Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation

Pacheco-Yanes, Juan; Reynolds, Eric; Li, Jian; Mariño, Eliana

doi:10.1016/j.molmed.2023.08.006

Cited by 8 publications

(3 citation statements)

References 111 publications

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“…The gut microbiome is widely believed to have a close relationship with human health, and is thought to have significant impacts on the autoimmune disease ( 7 , 8 ). Gut-associated IgAV symptoms, such as abdominal pain, are discussed to be dependent on changes in the composition and metabolic functions of the gut microbiota ( 9 ).…”

Section: Introductionmentioning

confidence: 99%

Taxonomic and functional shifts of gut microbiome in immunoglobulin A vasculitis children and their mothers

Liang,

Zhao,

Zhao

et al. 2024

Front. Pediatr.

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ObjectivesTo examine the gut microbiota characteristics in children with immunoglobulin A vasculitis and their interrelationships with the host, while evaluate the vertical inheritance of microbiota in the development and progression of IgA vasculitis.MethodsThis study investigated the gut microbiome of 127 IgA vasculitis mother-child pairs and 62 matched healthy mother-child pairs, and compared the gut microbial composition of different groups. The pathway enrichment analysis evaluated potential gut microbiome-mediated pathways involved in the pathophysiology of IgA vasculitis. The Spearman correlation analysis illustrated the relationships between clinical variables and bacterial biomarkers.ResultsThis study identified distinct intestinal microbiome in IgA vasculitis children compared to healthy children, and further pointed out the association in gut microbiota between IgA vasculitis children's and their mother's. The relative abundance of Megamonas and Lactobacillus in IgAV children was positively correlated with that in their mothers. The pathway enrichment analysis found microbial biosynthesis of vitamins and essential amino acids was upregulated in children with IgA vasculitis. Correlation analysis showed bacterial biomarkers were correlated with indicators of blood coagulation.ConclusionChildren with IgA vasculitis have unique bacterial biomarkers and may affect coagulation function, and their gut microbiome was closely associated with that of their mothers. The observed association in gut microbiota between IgA vasculitis children and their mothers suggested a potential intergenerational influence of the maternal microbiota on the development or progression of IgA vasculitis in children.

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Section: Introductionmentioning

confidence: 99%

Taxonomic and functional shifts of gut microbiome in immunoglobulin A vasculitis children and their mothers

Liang,

Zhao,

Zhao

et al. 2024

Front. Pediatr.

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“…Furthermore, the damage from dysbiosis is not only oral but non-oral enhancement of oral-to-gut, oral-to-brain, and oral-to-heart inflammatory axes may also occur. [17][18][19][20][21] Additionally, the subsequent depressed mucosal protective lining function and mucosal resistance enhances the risk for oral post-acute-sequelae conditions (PASC) or 'long haul' symptoms. These include PD, pulpitis, oral mucositis, xerostomia, sialadenitis, sialiolith, mucositis, vesicular diseases, dysgeusia, verrucous papilloma, various types of leukoplakias, and cancer.…”

Section: Introductionmentioning

confidence: 99%

“…This process may degrade oral mucosal tissue integrity and depress oral mucosal immune resistance to additional opportunistic infections such as Candida albicans and viruses, both dsDNA viruses and ssRNA viruses, noted by the clinical presentation of vesicular bullae and inflammatory diseases. Furthermore, the damage from dysbiosis is not only oral but non‐oral enhancement of oral‐to‐gut, oral‐to‐brain, and oral‐to‐heart inflammatory axes may also occur 17–21 . Additionally, the subsequent depressed mucosal protective lining function and mucosal resistance enhances the risk for oral post‐acute‐sequelae conditions (PASC) or ‘long haul’ symptoms.…”

Section: Introductionmentioning

confidence: 99%

SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19

Schwartz,

Capistrano,

Gluck

et al. 2024

Reviews in Medical Virology

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COVID‐19 as a pan‐epidemic is waning but there it is imperative to understand virus interaction with oral tissues and oral inflammatory diseases. We review periodontal disease (PD), a common inflammatory oral disease, as a driver of COVID‐19 and oral post‐acute‐sequelae conditions (PASC). Oral PASC identifies with PD, loss of teeth, dysgeusia, xerostomia, sialolitis‐sialolith, and mucositis. We contend that PD‐associated oral microbial dysbiosis involving higher burden of periodontopathic bacteria provide an optimal microenvironment for severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) infection. These pathogens interact with oral epithelial cells activate molecular or biochemical pathways that promote viral adherence, entry, and persistence in the oral cavity. A repertoire of diverse molecules identifies this relationship including lipids, carbohydrates and enzymes. The S protein of SARS‐CoV‐2 binds to the ACE2 receptor and is activated by protease activity of host furin or TRMPSS2 that cleave S protein subunits to promote viral entry. However, PD pathogens provide additional enzymatic assistance mimicking furin and augment SARS‐CoV‐2 adherence by inducing viral entry receptors ACE2/TRMPSS, which are poorly expressed on oral epithelial cells. We discuss the mechanisms involving periodontopathogens and host factors that facilitate SARS‐CoV‐2 infection and immune resistance resulting in incomplete clearance and risk for ‘long‐haul’ oral health issues characterising PASC. Finally, we suggest potential diagnostic markers and treatment avenues to mitigate oral PASC.

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Persistent luminescence encoding for rapid and accurate oral-derived bacteria identification

Zheng,

Xi,

Long

et al. 2024

Chinese Chemical Letters

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Microbiome-targeted interventions for the control of oral–gut dysbiosis and chronic systemic inflammation

Cited by 8 publications

References 111 publications

Taxonomic and functional shifts of gut microbiome in immunoglobulin A vasculitis children and their mothers

Taxonomic and functional shifts of gut microbiome in immunoglobulin A vasculitis children and their mothers

SARS‐CoV‐2, periodontal pathogens, and host factors: The trinity of oral post‐acute sequelae of COVID‐19

Persistent luminescence encoding for rapid and accurate oral-derived bacteria identification

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