MicroRNA-675 promotes glioma cell proliferation and motility by negatively regulating retinoblastoma 1

Zheng, Yungui; Lu, Xiaowen; Xu, Liepeng; Chen, Zhe; Li, Qinxi; Yuan, Jun

doi:10.1016/j.humpath.2017.09.006

Cited by 21 publications

(11 citation statements)

References 32 publications

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“…RB1 was found to take part in dysregulation of human cancers, which was regulated by some miRNAs, including miR-26a and miR-335 [34,35]. Moreover, Zheng et al revealed that miR-675 promoted glioma cell proliferation and motility by negatively regulating RB1 [36]. In addition, miR-661 promoted tumor invasion and metastasis by activating EMT and directly inhibiting RB1 in non-small cell lung cancer [37].…”

Section: Discussionmentioning

confidence: 99%

MicroRNA-192 promotes the development of nasopharyngeal carcinoma through targeting RB1 and activating PI3K/AKT pathway

Huang

Hou²,

Zhu

et al. 2020

World J Surg Onc

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Background: The dysregulation of microRNAs (miRNAs) has been found in diseases and cancers, including microRNA-192 (miR-192). This study was designed to investigate the role of miR-192 in nasopharyngeal carcinoma (NPC) progression. Methods: The expression levels of miR-192 and some genes were assessed by qRT-PCR and Western blot. The function of miR-192 was investigated through MTT, Transwell, and dual-luciferase reporter assays. Results: The expression of miR-192 was increased in NPC tissues, and high miR-192 expression predicted poor prognosis in NPC patients. Functionally, upregulation of miR-192 promoted NPC cell migration, invasion, and growth. Furthermore, miR-192 activated EMT and PI3K/AKT pathway to regulate NPC progression. In addition, miR-192 directly targeted RB1 and suppressed its expression in NPC. Moreover, overexpression of RB1 weakened the promoted effect of miR-192 in NPC. Conclusion: miR-192 promoted cell viability and metastasis in NPC through suppressing RB1 expression and activating PI3K/AKT pathway.

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Section: Discussionmentioning

confidence: 99%

MicroRNA-192 promotes the development of nasopharyngeal carcinoma through targeting RB1 and activating PI3K/AKT pathway

Huang

Hou²,

Zhu

et al. 2020

World J Surg Onc

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“…miRs have been acknowledged as important players in tumorigenesis and can regulate tumor cell proliferation, survival and metastasis (17)(18)(19). A large number of studies indicate that miRs serve as oncogenes or tumor suppressors in almost all types of human cancer, including breast cancer (20), non-small cell lung cancer (21), prostate cancer (22), osteosarcoma (23), glioma (24) and GC (25). For example, Ding et al (26) reported that miR-367 regulates cell proliferation and metastasis by targeting metastasis-associated protein 3 in clear-cell renal cell carcinoma.…”

Section: Discussionmentioning

confidence: 99%

MicroRNA‑6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer

Zhang

et al. 2018

Exp Ther Med

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Accumulating evidence suggests that microRNAs (miRs) exert vital functions in the development and progression of multiple types of human cancer. However, the role of miR-6852 in gastric cancer (GC) remains unclear. In the present study, miR-6852 expression was significantly downregulated in GC tissues compared with adjacent normal tissues determined by reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis. Furthermore, miR-6852 expression levels in patients with GC were reversely correlated with tumor metastasis and TNM stage. Through Cell Counting kit-8 and Transwell assays, it was demonstrated that overexpression of miR-6852 significantly inhibited the proliferation, migration and invasion of GC cells. With regards to the mechanism involved, luciferase reporter assays suggested that miR-6852 directly target forkhead box J1 (FOXJ1) in GC cells. Furthermore, overexpression of miR-6852 markedly inhibited the mRNA and protein expression levels of FOXJ1 in GC cells determined by RT-qPCR and western blot analysis. Additionally, FOXJ1 was overexpressed in GC tissues and cell lines, and its expression was negatively correlated with that of miR-6852 in GC tissues. Rescue assays indicated that overexpression of FOXJ1 significantly reversed the effects of miR-6852 transfection on GC cell proliferation, migration and invasion. Taken together, the present findings demonstrated that miR-6852 exerted a tumor suppressive role through targeting FOXJ1 in GC. These results implied that miR-6852 may be a novel therapeutic target of GC treatment.

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“…Similarly, in plasma of lung metastatic patients, a significant upregulation of miR-675 was also observed compared to the nonmetastatic ones [56]. Interestingly, miR-675 is involved in migration, proliferation, and survival in multiple types of cancer [57,58]. Furthermore, this miRNA has been implicated in carcinogenesis and metastasis in gastric cancer by targeting Calneuron 1 (CALN1), a migration-related gene [59].…”

Section: Exosomal Mirnas In Pediatric Cancersmentioning

confidence: 99%

Exosomal MiRNAs in Pediatric Cancers

Galardi

Colletti

Paolo

et al. 2019

IJMS

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MicroRNAs (miRNAs) have generated great attention in oncology as they play a fundamental role in the regulation of gene expression and their aberrant expression is present in almost all types of tumors including pediatric ones. The discovery that miRNAs can be transported by exosomes, which are vesicles of 40-120 nm involved in cellular communication, that are produced by different cell types, and that are present in different biological fluids, has opened the possibility of using exosomal miRNAs as biomarkers. The possibility to diagnose and monitor the progression and response to drugs through molecules that can be easily isolated from biological fluids represents a particularly important aspect in the pediatric context where invasive techniques are often used. In recent years, the idea of liquid biopsy as well as studies on the possible role of exosomal miRNAs as biomarkers have developed greatly. In this review, we report an overview of all the evidences acquired in recent years on the identification of exosomal microRNAs with biomarker potential in pediatric cancers. We discuss the following herein: neuroblastoma, hepatoblastoma, sarcomas (osteosarcoma, Ewing's sarcoma and rhabdoid tumors, and non-rhabdomyosarcoma soft tissue sarcoma), brain tumors, lymphomas, and leukemias.

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MicroRNA-675 promotes glioma cell proliferation and motility by negatively regulating retinoblastoma 1

Cited by 21 publications

References 32 publications

MicroRNA-192 promotes the development of nasopharyngeal carcinoma through targeting RB1 and activating PI3K/AKT pathway

MicroRNA-192 promotes the development of nasopharyngeal carcinoma through targeting RB1 and activating PI3K/AKT pathway

MicroRNA‑6852 suppresses cell proliferation and invasion via targeting forkhead box J1 in gastric cancer

Exosomal MiRNAs in Pediatric Cancers

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