2019
DOI: 10.1111/jcmm.14386
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Long non‐coding RNA NR2F1‐AS1 promoted proliferation and migration yet suppressed apoptosis of thyroid cancer cells through regulating miRNA‐338‐3p/CCND1 axis

Abstract: Thyroid cancer (TC) is a prevalent endocrine malignant cancer whose pathogenic mechanism remains unclear. The aim of the study was to investigate the roles of long non‐coding RNA (lncRNA) NR2F1‐AS1/miRNA‐338‐3P/CCND1 axis in TC progression. Differentially expressed lncRNAs and mRNAs in TC tissues were screened out and visualized by R program. Relative expression of NR2F1‐AS1, miRNA‐338‐3p and cyclin D1 (CCND1) was determined by quantitative real time polymerase chain reaction. In addition, Western blot analysi… Show more

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Cited by 54 publications
(41 citation statements)
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References 32 publications
(36 reference statements)
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“…LncRNAs have been reported to be aberrantly expressed in many diseases, including cancer, and plays a vital role in tumor growth and progression . Furthermore, lncRNAs have been discovered to be participated in various biological and pathological activities, such as cell growth, apoptosis, invasion, and migration …”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…LncRNAs have been reported to be aberrantly expressed in many diseases, including cancer, and plays a vital role in tumor growth and progression . Furthermore, lncRNAs have been discovered to be participated in various biological and pathological activities, such as cell growth, apoptosis, invasion, and migration …”
Section: Introductionmentioning
confidence: 99%
“…[5][6][7][8] Furthermore, lncRNAs have been discovered to be participated in various biological and pathological activities, such as cell growth, apoptosis, invasion, and migration. [9][10][11] MicroRNAs (miRNAs) are another type of non-coding RNAs characterized by short length. It can interact with the 3′ untranslated regions (UTR) of the target genes via its microRNA response elements (MREs), which will silence the expression of downstream target genes.…”
Section: Introductionmentioning
confidence: 99%
“…NR2F1-AS1, a recently discovered lncRNA, has been found to enhance esophageal squamous cell carcinoma (ESCC) progression by regulating the Hedgehog signaling pathway (12). NR2F1-AS1 has also been reported to regulate the microRNA (miR)-338-3p/cyclin D1 axis to promote thyroid cancer progression (13). In papillary thyroid carcinoma, NR2F1-AS1 has been confirmed to exacerbate cell proliferation by regulating the miR-423-5p/SRY-box transcription factor (SOX)12 signaling pathway (14).…”
Section: Introductionmentioning
confidence: 99%
“…Recently, CCND1 has been identified as a key gene by integrated bioinformatics analysis [85]. Nevertheless, the role of CCND1 in thyroid tumorigenesis has been poorly investigated, except for recent papers showing CCND1 as a direct target of deregulated miRNAs and long non-coding RNAs [86][87][88]. We identified cyclin D1 as vulnerability for TC cells, as its siRNA-mediated inhibition causes consistent growth reduction of different thyroid tumor cell lines, but not normal ones.…”
Section: Validation Of Noa Targetsmentioning
confidence: 85%