MicroRNA-144: A novel biological marker and potential therapeutic target in human solid cancers

Abstract

MicroRNAs (miRNAs) are a class of small non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. It has been reported that microRNA-144 (miR-144) is highly conserved and can combine complementarily with the 3'-UTRs of target gene mRNAs to inhibit mRNA translation or promote targeted mRNA degradation. MiR-144 is abnormally expressed and has been identified as a tumor suppressor in many types of solid tumors. Increasing evidence supports a crucial role for miR-144 in modulating physiopathologic processes, such as proliferation, apoptosis, invasion, migration and angiogenesis in different tumor cells. Apart from these functions, miR-144 can also affect drug sensitivity, cancer treatment and patient prognosis. In this review, we summarize the biological functions of miR-144, its direct targets and the important signal pathways through which it acts in relation to various tumors. We also discuss the role of miR-144 in tumor biology and its clinical significance in detail and offer novel insights into molecular targeting therapy for human cancers.

Global microRNA expression profile in laryngeal carcinoma unveils new prognostic biomarkers and novel insights into field cancerization

“…We hypothesize that different numbers of DNA copies of the region coding miR-144-3p could be the reason for the small discrimination differences in its expression levels, and these small changes in RQ could strongly correlate as a marker for the expression of one or more linked genes in the same DNA region and thus explain its strong paradoxical association with survival. The controversial oncogene behavior of miR-144-3p has been previously reported in some other solid tumors, such as nasopharyngeal 23 and papillary thyroid carcinoma 24 , although in the majority of solid tumors, it is downregulated 25 . MiR-144-3p is a key regulator that has an effect on many downstream effector genes and thus participates in the regulation of key signaling pathways and tumor biology; however, differences between tissues could also be observed.…”

The Diagnosis Value of a Novel Model with 5 Circulating miRNAs for Liver Fibrosis in Patients with Chronic Hepatitis B

“…However, there are controversies about the origin of circulating miRNAs and lack of specificity to reflect the disease biology. miR-144 is such a marker which has been identified as a circulating biomarker for different cancers such as hepatocellular carcinoma, renal cell carcinoma, and oral squamous cell carcinoma [ 29 ], whereas 6 serum miRNAs (miR-21, miR-199a-5p, miR-200c, miR-31, let-7a, and let-7d) have been identified as biomarkers for idiopathic pulmonary fibrosis, which still needs further validation [ 30 , 31 ]. However, miRNAs for distinguishing different stages of liver fibrosis have not been well studied.…”

ABCA1 có thể đích tiềm năng của miRNA-144 trong tế bào sụn

“…Các nghiên cứu cho thấy miR-144 tham gia vào các quá trình sinh học của tế bào bao gồm tăng sinh, apoptosis, xâm nhập, di cư, chu kỳ tế bào và hình thành mạch (Le & Ho, 2019;Zhou, Wu, Li, & Zha, 2020). Trong một nghiên cứu kiểm tra vai trò của miR-144-3p trong sự phát triển thoái hóa khớp ở chuột đã nhận thấy sự tăng biểu hiện của miR-144-3p ở giai đoạn đầu của thoái hóa khớp (Zhang, Lygrisse, & Wang, 2017).…”