intestinal Inflammation

Song

et al. 2023

Animals

View full text Add to dashboard Cite

Implications of miRNAs for animal health management in livestock remain elusive. To identify suitable miRNAs as monitoring biomarkers, piglets were randomly selected for sampling on days 0, 1, 3, 7, and 14 post-weaning. The results show that miR-10b levels in the villus upper cells of the jejunum on days 3 and 7 were significantly lower than that on day 14 post-weaning and reduced by approximately 30% on day 3 and 55% on day 7 compared to day 0. In contrast, miR-10b in crypt cells decreased by approximately 82% on day 7 and 64% on day 14 compared with day 0. Next, miR-10 knockout mice and wild-type mice were subjected to dextran sulfate sodium (DSS) for 7 days. The findings demonstrate that mice lacking miR-10b were more susceptible to DSS administration, as demonstrated by worse survival, greater weight loss, more severe tissue damage, and increased intestinal permeability. Moreover, the increased disease severity was correlated with enhanced macrophage infiltration, coincident with significantly elevated pro-inflammatory mediators and immunoglobulins. Bioinformatic analysis further reveals that the enriched pathways were mainly involved in host immune responses, and Igtp was identified as a potential target of miR-10b. These findings may provide new strategies for future interventions for swine health and production.

show abstract

Section: Discussionsupporting

confidence: 91%

Investigation of the Expression Pattern and Functional Role of miR-10b in Intestinal Inflammation

Song

et al. 2023

Animals

View full text Add to dashboard Cite

show abstract

“…The intestinal epithelium digests and absorbs nutrients and forms a barrier against pathogens and toxic substances [1,2]. The intestinal epithelium is also important for maintaining health as it is the first physical barrier to detect external substances [3].…”

Section: Introductionmentioning

confidence: 99%

Lauric acid reduces apoptosis by inhibiting FOXO3a-signaling in Deoxynivalenol-treated IPEC-J2 cells

Kim,

Lee

2023

J Anim Sci Technol

View full text Add to dashboard Cite

show abstract

“…EVs consist of various types of biological products, including proteins, lipids, and microRNAs (miRNAs). miRNAs are small nucleic acids ranging from 18 to 22 nucleotides that play a role in regulating posttranscriptional gene regulation and transferring signals into the host ( 15 ). Previous studies have reported that miRNA has been associated with a variety of physiological functions, including the regulation of the immune system ( 16 ).…”

Section: Introductionmentioning

confidence: 99%

Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA let-7a-5p is mediated by regulating Akkermansia and β -hydroxybutyrate in gut environments

Mun,

Kang,

Shin

et al. 2023

Microbiol Spectr

View full text Add to dashboard Cite

Inflammatory bowel disease (IBD) is an inflammatory disease caused by the interaction of environmental and genetic factors, including diet and microbiota. Recent studies have suggested the effects of extracellular vesicles (EVs) on controlling host intestinal immune responses, although the specified mechanisms have not yet been fully elucidated. In the current study, we investigated the effects of EVs isolated from bovine colostrum on attenuating dextran sodium sulfate-induced colitis in mice. Multiomic approaches were used to assess host gene expression and gut microbiota profiles and to explain the roles of EVs in modulating the host immune system. Transcriptomic analyses suggested a possible immunoregulatory mechanism mediated by the cell cycle regulator CDK6 and pro-inflammatory responses. The gut microbiome composition and fecal metabolite profiles showed that EV supplementation promoted the microbial abundance of Akkermansia and short-chain fatty acid production in mice with colitis. Further in vivo analysis revealed that β-hydroxybutyrate and Akkermansia muciniphila , which are elevated by the administration with EVs, are involved in lessening colitis through modulating the immune system. Additionally, the bta-let-7a-5p, one of the most abundant microRNAs in bovine colostrum-derived EVs, alleviated the indications of colitis in mice by modulating their intestinal immunity and by regulating the cell cycle-related target gene Cdk6. Overall, these results suggest that bovine colostrum EVs and bta-let-7a-5p could be promising alternative strategies for preventing the onset of IBD. IMPORTANCE Even though studying on the possible involvement of extracellular vesicles (EVs) in host-microbe interactions, how these relationships mediate host physiology has not clarified yet. Our current findings provide insights into the encouraging benefits of dietary source-derived EVs and microRNAs (miRNAs) on organic acid production and ultimately stimulating gut microbiome for human health, suggesting that supplementation of dietary colostrum EVs and miRNAs is a novel preventive strategy for the treatment of inflammatory bowel disease.

show abstract

MicroRNA expression profiling during the suckling-to-weaning transition in pigs

Abstract: MicroRNA expression profiling during the suckling-toweaning transition in pigs

Cited by 7 publications

References 32 publications

Investigation of the Expression Pattern and Functional Role of miR-10b in Intestinal Inflammation

Investigation of the Expression Pattern and Functional Role of miR-10b in Intestinal Inflammation

Lauric acid reduces apoptosis by inhibiting FOXO3a-signaling in Deoxynivalenol-treated IPEC-J2 cells

Alleviation of DSS-induced colitis via bovine colostrum-derived extracellular vesicles with microRNA let-7a-5p is mediated by regulating Akkermansia and β -hydroxybutyrate in gut environments

Contact Info

Product

Resources

About