MicroRNA‐203 mediates Porphyromonas gingivalis LPS‐induced inflammation and differentiation of periodontal ligament cells

Abstract

Periodontitis, characterized by gingival inflammation and resorption of alveolar bone, is classically described as a bacterially induced chronic inflammatory disease of the periodontium (Darveau, 2010). The initial manifestation of periodontal disease chiefly includes gingivitis manifesting as gingival redness, swelling, and bleeding. With disease progression, periodontal attachment structures are destructed to varying degrees, manifesting as alveolar bone resorption and gingival recession (de Paiva Goncalves et al., 2018). As a specialized cellular connective tissue, the periodontal ligament (PDL) surrounds and anchors the teeth to the alveolar bone and periodontal ligament cells (PDLCs) retain capacity of promoting alveolar bone regeneration (Ivanovski et al., 2006).Porphyromonas gingivalis lipopolysaccharide (P. g. LPS) is believed to play a significant role in the pathogenesis of periodontitis (Liu et al., 2018;Yang et al., 2021) and has been widely applied to induce periodontitis for experimental purposes (Kim et al., 2019;

The Genetic Aspects of Periodontitis Pathogenesis and the Regenerative Properties of Stem Cells

“…MiR-203 targets activator protein-1, which is a transcription factor involved in the pathogenesis of PD. Therefore, the overexpression of miR-203 induces beneficial effects, such as the promotion of viability, inhibition of apoptosis and reduction in pro-inflammatory mediators [117].…”