2018
DOI: 10.1016/j.jneuroim.2018.06.010
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MicroRNA-150 targets PU.1 and regulates macrophage differentiation and function in experimental autoimmune encephalomyelitis

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Cited by 25 publications
(17 citation statements)
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“…In a study on Alzheimer's disease, downregulation of PU.1 in BV2 cells suppressed the expression of pro-inflammatory genes, such as CCL2 and IL-1β, as well as Aif1 (also known as Iba1), a molecular marker of microglia [37]. In another study with BMDM, miR-150-induced PU.1 downregulation inhibited the expression of pro-inflammatory cytokines and shifted the macrophage polarization toward the M2 state [42]. In a recent study of EAE mice, CNS microglia switched toward the M2 phenotype after BSYS (a traditional Chinese medicine) treatment.…”
Section: Discussionmentioning
confidence: 97%
“…In a study on Alzheimer's disease, downregulation of PU.1 in BV2 cells suppressed the expression of pro-inflammatory genes, such as CCL2 and IL-1β, as well as Aif1 (also known as Iba1), a molecular marker of microglia [37]. In another study with BMDM, miR-150-induced PU.1 downregulation inhibited the expression of pro-inflammatory cytokines and shifted the macrophage polarization toward the M2 state [42]. In a recent study of EAE mice, CNS microglia switched toward the M2 phenotype after BSYS (a traditional Chinese medicine) treatment.…”
Section: Discussionmentioning
confidence: 97%
“…miR-150 was identified as differentially regulated during the maturation of human monocytes into macrophages, where it was downregulated in macrophages compared to monocytes [41]. miR-150 expression was also decreased in LPS-stimulated murine BMDMs, which negatively correlated with PU.1 transcript expression, suggesting that miR-150 is inflammation responsive and may also interact with PU.1 [62]. Luciferase assays confirmed that miR-150 directly targeted the PU.1 transcript.…”
Section: Expression Analysis Identified De Mirnas Known To Be Involved In Macrophage Function or Differentiation In Other Species And/or mentioning
confidence: 91%
“…Luciferase assays confirmed that miR-150 directly targeted the PU.1 transcript. Furthermore, the overexpression of miR-150 in murine BMDMs significantly reduced PU.1 transcript expression and shifted polarization away from M1 [62].…”
Section: Expression Analysis Identified De Mirnas Known To Be Involved In Macrophage Function or Differentiation In Other Species And/or mentioning
confidence: 96%
“…Numerous studies including ours have reported a strong correlation between altered miRNA expression levels and secondary brain injury events (Liu et al 2014;Redell et al 2009; Wang et al 2015). Among these altered miRNAs, miR-146a, miR-223-3p, miR-155-5p, and miR-150 play key roles in in ammatory signaling (Cardoso et al 2012;Zhao et al 2011;Johnnidis et al 2008;Shakerian et al 2018). However, a mechanistic role for these in ammatory miRNAs in TBI-induced neuroin ammation is poorly understood.…”
Section: Introductionmentioning
confidence: 74%