2017
DOI: 10.3892/mmr.2017.6842
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MicroRNA-150 targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in papillary thyroid carcinoma

Abstract: Thyroid cancer is the most prevalent malignant tumor of the endocrine organs and accounts for one third of all head and neck tumors. Dysregulation of microRNAs is well‑known to contribute to the development of various cancers, including papillary thyroid carcinoma (PTC), which accounts for 80‑90% of all thyroid cancer cases. The present study aimed to investigate the expression, functional roles of microRNA‑150 (miR‑150) and its direct target gene in PTC. miR‑150 expression in PTC tissues and cell lines was an… Show more

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Cited by 22 publications
(15 citation statements)
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References 39 publications
(40 reference statements)
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“…Thyroid cancer (TC) is the most prevalent endocrine malignancy accounting for nearly one‐third of head and neck malignancy globally . The past decades have witnessed increased morbidity and mortality of thyroid cancer globally .…”
Section: Introductionmentioning
confidence: 99%
“…Thyroid cancer (TC) is the most prevalent endocrine malignancy accounting for nearly one‐third of head and neck malignancy globally . The past decades have witnessed increased morbidity and mortality of thyroid cancer globally .…”
Section: Introductionmentioning
confidence: 99%
“…miR-141-3p and miR-150 were separately demonstrated by different studies to be inversely associated with TNM stage and lymph node metastasis in PTC patients (53,58). Similarly, the inverse association between miR-199b-5p or miR-7 and TNM stage was shown in PTC patients (55,59).…”
Section: Ncrnas Playing Role As Prognostic Factors Of Thyroid Cancermentioning
confidence: 87%
“…A group of dysregulated miRNAs has been shown by in vitro and in vivo assays to inhibit apoptosis and promote proliferation, invasion and migration in thyroid cancer. For instance, the down-regulation of miR-524-5p (52), miR-141-3p (53), miR-9 (54), miR-199b-5p (55), miR-1266 (56), miR-144 (57), miR-150 (58) and miR-7 (59) were demonstrated to play pivotal roles in thyroid tumorigenesis. However, there is lack of inclusive data to know how these alterations could mechanistically impose tumorigenic properties in the context of thyroid cancer.…”
Section: Mirnas Regulating Thyroid Carcinogenesismentioning
confidence: 99%
“…Yin et al found that miR‐195 could inhibit the PTC cell lines BCPAP and K1 to proliferate and migrate by downregulating the expression of target genes CCND1 and FGF2. Cheng et al found that exogenous upregulation of miR‐150 could reduce cell proliferation and invasion, and proposed that its target gene was ROCK1. The downregulation of the miRNAs expression has been seen in most tumors, and overexpressed miRNAs can inhibit the proliferation and migration capabilities of tumor cells, which provides a new target for clinical treatment and diagnosis of PTC.…”
Section: Discussionmentioning
confidence: 99%