2020
DOI: 10.1002/jcb.29604
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MiR‐145 inhibits the migration and invasion of papillary thyroid carcinoma cells through NF‐κB pathway regulation

Abstract: Papillary thyroid carcinoma (PTC) is the most prevalent cancer in the endocrine system, and the number of patients diagnosed with PTC has been increasing rapidly in recent years. Previous studies have reported that miR-145 plays an important role in many kinds of cancers, but its function in PTC remains unclear. In this study, we found that compared to paracancerous tissues, the level of miR-145 expression was significantly downregulated in PTC tissues.When miR-145 is overexpressed, migration and invasion of P… Show more

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Cited by 13 publications
(8 citation statements)
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“…In tumors, miRs can either function as tumor suppressor gene or oncogene by regulating downstream targets. It is reported that miR-145 was down-regulated in nasopharyngeal carcinoma [26], papillary thyroid carcinoma [27] and head and neck cancers [28]. For example, Liu et al [26] reported that miR-145 directed with CASC9, and the inhibition of miR-145 promoted cell migration and invasion but inhibited cell apoptosis in nasopharyngeal carcinoma cells, which provided a novel therapy for the treatment of nasopharyngeal carcinoma.…”
Section: Introductionmentioning
confidence: 99%
“…In tumors, miRs can either function as tumor suppressor gene or oncogene by regulating downstream targets. It is reported that miR-145 was down-regulated in nasopharyngeal carcinoma [26], papillary thyroid carcinoma [27] and head and neck cancers [28]. For example, Liu et al [26] reported that miR-145 directed with CASC9, and the inhibition of miR-145 promoted cell migration and invasion but inhibited cell apoptosis in nasopharyngeal carcinoma cells, which provided a novel therapy for the treatment of nasopharyngeal carcinoma.…”
Section: Introductionmentioning
confidence: 99%
“…Systematic search; duplicate removal; and screening of titles, abstracts, and full text yielded eight eligible articles [ 41 , 43 , 44 , 45 , 46 , 47 , 48 , 49 ]. The expression of miR-145 was significantly reduced in thyroid cancer compared with normal cells [ 41 ].…”
Section: Resultsmentioning
confidence: 99%
“…In literature, several papers reported that miR-145 is downregulated in thyroid cancer where it acts as a tumor suppressor by impairing cancer cell growth, cell motility, and metastasis through targeting AKT3 [ 59 ] and RAB5C [ 60 ] genes or by regulating the NF- κ B pathway [ 61 ].…”
Section: Discussionmentioning
confidence: 99%